Ribonucleotide reductase inhibitor explained

Ribonucleotide reductase inhibitors are a family of anti-cancer drugs that interfere with the growth of tumor cells by blocking the formation of deoxyribonucleotides (building blocks of DNA).

Examples include:

• motexafin gadolinium.^[1]
• hydroxyurea^[2]
• fludarabine, cladribine, gemcitabine, tezacitabine, and triapine^[3]
• gallium maltolate, gallium nitrate^[4]
• Tezacitabine, Tezacitabine^[5] A chemotherapy candidate nucleotide analogue that failed in clinical trials due to on-target toxicity (febrile neutropenia).^[6]

See also

• Ribonucleotide reductase

External links

• Ribonucleotide reductase inhibitor entry in the public domain NCI Dictionary of Cancer Terms

Notes and References

1. Zahedi Avval F, Berndt C, Pramanik A, Holmgren A . Mechanism of inhibition of ribonucleotide reductase with motexafin gadolinium (MGd) . Biochem. Biophys. Res. Commun. . 379. 3. 775–9. January 2009 . 19121624 . 10.1016/j.bbrc.2008.12.128 .
2. Mayhew CN, Phillips JD, Cibull ML, Elford HL, Gallicchio VS . Short-term treatment with novel ribonucleotide reductase inhibitors Trimidox and Didox reverses late-stage murine retrovirus-induced lymphoproliferative disease with less bone marrow toxicity than hydroxyurea . Antivir. Chem. Chemother. . 13 . 5 . 305–14 . September 2002 . 12630679 . 10.1177/095632020201300506. free .
3. Tsimberidou AM, Alvarado Y, Giles FJ . Evolving role of ribonucleoside reductase inhibitors in hematologic malignancies . Expert Rev Anticancer Ther . 2 . 4 . 437–48 . August 2002 . 12647987 . 10.1586/14737140.2.4.437 . 30047759 .
4. Bernstein LR . Mechanisms of therapeutic activity for gallium . Pharmacol. Rev. . 1998 . 50 . 665–682 . 9860806 . 4.
5. Regression of human breast tumor xenografts in response to (E)-2'-deoxy-2'-(fluoromethylene)cytidine, an inhibitor of ribonucleoside diphosphate reductase . 8137252 . Cancer Research . 15 March 1994 . 54 . 6 . 1485–1490 . Bitonti . A. J. . Dumont . J. A. . Bush . T. L. . Cashman . E. A. . Cross-Doersen . D. E. . Wright . P. S. . Matthews . D. P. . McCarthy . J. R. . Kaplan . D. A. .
6. Web site: Tezacitabine monohydrate .