RhoGAP domain explained

RhoGAP domain is an evolutionary conserved protein domain of GTPase activating proteins towards Rho/Rac/Cdc42-like small GTPases.

Human proteins containing this domain

ABR

ARHGAP1; ARHGAP10; ARHGAP11A; ARHGAP11B; ARHGAP12; ARHGAP15; ARHGAP17;ARHGAP18

ARHGAP19; ARHGAP20; ARHGAP21; ARHGAP22; ARHGAP23; ARHGAP24; ARHGAP25;ARHGAP26

ARHGAP27; ARHGAP28; ARHGAP29; ARHGAP30; ARHGAP4; ARHGAP5; ARHGAP6;ARHGAP8

ARHGAP9; BCR; BPGAP1; C1; C5orf5; CDGAP; CENTD1;CENTD2

CENTD3; CHN1; CHN2; DEPDC1; DEPDC1A; DEPDC1B; DLC1;FAM13A1

FKSG42; GMIP; GRLF1; HMHA1; INPP5B; KIAA1688; LOC553158;MYO9A

MYO9B; OCRL; OPHN1; PIK3R1; PIK3R2; PRR5; RACGAP1;RACGAP1P

RALBP1; RICH2; RICS; SH3BP1; SLIT1; SNX26; SRGAP1;SRGAP2

SRGAP3; STARD13; STARD8; SYDE1; SYDE2;

References

• Musacchio . A. . Cantley . L. C. . Harrison . S. C. . Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit . Proceedings of the National Academy of Sciences of the United States of America . 93 . 25 . 14373–14378 . 1996 . 8962058 . 26139 . 10.1073/pnas.93.25.14373. free .
• Barrett . T. . Xiao . B. . Dodson . E. J. . Dodson . G. . Ludbrook . S. B. . Nurmahomed . K. . Gamblin . S. J. . Musacchio . A. . Smerdon . S. J. . 10.1038/385458a0 . Eccleston . J. F. . The structure of the GTPase-activating domain from p50rhoGAP . Nature . 385 . 6615 . 458–461 . 1997 . 9009196 . 4235645 .
• Gamblin . S. J. . Rittinger . K. . Walker . P. A. . Eccleston . J. F. . Nurmahomed . K. . Owen . D. . Laue . E. . Smerdon . S. J. . Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP . Nature . 388 . 6643 . 693–697 . 10.1038/41805 . 1997 . 9262406 . 4415826 . free .
• Boguski . M. S. . McCormick . F. . 10.1038/366643a0 . Proteins regulating Ras and its relatives . Nature . 366 . 6456 . 643–654 . 1993 . 8259209 . 4338237 .