Rhaponticin Explained

Rhaponticin is a stilbenoid glucoside compound. Its aglycone is called rhapontigenin. It can be found in rhubarb rhizomes.^[1]

It has beneficial effects on diabetic mice,^[1] and in vitro results suggest it may be relevant to Alzheimer's disease with an action on beta amyloid.^[2] It is a phytoestrogen and has estrogenic activity.^{[3] [4]}

Notes and References

1. Chen . Jinlong . Ma . Mengmeng . Lu . Yanwei . Wang . Lisheng . Wu . Chutse . Duan . Haifeng . Rhaponticin from Rhubarb Rhizomes Alleviates Liver Steatosis and Improves Blood Glucose and Lipid Profiles in KK/Ay Diabetic Mice . Planta Medica . 75 . 5 . 472–7 . 2009 . 19235684 . 10.1055/s-0029-1185304.
2. Misiti . F . Sampaolese . B . Mezzogori . D . Orsini . F . Pezzotti . M . Giardina . B . Clementi . M . Protective effect of rhubarb derivatives on amyloid beta (1–42) peptide-induced apoptosis in IMR-32 cells: A case of nutrigenomic . Brain Research Bulletin . 71 . 1–3 . 29–36 . 2006 . 17113925 . 10.1016/j.brainresbull.2006.07.012. 31748806 .
3. Book: Nirali Prakashan. Pharmacognosy. 2009. Nirali Prakashan. 978-81-963961-5-2. 8–.
4. Book: Andrea R. Genazzani. Basil C. Tarlatzis. Frontiers in Gynecological Endocrinology: Volume 3: Ovarian Function and Reproduction - From Needs to Possibilities. 1 December 2015. Springer. 978-3-319-23865-4. 178–.