Richard L. Lieber Explained

Rick Lieber
Birth Name:Richard L. Lieber
Birth Place:Walnut Creek, California
Fields:Physiology, Anatomy, Biology, Biomedical Engineering
Workplaces:Shirley Ryan AbilityLabNorthwestern University
Alma Mater:University of California, Davis (BS, Ph.D)University of California, San Diego (Postdoc, MBA)
Website:https://www.sralab.org/researchers/richard-lieber-phd

Richard (Rick) L. Lieber (born December 14, 1956) is an American scientist in the field of muscle physiology.[1] Lieber is Chief Scientific Officer and Senior Vice-president at Shirley Ryan AbilityLab, Professor of Physiology, Biomedical Engineering & Physical Medicine & Rehabilitation at Northwestern University's Feinberg School of Medicine,[2] [3] and Senior Research Career Scientist at the Edward Hines Jr. Veterans Administration Hospital.[4] He is internationally recognized as an expert in skeletal muscle structure and function.[5] [6] [7] His research focuses on skeletal muscle properties in individuals with neurological disorders such as spinal cord injury or cerebral palsy.[8] [9] [10] [11] [12]

Early life and education

Dr. Lieber was born in Walnut Creek, California, the son of a big band musician and hospital administrator. After graduation from Las Lomas High School in Walnut Creek, he completed a B.S. in physiology in 1978 at University of California, Davis.[13] In 1983, he earned his Ph.D. in biophysics from University of California, Davis, applied a theory of light diffraction to study mechanical properties of muscle cells[14] and was one of the first to use the Intel 8080 microprocessor to control a biological system in real-time.[15]   He received his M.B.A. in 2013 from Rady School of Management, University of California, San Diego.

Career

Lieber was hired as an assistant professor at UC San Diego in 1985, promoted to associate professor in 1990, and promoted to Professor in 1994. He was also a Biomedical Engineer at the Veterans Administration Medical Center in San Diego from 1983 to 2000. He was recruited as the Chief Scientific Officer at Shirley Ryan AbilityLab (formerly the Rehabilitation Institute of Chicago) in 2014 to lead the research enterprise in this new translational rehabilitation research hospital.

Research

Lieber has published over 350 articles in peer-reviewed scientific journals ranging from basic science such as The Journal of Cell Biology[16] to clinical research such as The Journal of Hand Surgery.[17] [18] [19] He is an established expert in using biological approaches to understand muscle contractures in neurological conditions such as cerebral palsy, stroke and spinal cord injury. Lieber's work includes the development of pharmacological and surgical interventions to improve muscle function in individuals with neurological conditions.[20] [21] [22] He has made significant contributions to the field of muscle physiology, especially in the area of in vivo muscle measurements,[23] [24] and he is frequently referenced by colleagues.[25] His most often cited paper is "Functional and clinical significance of skeletal muscle architecture" in the peer-reviewed journal Muscle & Nerve with 1447 citations. His work has over 34,000 citations in the scientific community and his h-index is 91.[26] In addition to his publications in peer-reviewed journals, he authored the textbook, "Skeletal Muscle Structure, Function, and Plasticity," which explores basic and applied physiological properties of skeletal muscle.[27]

Distinctions

Lieber's career is marked by significant professional collaborations with international colleagues and organizations, including Jan Fridén, M.D., Ph.D. at Gothenburg University,[28] [29] Eva Pontén at the Karolinska Institute,[30] and Allistair Rothwell at Christ Church, New Zealand.[31]

Lieber also serves as a member of the scientific advisory board of the NFL[32] and has six patents on surgical techniques, methods to measure muscle fibers, and methods to administer stimulation to skeletal muscles[33]

Awards and honors

Lieber has received a number of awards and honors throughout his career. These include:

Elsass Foundation Research Prize, June 2023[34] [35]

Paul B. Magnuson Award, Rehabilitation Research and Development, Department of Veterans Affairs, March 2023[36] [37]

Goel Award for Translational Biomechanics, North American Congress on Biomechanics (NACOB), American Society for Biomechanics, August 2022, Ottawa, Ontario, Canada.[38]

Lifetime Achievement Award, American Academy of Cerebral Palsy and Developmental Medicine,[39] [40] 2021

Fellow, Orthopaedic Research Society (ORS), November 2020[41] [42]

Fellow, American Institute of Medical and Biological Engineering (AIMBE), March 2019[43]

Hay Award in Sport Biomechanics, American Society of Biomechanics, August 2017[44]

Honorary Member, American Physical Therapy Association, February 2015[45]

Founders Award, American College of Sports Medicine (Southwest Chapter), October 2014.[46]

Gayle G. Arnold Award, American Academy of Cerebral Palsy and Developmental Medicine, October 2013

Kappa Delta Award, American Academy of Orthopaedic Surgeons, February 2013, Chicago, IL.[47] [48]

Fellow, American Society for Biomechanics, July 2012[49]

Outstanding Research Award, International Society for the Study of the Lumbar Spine (ISSLS), Göteborg, Sweden. June 2011.[50]

Giovanni Borelli Award, American Society of Biomechanics, August, 2007.[51]

The Göteborg University Medal, Sahlgrenska University Hospital, June 2007.[52]

Fulbright Scholarship (Sweden), 2007[53]

Nicolas Andry Award, American Bone and Joint Surgeons, Vancouver, British Columbia, Canada, May 2002[54] [55]

Fellow, American College of Sports Medicine, March, 1994.

Kappa Delta Young Investigator Award, American Academy of Orthopaedic Surgeons, February 1994.

Publications

Selected publications

  1. Lieber, R.L. and R.J. Baskin. (1983). Intersarcomere dynamics of single skeletal muscle fibers during fixed-end tetani. J. Gen. Physiol. 82:347-364. PMC2228698.
  2. Lieber, R.L., R.J. Baskin and Y. Yeh. (1984). Sarcomere length determination using laser diffraction: effect of beam and fiber diameter. Biophys. J. 45:1007-1016. PMC1434983.
  3. Lieber RL, Yeh Y, Baskin RJ. Sarcomere length determination using laser diffraction. Effect of beam and fiber diameter. Biophysical Journal. 1984;45:1007-16
  4. Lieber, R.L. and J.L. Boakes. (1988). Sarcomere length and joint kinematics during torque production in the frog hindlimb. Am. J. Physiol. 254:C759-C768. PMID3259840
  5. Lieber, R.L. and F.T. Blevins. (1989). Skeletal muscle architecture of the rabbit hindlimb: Functional implications of muscle design. J. Morphol. 199:93-101. PMID2921772
  6. Lieber, R.L., M.E. Leonard, C.G. Brown, and C.L. Trestik. (1991). Frog semitendinosis  tendon load-strain and stress-strain properties during passive loading. Am. J. Physiol. 261:C86-C92. PMID1858862
  7. Lieber, R.L., Raab, R., Kashin, S. and V.R. Edgerton (1992). Sarcomere length changes during fish swimming. J. Exp. Biol. 169:251-254. PMID11536506
  8. Lieber RL, Baskin RJ, Yeh Y.  (1984).  Sarcomere length determination using laser diffraction: effect of beam and fiber diameter. Biophys. J. 45:1007-1016. PMC 434983
  9. Lieber, R.L. G.J. Loren and J. Fridén. (1994). In vivo measurement of human wrist extensor muscle sarcomere length changes. J. Neurophysiol. 71:874-881. PMID8201427
  10. Sam M, Shah S, Fridén J, Milner DJ, Capetanaki Y, Lieber RL.  (2000). Desmin knockout muscles generate lower stress and are less vulnerable to injury compared to wildtype muscles.  Am. J. Physiol. 279:C1116-1122. PMID 1003592.
  11. Sam, M., S. Shah, J. Fridén, D.J. Milner, Y. Capetanaki and R.L. Lieber. (2000). Desmin knockout muscles generate lower stress and are less vulnerable to injury compared to wildtype muscles. Am. J. Physiol. 279:C1116-1122. PMID11003592
  12. Lieber, R.L. and J. Fridén. (2002). Spasticity causes a fundamental rearrangement of muscle-joint interaction. Muscle & Nerve 25:265-270. PMID11870696
  13. Lieber, R.L., J. Fridén, T. Hobbs, A.G. Rothwell. (2003). Analysis of posterior deltoid function one year after surgical restoration of elbow extension. J. Hand. Surg. (Am.) 28A:288-293. PMID 12671862.
  14. Patel, T.J., R. Das, J. Fridén, G.J. Lutz and R.L. Lieber. (2004). Sarcomere strain and heterogeneity correlate with injury to frog skeletal muscle fiber bundles. J. Appl. Physiol. 97:1803-1813. PMID15208284
  15. Lieber, R.L., W. Murray, D.L. Clark, V.R. Hentz and J. Fridén. (2005). Biomechanical properties of the brachioradialis muscle: Implications for surgical tendon transfer. J. Hand Surg. (Am.) 30:273-282. PMID15781349.
  16. Hentzen, E.R., M. Lahey, D. Peters, L. Mathew, I.A. Barash, J. Fridén and R.L. Lieber. (2006).  Stress-dependent and -independent expression of the myogenic regulatory factors and the MARP genes after eccentric contractions in rats. J. Physiol. (Lond.) 570:157-167. PMC1464283
  17. Smith, L.R., K.S. Lee, S.R. Ward, H.G. Chambers, R.L. Lieber. (2011) Hamstring contractures in children with spastic cerebral palsy result from a stiffer ECM and increased in vivo sarcomere length. J. Physiol. (Lond.) 589:2625-2639. PMID 21486759.
  18. Palmisano, M.G., S.N. Bremner, S. Huang, A.A. Domenighetti, T. Hornberger, S.B. Shah, M. Kellermeyer, A.F. Ryan, and R.L. Lieber. (2014). Skeletal muscle intermediate filaments  act as a stress-transmitting and stress-transducing signaling network. J. Cell Sci.128:219-224. PMC4294770
  19. Young KW, Radic S, Myslivets E, Lieber RL. (2014). Resonant reflection spectroscopy of biomolecular arrays in muscle.  Biophys. J. 107:2352-2360. PMID 25418304.
  20. Young, K.W., S. Radic, E. Myslivets, and R.L. Lieber. (2014). Resonant reflection spectroscopy of biomolecular arrays in muscle. Biophys. J. 107:2352-2360. PMC4241457.
  21. Palmisano, M.G., S.N. Bremner, A.A. Domenighetti, T. Hornberger, S.B. Shah, M. Kellermeyer, A.F. Ryan, and R.L. Lieber. (2014). Skeletal muscle intermediate filaments act as a stress-transmitting and stress-transducing signaling network. J. Cell Sci. 128:219-224. PMID 25413344.
  22. Mathewson, M.A., S.R. Ward, H.G. Chambers and R.L. Lieber. (2014). High resolution muscle measurements provide insight into equinus contracture in patients with cerebral palsy. J. Orthop Res. 33:33-39. PMC2903973
  23. Young, K.W., B.P.P Kuo, S.M. O'Connor, S. Radic and R.L. Lieber. (2017). In vivo sarcomere length measurement in whole muscles during passive stretch and twitch  contractions. Biophys. J. 112:805-812. PMID 28256239.
  24. Domenighetti, A., M.A. Mathewson, R. Pichika, L. Zhao, H.G. Chambers and R.L. Lieber. (2018). Loss of myogenic potential and fusion capacity of satellite cells isolated from contractured muscle in children with cerebral palsy. Am. J. Physiol. 315:C247-C257. PMID 29694232.

References

  1. Web site: Richard L. Lieber, PhD . 2023-11-06 . www.sralab.org . en.
  2. Web site: ORCID . 2023-11-06 . orcid.org.
  3. Web site: Faculty Profile . 2023-07-06 . www.feinberg.northwestern.edu . en.
  4. Web site: 2023-03-03 . Senior researcher at Illinois VA Hospital named 2023 VA Magnuson Award winner . 2023-11-06 . www.research.va.gov . en.
  5. Rehabilitation Institute of Chicago Names Richard Lieber as Chief Scientist and Senior Vice President of Research . 2023-11-06 . www.prnewswire.com . en.
  6. Web site: 2023-02-08 . Richard Lieber, PhD . 2023-11-06 . Cerebral Palsy Foundation . en.
  7. Web site: 2019-07-29 . Contributors . 2023-11-06 . IAACD . en-CA.
  8. Web site: Rady Alum wins the Paul B. Magnuson Award for Outstanding Achievement in Rehabilitation Research and Development . 2023-11-06 . rady.ucsd.edu.
  9. Son . Jongsang . Fridén . Jan . Lieber . Richard L. . 2022 . Biomechanical Modeling of Brachialis-to-Wrist Extensor Muscle Transfer Function for Daily Activities in Tetraplegia . JB & JS Open Access . 7 . 3 . e22.00018 . 10.2106/JBJS.OA.22.00018 . 2472-7245 . 9302328 . 35923813.
  10. Moreau . Noelle G. . Lieber . Richard L. . 2022 . Effects of voluntary exercise on muscle structure and function in cerebral palsy . Developmental Medicine and Child Neurology . 64 . 6 . 700–708 . 10.1111/dmcn.15173 . 1469-8749 . 9086177 . 35142371.
  11. Fridén . Jan . Stankovic . Nenad . Ward . Samuel R. . Lieber . Richard L. . 2022 . Increased muscle fiber size and pathology with botulinum toxin treatment of upper extremity muscles in cerebral palsy . Current Topics in Toxicology . 18 . 167–178 . 0972-8228 . 36999118. 10049878 .
  12. Winters . Taylor M. . Lim . Michael . Takahashi . Mitsuhiko . Fridén . Jan . Lieber . Richard L. . Ward . Samuel R. . 2021 . Surgical Mobilization of Skeletal Muscles Changes Functional Properties-Implications for Tendon Transfers . The Journal of Hand Surgery . 46 . 4 . 341.e1–341.e10 . 10.1016/j.jhsa.2020.09.017 . 1531-6564 . 33243591. 227181052 .
  13. Web site: Anderson . Jocelyn . 2021-11-22 . A Muscle Mission . 2023-11-06 . UC Davis Magazine . en-US.
  14. Web site: Institute for Bioelectronics - Northwestern University . 2023-11-06 . bioelectronics.northwestern.edu . en.
  15. Lieber . Richard L. . Roos . Kenneth P. . Lubell . Bradford A. . Cline . James W. . Baskin . Ronald J. . 1983 . High-Speed Digital Data Acquisition of Sarcomere Length from Isolated Skeletal and Cardiac Muscle Cells . IEEE Transactions on Biomedical Engineering . BME-30 . 1 . 50–57 . 10.1109/tbme.1983.325166 . 6826186 . 7408754 . 0018-9294.
  16. Gokhin . David S. . Lewis . Raymond A. . McKeown . Caroline R. . Nowak . Roberta B. . Kim . Nancy E. . Littlefield . Ryan S. . Lieber . Richard L. . Fowler . Velia M. . Velia Fowler . 2010-04-05 . Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology . The Journal of Cell Biology . 189 . 1 . 95–109 . 10.1083/jcb.201001125 . 1540-8140 . 2854367 . 20368620.
  17. Lieber . Richard L. . 2008-11-01 . Biology and Mechanics of Skeletal Muscle: What Hand Surgeons Need to Know When Tensioning a Tendon Transfer . The Journal of Hand Surgery . 33 . 9 . 1655–1656 . 10.1016/j.jhsa.2008.08.010 . 18984353 . 0363-5023.
  18. Web site: Lieber, Richard L. Learning For Life . 2023-11-06 . www.nulearningforlife.org.
  19. Web site: My Bibliography - NCBI . 2023-11-06 . www.ncbi.nlm.nih.gov . en.
  20. Web site: 2020-09-29 . Clinical repurposing trials for COVID-19 and cerebral palsy underway in Chicago; trials at the University of Chicago, Northwestern University and Shirley Ryan AbilityLab demonstrate Chicago's continued biomedical strength . 2023-11-06 . Daily Herald . en-US.
  21. Web site: 2018-04-26 . Cancer Drug Shows Promise in Treatment of Cerebral Palsy . 2023-11-06 . www.sralab.org . en.
  22. Gardenier . Jason . Garg . Rohit . Mudgal . Chaitanya . 2020 . Upper Extremity Tendon Transfers: A Brief Review of History, Common Applications, and Technical Tips . Indian Journal of Plastic Surgery. 53 . 2 . 177–190 . 10.1055/s-0040-1716456 . 0970-0358 . 7458847 . 32884184.
  23. Book: Iyer . Shama R. . Valencia . Ana P. . Hernández-Ochoa . Erick O. . Lovering . Richard M. . Skeletal Muscle Regeneration in the Mouse . 2016 . In Vivo Assessment of Muscle Contractility in Animal Studies . Methods in Molecular Biology (Clifton, N.J.) . 1460 . 293–307 . 10.1007/978-1-4939-3810-0_20 . 1064-3745 . 5500964 . 27492180. 978-1-4939-3808-7 .
  24. Đorđević . Srđan . Tomažič . Sašo . Narici . Marco . Pišot . Rado . Meglič . Andrej . 2014-09-25 . In-Vivo Measurement of Muscle Tension: Dynamic Properties of the MC Sensor during Isometric Muscle Contraction . Sensors (Basel, Switzerland) . 14 . 9 . 17848–17863 . 10.3390/s140917848 . 1424-8220 . 4208254 . 25256114 . 2014Senso..1417848D . free .
  25. Web site: November 6, 2023 . Richard L. Lieber . Research.com.
  26. Web site: Richard Lieber . 2023-11-06 . scholar.google.com.
  27. Book: Lieber, Richard L. . Skeletal Muscle Structure, Function, and Plasticity . 2002 . Lippincott Williams & Wilkins . 978-0-7817-3061-7 . en.
  28. Web site: Jan Friden University of Gothenburg . 2023-11-06 . www.gu.se . en.
  29. Web site: 2021-09-02 . Dr. Lieber and Dr. Son Publish Results of Groundbreaking Reconstructive Surgery to Improve Hand Function After Tetraplegia . 2023-11-06 . www.sralab.org . en.
  30. Web site: Eva Pontén Staff Portal . 2023-11-06 . staff.ki.se . en.
  31. Web site: Otago . University of . 2023-08-02 . Profile . 2023-11-06 . www.otago.ac.nz . en.
  32. Web site: NFL.com Official Site of the National Football League . 2023-11-06 . NFL.com . en-US.
  33. Web site: Google Patents . 2023-11-06 . patents.google.com.
  34. Web site: 2023-03-27 . American researcher receives the Research Prize . 2023-11-06 . www.elsassfonden.dk . en.
  35. Web site: 2023-03-28 . Dr. Rick Lieber Receives 2023 Elsass Foundation Research Prize for Impacting Lives of People with CP . 2023-11-06 . www.sralab.org . en.
  36. Web site: 2023-03-03 . Hines VA senior research scientist receives Magnuson Award VA Hines health care . 2023-11-06 . Veterans Affairs . en.
  37. Web site: 2023-03-13 . Lieber Receives VA Rehabilitation Research and Development Award . 2023-11-06 . News Center . en-US.
  38. Web site: Society Awards . 2023-11-06 . American Society of Biomechanics . en-US.
  39. Web site: AACPDM Awards AACPDM . 2023-07-06 . American Academy for Cerebral Palsy and Developmental Medicine . en.
  40. Web site: Marrush . Najwa . 2021-10-05 . Biophysics Alum to receive AACPDM Lifetime Achievement Award . 2023-07-06 . Biophysics Graduate Group . en.
  41. Web site: Blake . Amber . ORS Fellows . 2023-11-06 . ORS . en-US.
  42. Web site: 2021-02-15 . Dr. Richard Lieber Honored as Fellow of the Orthopaedic Research Society . 2023-11-06 . www.sralab.org . en.
  43. Web site: Richard Lieber Dr. Richard Lieber Inducted into Medical and Biological Engineering Elite - AIMBE . 2023-11-06 . en.
  44. Web site: 2017-07-26 . American Society of Biomechanics Newsletter by ASB web - Issuu . 2023-11-06 . issuu.com . en.
  45. Web site: From the House of Delegates: APTA Honors Richard Lieber With Honorary Membership – Alaska Physical Therapy Association . 2023-11-06 . en-US.
  46. Web site: Pathways.org Medical Roundtable . 2023-11-06 . Pathways.org . en-US.
  47. https://www.aaos.org/globalassets/quality-and-practice-resources/research-resources/kappa-delta/kappa-delta-oref-winners-1950-2020.pdf
  48. Web site: Kappa Delta award recognizes research in muscle architecture . 2023-11-06 . galeapps.gale.com.
  49. Web site: Fellows . 2023-11-06 . American Society of Biomechanics . en-US.
  50. Web site: PREVIOUS ISSLS PRIZE AWARDS . 2023-11-06 . The International Society for the Study of the Lumbar Spine . en-AU.
  51. Web site: Meeting Awards . 2023-07-06 . American Society of Biomechanics . en-US.
  52. Web site: Jan Fridén receives prestigious research prize . 2023-07-06 . akademiliv.se.
  53. Web site: Richard Lieber Fulbright Scholar Program . 2023-11-06 . fulbrightscholars.org.
  54. Web site: Cindy . 2016-05-04 . Skeletal Muscle Design and Plasticity #48 . 2023-07-06 . ACRM . en-US.
  55. Web site: ABJS/CORR Nicolas Andry Award Winners . 2023-11-06 . www.abjs.org.

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