Rifampicin/isoniazid/pyrazinamide explained

Rifampicin/isoniazid/pyrazinamide, also known as rifampin/isoniazid/pyrazinamide, and sold under the trade name Rifater, is a medication used to treat tuberculosis. It is a fixed dose combination of rifampicin, isoniazid, and pyrazinamide. It is used either by itself or along with other antituberculosis medication. It is taken by mouth.[1]

Side effects are those of the underlying medications.[1] These may include poor coordination, loss of appetite, nausea, joint pain, feeling tired, and numbness.[2] Severe side effects include liver problems. Use in those under the age of 15 may not be appropriate. It is unclear if use in pregnancy is safe for the baby.[3]

Rifampicin/isoniazid/pyrazinamide was approved for medical use in the United States in 1994.[3] It is on the World Health Organization's List of Essential Medicines.[4]

Medical uses

The hope of a fixed-dose combination pill is to increase the likelihood that people will take all of three medications.[5] Also, if people forget to take one or two of their drugs, they might not then develop resistance to the remaining drugs.

Society and culture

It is manufactured by Aventis.

See also

Notes and References

  1. Book: WHO Model Formulary 2008 . 2009 . 9789241547659 . ((World Health Organization)) . Stuart MC, Kouimtzi M, Hill SR . 10665/44053 . World Health Organization . World Health Organization . free . 143 .
  2. Web site: Rifater Side Effects in Detail - Drugs.com. www.drugs.com. 18 December 2016. live. https://web.archive.org/web/20161221013131/https://www.drugs.com/sfx/rifater-side-effects.html. 21 December 2016.
  3. Web site: Rifater - FDA prescribing information, side effects and uses. www.drugs.com. 18 December 2016. October 2016. live. https://web.archive.org/web/20161221013153/https://www.drugs.com/pro/rifater.html#dosage_administration. 21 December 2016.
  4. Book: ((World Health Organization)) . World Health Organization model list of essential medicines: 21st list 2019 . 2019 . 10665/325771 . World Health Organization . World Health Organization . Geneva . WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO . free .
  5. Book: Brown MJ, Sharma P, Bennett PN . Clinical Pharmacology. 2012-07-30. Elsevier Health Sciences. 978-0-7020-5113-5. 204. en.

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