Richard I. Morimoto Explained
Richard I. Morimoto is a Japanese American molecular biologist. He is the Bill and Gayle Cook Professor of Biology and Director of the Rice Institute for Biomedical Research at Northwestern University.[1]
Education and academic career
He holds a B.S. from the University of Illinois at Chicago, received a Ph.D. in biology (laboratory of Professor Murray Rabinowitz) from The University of Chicago in 1978, and conducted postdoctoral research (laboratory of Professor Matthew Meselson)[2] and was a Tutor in Biochemical Sciences at Harvard University in Cambridge, MA. In 1982, Morimoto joined the faculty of the Department of Biochemistry, Molecular Biology, and Cell Biology at Northwestern University in Evanston, IL. He served previously as the Chair of Biochemistry, Molecular Biology, and Cell Biology, the Dean of The Graduate School, and the Associate Provost of Graduate Education at Northwestern University.
Civic leadership
- Faculty liaison to founding of the Asian American Studies Program at title=Asian American Studies Program - Northwestern University |url=https://asianamerican.northwestern.edu/ |access-date=2022-04-20 |website=asianamerican.northwestern.edu |language=en}} – March, 1995
- Faculty Advisory Board – Asian American Studies Program at Northwestern University – 1999-
- Midwest Buddhist Temple, Chicago, IL. – Board of Trustees, 2004-; President, Board of Trustees, 2009 – 2014
- Japanese American Citizens League, Japanese American of the Biennium, 2010
- Chicago Nikkei Forum, 2014-
- Board of Trustees, Japanese American National Museum, 2014-
- Japanese American Leadership Delegation, 2015, U.S.-Japan Council (USJC), Foreign Ministry of Japan
Science
Morimoto is widely recognized for his research on the regulation of the heat shock stress response and the function of molecular chaperones.[3] His current research is to understand how organisms sense and respond to physiologic and environmental stress through the activation of genetic pathways that integrate stress responses with molecular and cellular responses that determine cell growth and cell death. The stress of misfolded and damaged proteins influences neuronal function and lifespan at the level of the organism. Consequently, these studies provide a molecular basis to elucidate the underlying mechanisms of neurodegenerative diseases including Huntington's disease, Parkinson's disease, ALS, and Alzheimer's disease. His laboratory has published over 250 papers and three monographs including two books on the Heat Shock Response and Molecular Chaperones from Cold Spring Harbor Press. During that period he received two MERIT awards from the National Institutes of Health and has been supported by the grants from the National Institutes for General Medical Science, National Institutes of Aging, National Institutes for Neurological Diseases and Stroke, American Cancer Society, Huntington's Disease Society of America, the Hereditary Disease Foundation, and the ALS Association. In addition to giving frequent talks at universities and scientific symposia throughout the world, he has been a visiting professor at the Technion University in Israel, Osaka University, Kyoto University, Kyoto Sangyo University, University of Rome, Beijing University, Åbo Akademi University in Finland, and École Normale Supérieure in Paris. He is a founder of Proteostasis Therapeutics, Inc. in Cambridge, MA, a biotech company that is discovering and developing novel small molecule therapeutics designed to control the body's protein homeostasis. These novel therapies are designed to treat multiple degenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease, cancer, and type II diabetes.
Science recognition
- American Cancer Society Faculty Research Award, 1987
- Commandeur, Ordre des Palmes Académiques, Ministry of Education, France, 2013[4]
- Doctor of Philosophy, Honoris Causa – Abo Akademi University, Turku, Finland, 2008
- Dreyfus Distinguished Young Faculty Award, 1982
- Elected Fellow of the American Academy of Arts and Sciences, 2011
- Elected Fellow of the American Association for the Advancement of Science, 1998
- Feodor Lynen Medal, 2014
- National Institutes of Health Merit Award - National Institute for General Medical Science (2000), National Institute on Aging (2011)
- Huntington's Disease Society of America, Award for Excellence in Medicine, 2005
- Japan Society for the Promotion of Science Fellow, 2015
- University of Illinois, Alumni Achievement Award, 2011
Significant papers
- Capano, L. S., C. Sato, E. Ficulle, A. Yu, K. Horie, N. R. Barthelemy, S. G. Fox, C. M. Karch, R. J. Bateman, H. Houlden, R. I. Morimoto, D. M. Holtzman, K. E. Duff, and A. S. Yoo. Recapitulation of Endogenous 4R Tau Expression Analogous to the Adult Brain in Directly Reprogrammed Human Neurons. Cell Stem Cell. 29: 918–932, doi: 10.1016/j.stem.2022.04.018 (2022).
- Morimoto, R.I., and G.S. Budinger. Protein Folding Disorders. In: Harrison's Principles of Internal Medicine (eds. J. Loscalzo, A. Fauci, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson), 21, Ch. 491 (2022).
- Sala, A.J. and R.I. Morimoto. Protecting the Future: Balancing Proteostasis for Reproduction. Trends in Cell Biology. 32(3): 202–215, doi.org/10.1016/j.tcb.2021.09.009 (2022).
- Sinnige, T., G. Meisl, T. C. T. Michaels, M. Vendruscolo, T. P.J. Knowles, and R. I. Morimoto. Kinetic Analysis Reveals that Independent Nucleation Events Determines the Progression of Protein Aggregation in C. elegans. Proc. Natl. Acad. Sci. U.S.A. 118(11): https://doi.org/10.1073/pnas.2021888118 (2021).
- Sala, A.J., L.C. Bott, R.M. Brielmann, and R.I. Morimoto. Embryo Integrity Regulates Maternal Proteostasis and Stress Resilience. Genes and Development. 34: 678–687, doi:10.1101/gad.335422.119, PMID 32217667 (2020).
- Morimoto, R.I. Cell Non-Autonomous Regulation of Proteostasis in Aging and Disease. Cold Spring Harbor Perspectives in Biology DOI: 10.1101/cshperspect.a034074 (2019).
- Morimoto, R.I. Cell Non-Autonomous Regulation of Proteostasis in Aging and Disease. Protein Homeostasis in Biology and Disease, eds. R.I. Morimoto, F. U. Hartl and J. W. Kelly, Cold Spring Harbor Press, 552p. (2019).
- Yu, A., S.G. Fox, A. Cavallini, C. Kerridge, M. J. O'Neill, J. Wolak, S. Bose, and R. I. Morimoto. Tau Protein Aggregates Inhibit the Protein-Folding and Vesicular Trafficking Arms of the Cellular Proteostasis Network. J. Biological Chemistry 294(19): 7917-7930 DOI:10.1074/jbc.RA119.007527 (2019).
- Stoeger, T., M. Gerlach, R.I. Morimoto, and L.N. Amaral. Large Scale Investigation of the Reasons why Potentially Important Genes are Ignored. PLoS Biology 16(9): e2006643 DOI.org/10/1371/journal.pbio.2006643 (2018).
- Ciryam, P., I. Lambert-Smith, D. M. Bean, D. N. Saunders, M. R. Wilson, R. I. Morimoto, S. G. Oliver, C. M. Dobson, M. Vendruscolo, G. Favrin, and J. J. Yerbury. Tissue-specific Patterns of Supersaturation are Associated with Co-Aggregation in ALS Inclusion Bodies. Proc. Natl. Acad. Sci. USA. 114(20): E3935–E3943 DOI:10.1073/pnas.1613854114 (2017).
- Sala, A.J., L.C. Bott, and R.I. Morimoto. Shaping Proteostasis at the Cellular, Tissue, and Organismal Level. Journal of Cell Biology 216: DOI: 10.1083/jcb.201612111 (2017).
- Kundra, R., P. Ciryam, R. I. Morimoto, C. M. Dobson, and M. Vendruscolo. Protein Homeostasis of a Metastable Subproteome Associated with Alzheimer's Disease. Proc. Natl. Acad. Sci. USA. 114(28): E5703-E5711 DOI: 10.1073/pnas.1618417114 (2017).
- Li, J., J. Labbadia, and R.I. Morimoto. Rethinking the Roles of HSF-1 in Cell Stress, Development and Organismal Health. Trends in Cell Biology 12: DOI: org/10.1016/ j.tcb.2017.08.002 (2017).
- Kirstein, J., K. Arnsburg, A. Scior, A. Szlachcic, D. Lys Guilbride, R.I. Morimoto, B. Bukau, and N.B. Nillegoda. In vivo Properties of the Disaggregase Function of J-domain Proteins and Hsc70 in C. elegans Stress and Aging. Aging Cell 16: 1414–1424, DOI: 10.1111/acel.12686 (2017).
- Labbadia, J., R. Brielmann, M. Neto, Y.-F. Lin, C.M. Haynes, and R.I. Morimoto. Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse During Aging. Cell Reports 21: 1481–1494, DOI.org/10.1016/ j.celrep.2017.10.038 (2017).
- Ciryam, P., R. Kundra, R. Freer, R. I. Morimoto, C. M. Dobson, and M. Vendruscolo. A Transcriptional Signature of Alzheimer's Disease is Associated with a Metastable Subproteome at Risk for Aggregation. Proc. Natl. Acad. Sci. U.S.A. 113 (17): 4753-4758 DOI: 10.1073 (2016).
- Li, J., L. Chauve, G. Phelps, R. Brielmann, and R.I. Morimoto. E2F Co-regulates an Essential HSF Developmental Program Distinct from the Heat Shock Response. Genes and Development 30: 2062-2075 PMID 27688402 (2016).
- Winter, P. B., R. M. Brielmann, N. P. Timkovich, H. T. Navarro, A. Teixeira-Castro, R. I. Morimoto, and L. A. N. Amaral. A Network Approach to Discerning the Identities of Visually Indistinguishable Organisms in a Free Moving Population. Scientific Reports 6: DOI: 10.1038/srep34859 (2016).
- 26373603 . 10.1093/brain/awv262 . 138 . Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease . 2015 . Brain . 3221–37 . Teixeira-Castro . A . Jalles . A . Esteves . S . Kang . S . da Silva Santos . L . Silva-Fernandes . A . Neto . MF . Brielmann . RM . Bessa . C . Duarte-Silva . S . Miranda . A . Oliveira . S . Neves-Carvalho . A . Bessa . J . Summavielle . T . Silverman . RB . Oliveira . P . Morimoto . RI . Maciel . P. 11 . 4731417 . free .
- 26245380 . 10.1038/nature14884 . 524 . Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation . 4830470 . 2015 . Nature . 247–51 . Nillegoda . NB . Kirstein . J . Szlachcic . A . Berynskyy . M . Stank . A . Stengel . F . Arnsburg . K . Gao . X . Scior . A . Aebersold . R . Guilbride . DL . Wade . RC . Morimoto . RI . Mayer . MP . Bukau . B. 7564 . 2015Natur.524..247N .
- 26228940 . 10.15252/embj.201591711 . 34 . Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments . 4570520 . 2015 . EMBO J . 2334–49 . Kirstein . J . Morito . D . Kakihana . T . Sugihara . M . Minnen . A . Hipp . MS . Nussbaum-Krammer . C . Kasturi . P . Hartl . FU . Nagata . K . Morimoto . RI. 18 .
- Labbadia . J. . Morimoto . R.I. . 2015. Repression of the Heat Shock Response is a Programmed Event at the Onset of Reproduction . Molecular Cell . 59 . 4 . 639–650 . 10.1016/j.molcel.2015.06.027 . 26212459 . 4546525 . free .
- 25957690 . 10.1016/j.cell.2015.03.032 . 161 . Widespread Proteome Remodeling and Aggregation in Aging C. elegans . 4643853 . 2015 . Cell . 919–32 . Walther . DM . Kasturi . P . Zheng . M . Pinkert . S . Vecchi . G . Ciryam . P . Morimoto . RI . Dobson . CM . Vendruscolo . M . Mann . M . Hartl . FU. 4 .
- 25784053 . 10.1146/annurev-biochem-060614-033955 . 84 . The biology of proteostasis in aging and disease . 4539002 . 2015 . Annu Rev Biochem . 435–64 . Labbadia . J . Morimoto . RI.
- 25626813 . 10.1097/PRS.0000000000001114 . 135 . Combined use of crushed cartilage and fibrin sealant for radix augmentation in Asian rhinoplasty . 2015 . Plast Reconstr Surg . 293e–300e . Yu . MS . Kim . BH . Kang . SH . Lim . DJ. 2 . 40582922 .
- 25557666 . 10.1016/j.cub.2014.11.040 . 25 . Neuronal serotonin release triggers the heat shock response in C. elegans in the absence of temperature increase . 4840938 . 2015 . Curr Biol . 163–74 . Tatum . MC . Ooi . FK . Chikka . MR . Chauve . L . Martinez-Velazquez . LA . Steinbusch . HW . Morimoto . RI . Prahlad . V. 2 .
- 25406061 . 10.1371/journal.pbio.1001998 . 12 . Modulation of the maladaptive stress response to manage diseases of protein folding . 4236052 . 2014 . PLOS Biol. . e1001998 . Roth . DM . Hutt . DM . Tong . J . Bouchecareilh . M . Wang . N . Seeley . T . Dekkers . JF . Beekman . JM . Garza . D . Drew . L . Masliah . E . Morimoto . RI . Balch . WE. 11 . free .
- 25417146 . 10.1016/j.cell.2014.10.039 . 159 . Geroscience: linking aging to chronic disease . 4852871 . 2014 . Cell . 709–13 . Kennedy . BK . Berger . SL . Brunet . A . Campisi . J . Cuervo . AM . Epel . ES . Franceschi . C . Lithgow . GJ . Morimoto . RI . Pessin . JE . Rando . TA . Richardson . A . Schadt . EE . Wyss-Coray . T . Sierra . F. 4 .
- 25437566 . 10.1016/j.celrep.2014.09.042 . 9 . A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease . 4255334 . 2014 . Cell Rep . 1135–50 . Brehme . M . Voisine . C . Rolland . T . Wachi . S . Soper . JH . Zhu . Y . Orton . K . Villella . A . Garza . D . Vidal . M . Ge . H . Morimoto . RI. 3 .
- 25030693 . 10.1101/gad.241125.114 . 28 . Organismal proteostasis: role of cell-nonautonomous regulation and transcellular chaperone signaling . 4102760 . 2014 . Genes Dev . 1533–43 . van Oosten-Hawle . P . Morimoto . RI. 14 .
- 24845679 . 10.1016/j.cub.2014.03.033 . 24 . How the nucleus copes with proteotoxic stress . 4207067 . 2014 . Curr Biol . R463-74 . Shibata . Y . Morimoto . RI. 10 .
- 24706768 . 10.1073/pnas.1321811111 . 111 . Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition . 3992642 . 2014 . Proc Natl Acad Sci U S A . E1481-90 . Yu . A . Shibata . Y . Shah . B . Calamini . B . Lo . DC . Morimoto . RI. 15 . 2014PNAS..111E1481Y . free .
- Ciryam . P. . Tartaglia . G. G. . Morimoto . R. I. . Dobson . C. M. . Vendruscolo . M. . 2013. Neurodegenerative Diseases and Widespread Aggregation are Associated with Supersaturated Proteins . Cell Reports . 5 . 3 . 781–790 . 10.1016/j.celrep.2013.09.043 . 24183671 . 3883113 . free .
- Gidalevitz . G. . Wang . N. . Deravaj . T. . Morimoto . R.I. . 2013 . Natural Genetic Variation Determines Susceptibility to Aggregation or Toxicity in a C. elegans model for Polyglutamine Disease . BMC Biology . 11 . 100 . 10.1186/1741-7007-11-100 . 24079614 . 3816611 . free .
- Silva . M. C. . Amaral . M. D. . Morimoto . R.I. . Neuronal Reprogramming of Protein Homeostasis by Calcium-Dependent Regulation of the Heat Shock Response . PLOS Genetics . 2013 . 9 . 8. e1003711 . 10.1371/journal.pgen.1003711 . 24009518 . 3757039 . free .
- Labbadia . J. . Morimoto . R.I. . 2013 . Huntington's Disease – Underlying Molecular Mechanisms and Emerging Concepts . Trends in Biochemical Sciences . 38 . 8. 378–385 . 10.1016/j.tibs.2013.05.003 . 23768628 . 3955166 .
- van Oosten-Hawle . P. . Porter . R. . Morimoto . R. I. . 2013 . Regulation of Organismal Proteostasis by Transcellular Chaperone Signaling . Cell . 153 . 6 . 1366–1378 . 10.1016/j.cell.2013.05.015 . 23746847 . 3955170 .
- 23604074 . 10.1038/emboj.2013.87 . 32 . The nascent polypeptide-associated complex is a key regulator of proteostasis . 3655472 . 2013 . EMBO J . 1451–68 . Kirstein-Miles . J . Scior . A . Deuerling . E . Morimoto . RI. 10 .
- Guisbert . E. . Czyz . D. M. . Richter . K. . McMullen . P. D. . Morimoto . R. I. . Identification of a Tissue-Selective Heat Shock Response Regulatory Network . PLOS Genetics . 2013 . 9 . 4. e1003466 . 10.1371/journal.pgen.1003466 . 23637632 . 3630107 . free .
- Krammer . C. . Park . K.W. . Li . L. . Melki . R. . Morimoto . R.I. . Spreading of a Prion Domain from Cell to Cell by Vesicular Transport in C. elegans . PLOS Genetics . 2013 . 9 . 3. e1003351 . 10.1371/journal.pgen.1003351 . 23555277 . 3610634 . free .
- 23256155 . 10.1073/pnas.1213624110 . 110 . In vivo translation rates can substantially delay the cotranslational folding of the Escherichia coli cytosolic proteome . 3545769 . 2013 . Proc Natl Acad Sci U S A . E132-40 . Ciryam . P . Morimoto . RI . Vendruscolo . M . Dobson . CM . O'Brien . EP. 2 . free .
- 22990239 . 10.1038/emboj.2012.264 . 31 . Metazoan Hsp70 machines use Hsp110 to power protein disaggregation . 3492728 . 2012 . EMBO J . 4221–35 . Rampelt . H . Kirstein-Miles . J . Nillegoda . NB . Chi . K . Scholz . SR . Morimoto . RI . Bukau . B. 21 .
- 22371371 . 10.1101/sqb.2012.76.010637 . 76 . The heat shock response: systems biology of proteotoxic stress in aging and disease . 2011 . Cold Spring Harb Symp Quant Biol . 91–9 . Morimoto . RI. free .
- Silva . M. C. . Fox . S. . Thakkar . H. . Beam . M. J. Rivera . Amaral . M. D. . Morimoto . R.I. . A Genetic Screening Strategy Identifies Novel Global Regulators of the Proteostasis Network . PLOS Genetics . 2011 . 7 . 12. e1002438 . 10.1371/journal.pgen.1002438 . 22242008 . 3248563 . free .
- Calamini . B. . Silva . C. . Madoux . F. . Hutt . D. M. . Khanna . S. . Chalfant . M. . Hodder . P. . Tait . B. . Garza . D. . Balch . W. . Morimoto . R.I. . 2012. Small Molecule Proteostasis Regulators for Protein Conformational Disease . Nature Chemical Biology . 8. 2 . 185–196. 10.1038/nchembio.763 . 22198733 . 3262058 .
- 21546381 . 10.1093/hmg/ddr203 . 20 . Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans: rescue by the DAF-16 and HSF-1 pathways . 3131043 . August 2011 . Hum. Mol. Genet. . 2996–3009 . Teixeira-Castro . A . Ailion . M . Jalles . A . 15 . etal.
- 21844355 . 10.1073/pnas.1106557108 . 108 . Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins . 3161566 . 2011 . Proc Natl Acad Sci U S A . 14204–9 . Prahlad . V . Morimoto . RI. 34 . 2011PNAS..10814204P . free .
- 21536706 . 10.1101/cshperspect.a009704 . 3 . The stress of protein misfolding: from single cells to multicellular organisms . June 2011 . Cold Spring Harb Perspect Biol . Gidalevitz . T . Prahlad . V . Morimoto . RI . 6 . a009704. 3098679 . free .
- Åkerfelt . M. . Morimoto . R.I. . Sistonen . L. . 2010. Heat Shock Factors: Integrators of Cell Stress, Development, and Lifespan . Nature Reviews Molecular Cell Biology . 11 . 8 . 545–555 . 10.1038/nrm2938 . 20628411 . 3402356 .
- Ben-Zvi-A . Miller . E.A. . Morimoto . R.I. . 2009. The Collapse of Proteostasis Represents an Early Molecular Event in C. elegans Aging . Proc. Natl. Acad. Sci. USA . 106 . 35 . 14914–14919 . 10.1073/pnas.0902882106 . 19706382 . 2736453 . free .
- Powers . E.T. . Morimoto . R.I. . Dillin . A. . Kelly . J.W. . Balch . W.E. . 2009 . Biological and Chemical Approaches to Diseases of Proteostasis Deficiency . Annual Review of Biochemistry . 78 . 959–991 . 10.1146/annurev.biochem.052308.114844 . 19298183 .
- Westerheide . S.D. . Anckar . J. . Stevens . S. . Sistonen . L. . Morimoto . R.I. . 2009 . Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1 . Science . 323 . 5917 . 1063–1066 . 10.1126/science.1165946 . 19229036 . 3429349 . 2009Sci...323.1063W .
- Prahlad . V. . Cornelius . T. . Morimoto . R.I. . 2008 . Regulation of the Cellular Heat Shock Response in Caenorhabditis elegans by Thermosensory Neurons . Science . 320 . 5877 . 811–814 . 10.1126/science.1156093 . 18467592 . 3429343 . 2008Sci...320..811P .
- Balch . W. E. . Morimoto . R.I. . Dillin . A. . Kelly . J. W. . 2008 . Adapting Proteostasis for Disease Intervention . Science . 319 . 5865 . 916–919 . 10.1126/science.1141448 . 18276881 . 2008Sci...319..916B . 20952037 .
- Morimoto . R.I. . 2008. Proteotoxic Stress and Inducible Chaperone Networks in Neurodegenerative Disease and Aging . Genes & Development . 22 . 11 . 1427–1438 . 10.1101/gad.1657108 . 18519635 . 2732416 . free .
- Garcia . S. . Casanueva . M.O. . Silva . C. . Amaral . M. . Morimoto . R.I. . 2007. Neuronal Signaling Modulates Protein Homeostasis in Caenorhabditis elegans Postsynaptic Muscle Cells . Genes & Development . 21 . 22 . 3006–3016 . 10.1101/gad.1575307 . 18006691 . 2049200 . free .
- Brignull . H. . Moore . F. . Tang . S. . Morimoto . R.I. . 2006 . Polyglutamine Proteins at the Pathogenic Threshold Display Neuron-Specific Aggregation in a Pan-Neuronal C. elegans Model . Journal of Neuroscience . 26 . 29 . 7597–7606 . 10.1523/jneurosci.0990-06.2006 . 16855087 . 6674286 . free .
- Gidalevitz . T. . Ben-Zvi . A. . Ho . K. . Brignull . H. . Morimoto . R.I. . 2006 . Progressive Disruption of Cellular Protein Folding in Models of Polyglutamine Diseases . . Science . 311 . 5766 . 1471–1474 . 10.1126/science.1124514 . 16469881 . 2006Sci...311.1471G . 8210087 . free .
- Holmberg . C. . Staniszewski . K. . Mensah . K. . Chavez . A. . Matouschek . A. . Morimoto . R.I. . 2004. Inefficient Degradation of Truncated Polyglutamine Proteins by the Proteasome . EMBO Journal . 23 . 21 . 4307–4318 . 10.1038/sj.emboj.7600426 . 15470501 . 524390 .
- Morley . J.F. . Morimoto . R.I. . 2004 . Regulation of Longevity in C. elegans by Heat Shock Factor and Molecular Chaperones . Mol. Biol. Cell . 15 . 2 . 657–664 . 10.1091/mbc.e03-07-0532 . 14668486 . 329286 .
- Morimoto . R.I. . 2002 . Dynamic Remodeling of Transcription Complexes by Molecular Chaperones . Cell . 110 . 3 . 281–284 . 10.1016/s0092-8674(02)00860-7 . 12176314 . 9013678 . free .
- Kim . S. . Nollen . E.A.A. . Kitagawa . K. . Bindokas . V. . Morimoto . R.I. . 2002 . Polyglutamine Protein Aggregates are Dynamic . Nature Cell Biology . 4 . 10 . 826–831 . 10.1038/ncb863 . 12360295 . 16305135 .
- Morley J.F., Brignull H.R., Weyers J.J. and R.I. Morimoto. "The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans. Proc Natl Acad Sci U S A. (2002). doi 10.1073/pnas.152161099
- Shen . X. . Ellis . R.E. . Lee . K. . Liu . C.-Y. . Yang . K. . Solomon . A. . Yoshida . H. . Morimoto . R. . Kurnit . D.M. . Mori . K. . Kaufman . R.J. . 2001 . Complementary Signaling Pathways Regulate the Unfolded Protein Response and Are Required for C. elegans Development . Cell . 107 . 7 . 893–903 . 10.1016/s0092-8674(01)00612-2 . 11779465 . 9165928 . free .
- Song . J. . Takeda . M. . Morimoto . R.I. . 2001 . Hsp70-Bag1 Complex Mediates a Physiological Stress Signaling Pathway that Regulates Raf-1/Erk and Cell Growth . Nature Cell Biology . 3 . 3 . 276–282 . 10.1038/35060068 . 11231577 . 9081104 .
- Thress . K. . Song . J. . Morimoto . R.I. . Kornbluth . S. . Reversible Inhibition of Hsp70 Chaperone Function by Scythe and Reaper . EMBO Journal . 2001 . 20 . 5 . 103–1041 . 10.1093/emboj/20.5.1033 . 11230127 . 145500 .
- Satyal . S. . Schmidt . E. . Kitagawa . K. . Sondheimer . N. . Lindquist . S. . Morimoto . R.I. . 2000 . Polyglutamine Aggregates Alter Protein Folding Homeostasis in C. elegans . Proc. Natl. Acad. Sci. USA . 97 . 11 . 5750–5755 . 10.1073/pnas.100107297 . 10811890 . 18505 . free .
- Shi . Y. D. Mosser . Morimoto . R.I. . 1998. Molecular Chaperones as HSF1 Specific Transcriptional Repressors . Genes & Development . 12 . 5 . 654–666 . 10.1101/gad.12.5.654 . 9499401 . 316571 . free .
- Morimoto . R.I. . 1998. Regulation of the Heat Shock Transcriptional Response: Crosstalk between a Family of Heat Shock Factors, Molecular Chaperones, and Negative Regulators . Genes & Development . 12 . 24 . 3788–3796 . 10.1101/gad.12.24.3788 . 9869631 . free .
- Kanei-Ishii . C. Tanikawa J. Nakai A. Morimoto R.I. . Ishii . S. . 1997. Activation of heat shock transcription factor 3 by c-Myb in the absence of cellular stress . Science . 277 . 5323. 246–8 . 10.1126/science.277.5323.246 . 9211854 .
- Freeman . B.C. . Toft . D. . Morimoto . R.I. . Chaperone Machines . Molecular . 1996 . Chaperone Activities of the Cyclophilin CyP-40 and the Steroid Aporeceptor Associated Protein p23 . Science . 274 . 5293 . 1718–1720 . 10.1126/science.274.5293.1718 . 8939864 . 333463 .
- Freeman . B.C. . Morimoto . R.I. . 1996. The Human Molecular Chaperones HSP90, HSP70 (HSC70) and HDJ-1 have Distinct Roles in Recognition of a Non-native Protein and Protein Refolding . EMBO Journal . 15 . 12 . 2969–2979 . 10.1002/j.1460-2075.1996.tb00660.x . free . 8670798 . 450238 .
- Lee . B. . Chen . J. . Jurivich . D. . Angelidis . C. . Morimoto . R.I. . 1995 . Pharmacological Modulation of the Heat Shock Factor Activity by Anti-Inflammatory Drugs Protects Against Stress-Induced Cellular Damage . Proc. Natl. Acad. Sci. USA . 92 . 16 . 7207–7211 . 10.1073/pnas.92.16.7207 . 7638169 . 41308 . free .
- Abravaya . K. . Myers . M. . Murphy . S. . Morimoto . R.I. . 1992. Human Heat Shock Protein HSP70 Interacts with HSF, the Transcription Factor That Regulates Heat Shock Gene Expression . Genes & Development . 6 . 7 . 1153–1164 . 10.1101/gad.6.7.1153 . 1628823 . free .
- Jurivich . D. . Sistonen . L. . Kroes . R. . Morimoto . R.I. . 1992 . Effects of Sodium Salicylate on the Human Heat Shock Response . Science . 255 . 5049 . 1243–1245 . 10.1126/science.1546322 . 1546322 . 1992Sci...255.1243J .
- Abravaya . K. . Phillips . B. . Morimoto . R.I. . 1991. Attenuation of the heat shock response in HeLa cells is mediated by the release of bound heat shock transcription factor and is modulated by changes in growth and in heat shock temperatures . Genes & Development . 5 . 11. 2117–27 . 10.1101/gad.5.11.2117 . 1936996 . free .
- Sarge . K. . Zimarino . V. . Holm . K. . Wu . C. . Morimoto . R.I. . 1991. Cloning and Characterization of Two Mouse Heat Shock Transcription Factors with Distinct Inducible and Constitutive DNA Binding Ability . Genes & Development . 5 . 10 . 1902–1911 . 10.1101/gad.5.10.1902 . 1717345 . free .
- Wu . B. . Hunt . C. . Morimoto . R.I. . 1985 . The Structure and Expression of the Human Gene Encoding the Major Heat Shock Protein HSP70 . Mol. Cell. Biol. . 5 . 2 . 330–341 . 10.1128/mcb.5.2.330 . 2858050 . 366716 . free .
In pop culture
In a YouTube video[5] published in 2009, members of the Morimoto lab showed C. elegans forming a smiley face on a culture plate. The video description jokes that when a post doc in the lab told them to smile, the C. elegans, lacking faces as individuals, formed the smiley face as a group, suggesting that they are intelligent, have ears, and can work in groups. In reality, the footage is playing in reverse: the C. elegans were placed into that formation on the plate by a human and then crawled away. By reversing the footage, it looks like the C. elegans spontaneously form a smiley face. The video manipulation is hinted at in the description that reminds the viewers that the YFP is brighter in the individuals' head than their tails.
External links
Notes and References
- 2015-01-01. A Conversation with Richard Morimoto. Cold Spring Harbor Symposia on Quantitative Biology. en. 80. 336–337. 10.1101/sqb.2015.80.030031. 0091-7451. 27325725. free.
- Limited. The Company of Biologists. 2014-01-01. Creating a path from the heat shock response to therapeutics of protein-folding diseases: an interview with Rick Morimoto. Disease Models & Mechanisms. en. 7. 1. 5–8. 10.1242/dmm.014753. 1754-8403. 24396148. 3882042.
- News: Professor Richard Morimoto - Proteostasis Symposium 2017. Proteostasis Symposium 2017. 2018-08-01. en-US.
- Web site: Professor Richard Morimoto awarded Les Palmes Académiques. Consulat Général de France à Chicago. en. 2018-08-01.
- Archived at Ghostarchive and the Wayback Machine: C. elegans knows you're watching! . YouTube.