Rikenellaceae Explained

Rikenellaceae is a family of Gram-negative bacteria described by Noel R. Krieg in 2015. It contains nine genera, five of which are validly published by the International Code of Nomenclature of Prokaryotes.^[1] Bacteria with 16S ribosomal RNA highly similar to the Rikenella genus, as compared to the larger taxonomic order Bacteroidales, are classified in this family.^[2]

This family consists of non-motile, rod-shaped bacteria that are tolerant of bile. Most Rikenellaceae species have been identified in the gastrointestinal tract microbiomes of various animals.^[3]

Bacteria of this taxonomic family are elevated in the gut microbiomes of mice that are leptin-resistant obese and diabetic.^[4] However, Rikenellaceae bacteria are depleted in the gut microbiomes of obese American adults, leading to reduced synthesis of butyrate and disrupted metabolism.^[5]

Gut microbiomes with elevated levels of Rikenellaceae bacteria are associated with lupus and Alzheimer's disease in mice and colorectal cancer in humans.^{[6] [7] [8]}

Notes and References

1. Web site: Parte . Aidan C. . Carbasse . Joaquim Sardà . Meier-Kolthoff . Jan P. . Reimer . Lorenz C. . Göker . Markus . 23 July 2020 . Family Rikenellaceae . 8 April 2023 . List of Prokaryotic names with Standing in Nomenclature.
2. Krieg . Noel R. . 14 September 2015 . Rikenellaceae fam. nov. . . 1–2 . 10.1002/9781118960608.fbm00062. 9781118960608 .
3. Book: Graf, Joerg . The Prokaryotes . . 2014 . 978-3-642-38953-5 . Rosenberg . Eugene . 4th . 857–859 . The Family Rikenellaceae . 10.1007/978-3-642-38954-2_134 . DeLong . Edward F. . Lory . Stephen . Stackebrandt . Erko . Thompson . Fabiano.
4. Cani . Patrice D. . 24 April 2013 . Gut Microbiota and Obesity: Lessons from the Microbiome . . 12 . 4 . 381–387 . 10.1093/bfgp/elt014 . 23616309 . Oxford Academic. free .
5. Peters . Brandilyn A. . Shapiro . Jean A. . Church . Timothy R. . Miller . George . Trinh-Shevrin . Chau . Yuen . Elizabeth . Friedlander . Charles . Hayes . Richard B. . Ahn . Jiyoung . 2018-06-27 . A taxonomic signature of obesity in a large study of American adults . . en . 8 . 1 . 9749 . 10.1038/s41598-018-28126-1 . 29950689 . 6021409 . 2045-2322.
6. Wang . Hui . Wang . Gangduo . Banerjee . Nivedita . Liang . Yuejin . Du . Xiaotang . Boor . Paul J. . Hoffman . Kristi L. . Khan . M. Firoze . 12 April 2021 . Aberrant Gut Microbiome Contributes to Intestinal Oxidative Stress, Barrier Dysfunction, Inflammation and Systemic Autoimmune Responses in MRL/lpr Mice . . 12 . 651191 . 10.3389/fimmu.2021.651191 . 1664-3224 . 8071869 . 33912174 . free .
7. Bello-Medina . Paola C. . Corona-Cervantes . Karina . Zavala Torres . Norma Gabriela . González . Antonio . Pérez-Morales . Marcel . González-Franco . Diego A. . Gómez . Astrid . García-Mena . Jaime . Díaz-Cintra . Sofía . Pacheco-López . Gustavo . 26 July 2022 . Chronic-Antibiotics Induced Gut Microbiota Dysbiosis Rescues Memory Impairment and Reduces ß-Amyloid Aggregation in a Preclinical Alzheimer's Disease Model . . en . 23 . 15 . 8209 . 10.3390/ijms23158209 . 35897785 . 9331718 . 1422-0067 . free .
8. Hoang . Tung . Kim . Min Jung . Park . Ji Won . Jeong . Seung-Yong . Lee . Jeeyoo . Shin . Aesun . 14 June 2022 . Nutrition-Wide Association Study of Microbiome Diversity and Composition in Colorectal Cancer Patients . . 22 . 1 . 656 . 10.1186/s12885-022-09735-6 . 1471-2407 . 9199192 . 35701733 . free .