RHPN2 explained

Rhophilin-2 is a protein that in humans is encoded by the RHPN2 gene.^{[1] [2]}

Interactions

RHPN2 has been shown to interact with RHOB.^[3]

Further reading

• Mircescu H, Steuve S, Savonet V, Degraef C, Mellor H, Dumont JE, Maenhaut C, Pirson I . Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP . Eur. J. Biochem. . 269 . 24 . 6241–9 . 2002 . 12473120 . 10.1046/j.1432-1033.2002.03343.x . 23901713 .
• Jaffe AB, Aspenström P, Hall A . Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways . Mol. Cell. Biol. . 24 . 4 . 1736–46 . 2004 . 14749388 . 344169 . 10.1128/MCB.24.4.1736-1746.2004 .
• Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL . High-throughput mapping of a dynamic signaling network in mammalian cells . Science . 307 . 5715 . 1621–5 . 2005 . 15761153 . 10.1126/science.1105776 . 2005Sci...307.1621B . 39457788 .
• Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H . Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer . Mol. Cell. Proteomics . 4 . 6 . 785–95 . 2005 . 15778465 . 10.1074/mcp.M500021-MCP200 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Zhan X, Desiderio DM . Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry . Anal. Biochem. . 354 . 2 . 279–89 . 2006 . 16777052 . 10.1016/j.ab.2006.05.024 .
• Steuve S, Devosse T, Lauwers E, Vanderwinden JM, André B, Courtoy PJ, Pirson I . Rhophilin-2 is targeted to late-endosomal structures of the vesicular machinery in the presence of activated RhoB . Exp. Cell Res. . 312 . 20 . 3981–9 . 2006 . 17054945 . 10.1016/j.yexcr.2006.08.028 .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .

Notes and References

1. Peck JW, Oberst M, Bouker KB, Bowden E, Burbelo PD . The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization . J. Biol. Chem. . 277 . 46 . 43924–32 . November 2002 . 12221077 . 10.1074/jbc.M203569200 . free .
2. Web site: Entrez Gene: RHPN2 rhophilin, Rho GTPase binding protein 2.
3. Mircescu H, Steuve S, Savonet V, Degraef C, Mellor H, Dumont JE, Maenhaut C, Pirson I . Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP . Eur. J. Biochem. . 269 . 24 . 6241–9 . December 2002 . 12473120 . 10.1046/j.1432-1033.2002.03343.x . 23901713 .