Rhodosporidiobolus fluvialis is a species of fungus in the family Sporidiobolaceae. It is a human fungal pathogen that exhibits resistance to antifungal compounds like fluconazole and caspofungin.[1]
Rhodosporidiobolus fluvialis was isolated from two independent patients. It can proliferate well at, a temperature similar to the human body's internal temperature. When it is incubated at, reactive oxygen species accumulate and damage its DNA, which causes mutations that lead to the development of resistance to amphotericin-B.[2]
R. fluvialis colonies can be pigmented due to the accumulation of carotenoids in the cells. Carotenoid production has been associated with its resistance to caspofungin.