Ribonucleoside-triphosphate reductase explained

Ribonucleoside-triphosphate reductase
Ec Number:	1.17.4.2
Cas Number:	9068-66-0
Width:	270

Ribonucleoside-triphosphate reductase (ribonucleotide reductase, 2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase) is an enzyme with systematic name 2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase.^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H₂O

\rightleftharpoons ribonucleoside triphosphate + thioredoxin

Ribonucleoside-triphosphate reductase requires a cobamide coenzyme and ATP.

Notes and References

1. Blakley RL . Cobamides and ribonucleotide reduction. I. Cobamide stimulation of ribonucleotide reduction in extracts of Lactobacillus leichmannii . The Journal of Biological Chemistry . 240 . 2173–80 . May 1965 . 14299643 .
2. Goulian M, Beck WS . Purification and properties of cobamide-dependent ribonucleotide reductase from Lactobacillus leichmannii . The Journal of Biological Chemistry . 241 . 18 . 4233–42 . September 1966 . 5924645 .
3. The ribonucleotide reductases - a unique group of metalloenzymes essential for cell-proliferation . Lammers, M. . Follmann, H. . Struct. Bonding . 1983 . 54 . 27–91 . 10.1007/bfb0111318.