Rhodopsin-like receptors explained
Rhodopsin-like receptors are a family of proteins that comprise the largest group of G protein-coupled receptors.[1]
Scope
G-protein-coupled receptors, GPCRs, constitute a vast protein family that encompasses a wide range of functions (including various autocrine, paracrine, and endocrine processes). They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups. GPCRs are usually described as "superfamily" because they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence.[1] The currently known superfamily members include the rhodopsin-like GPCRs (this family), the secretin-like GPCRs, the cAMP receptors, the fungal mating pheromone receptors, and the metabotropic glutamate receptor family. There is a specialised database for GPCRs.[2]
Function
The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone, neuropeptide, neurotransmitter, and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character, the amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7 transmembrane (TM) helices.[3] [4] [5]
Classes
Rhodopsin-like GPCRs have been classified into the following 19 subgroups (A1-A19) based on a phylogenetic analysis.[6]
Subfamily A1
Subfamily A2
Subfamily A3
Subfamily A4
Subfamily A5
Subfamily A6
Subfamily A7
Subfamily A8
Subfamily A9
Subfamily A10
Subfamily A11
Subfamily A12
Subfamily A13
Subfamily A14
Subfamily A15
Subfamily A16
Subfamily A17
Subfamily A18
Subfamily A19
Unclassified
External links
- Web site: GPCRDB (G Protein-Coupled Receptor Data Base): sequence-derived data. . 2007-12-10 . Vriend G, Horn F, Oliveira L, Bywater RP, Cohen FE . https://web.archive.org/web/20071114110706/http://www.gpcr.org/7tm/multali/multali.html . 2007-11-14 . dead .
- Horn F, Bettler E, Oliveira L, Campagne F, Cohen FE, Vriend G . GPCRDB information system for G protein-coupled receptors . Nucleic Acids Res. . 31 . 1 . 294–7 . 2003 . 12520006 . 10.1093/nar/gkg103 . 165550 . This database includes multiple sequence alignments of all GPCR families and sub-families.
Notes and References
- Attwood TK, Findlay JB . Fingerprinting G-protein-coupled receptors . Protein Eng. . 7 . 2 . 195–203 . 1994 . 8170923 . 10.1093/protein/7.2.195.
- Web site: Information system for G protein-coupled receptors . GPCRDB . www.gpcr.org . 2008-12-05 . dead . https://web.archive.org/web/20090422020837/http://www.gpcr.org/7tm/data/ . 2009-04-22 .
- Birnbaumer L . G proteins in signal transduction . Annu. Rev. Pharmacol. Toxicol. . 30 . 675–705 . 1990. 2111655 . 10.1146/annurev.pa.30.040190.003331.
- Gilman AG, Casey PJ . G protein involvement in receptor-effector coupling . J. Biol. Chem. . 263 . 6 . 2577–2580 . 1988. 10.1016/S0021-9258(18)69103-3 . 2830256 . free .
- Attwood TK, Findlay JB . Design of a discriminating fingerprint for G-protein-coupled receptors . Protein Eng. . 6 . 2 . 167–176 . 1993 . 8386361 . 10.1093/protein/6.2.167.
- Joost P, Methner A . Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands . Genome Biol . 2002 . 3 . 11 . research0063.1–0063.16 . 12429062 . 10.1186/gb-2002-3-11-research0063 . 133447 . free .
- Terakita A . The opsins . Genome Biol. . 6 . 3 . 213 . 2005 . 15774036 . 10.1186/gb-2005-6-3-213 . 1088937 . free .
- Nordström KJ, Sällman Almén M, Edstam MM, Fredriksson R, Schiöth HB . Independent HHsearch, Needleman—Wunsch-based, and motif analyses reveal the overall hierarchy for most of the G protein-coupled receptor families . Molecular Biology and Evolution . 28 . 9 . 2471–80 . September 2011 . 21402729 . 10.1093/molbev/msr061. free .