Reza Dana Explained

Occupation:Claes H. Dohlman Chair of Ophthalmology, W. Clement Stone Clinical Research Scholar Harvard Medical School
Education:St. Paul's School
Johns Hopkins University (BA, MD, MPH)
Illinois Eye and Ear Infirmary (residency)
Wills Eye Hospital
Massachusetts Eye and Ear
Harvard University (MSc)
Field:Medical research,
Immunology
Ophthalmology
Work Institution:Massachusetts Eye and Ear
Massachusetts General Hospital
Brigham and Women's Hospital
Harvard Medical School
Harvard University
Alma Mater:St. Paul's School
Johns Hopkins University
Illinois Eye and Ear Infirmary
Wills Eye Hospital
Harvard Medical School
Known For:Dry Eye Disease
Corneal Transplantation Research

Reza Dana is the Claes H. Dohlman Professor of Ophthalmology, senior scientist and W. Clement Stone Clinical Research Scholar at Massachusetts Eye and Ear, Harvard Medical School, and director of the Harvard-Vision Clinical Scientist Development Program.[1]

Dana is an internationally recognized expert in the field of corneal disorders and ocular inflammation. He is best known for his work on the molecular and cellular mechanisms of ocular inflammation with translational applications to autoimmunity, transplantation, dry eye disease, and angiogenesis.[2] He is a member of editorial boards of 10 journals, including as editor-in-chief of Cornea.[3] [4]

Education and training

Dana attended the Tehran International School during his early years and graduated summa cum laude from St. Paul's School, New Hampshire.[5] He pursued his baccalaureate degree at Johns Hopkins University School of Arts and Sciences, where he was invited to join the Phi Beta Kappa. Dr. Dana attended medical school at Johns Hopkins School of Medicine, and also obtained a master's degree in Public Health from Johns Hopkins Bloomberg School of Public Health. He received his Ophthalmology residency training at the Illinois Eye and Ear Infirmary, and clinical cornea and external diseases fellowship at Wills Eye Hospital in Philadelphia. He received advanced fellowship training in Immunology and Uveitis at the Massachusetts Eye and Ear and pursued laboratory research training in Ocular and Transplantation Immunology Laboratory at the Schepens Eye Research Institute, Harvard Medical School under the mentorship of the late J. Wayne Streilein.[6]

Research and career

Dana joined as an instructor in the department of ophthalmology at Harvard Medical School in 1995 and has been a faculty member here ever since. In 2006, he was named the director of Cornea Service at Massachusetts Eye and Ear, and in 2007, he was appointed the Claes H. Dohlman Chair in Ophthalmology and vice chairman for academic programs. He is also an honorary professor of ophthalmology at Shanghai Medical College, Fudan University.[7]

Dana's research focus is in the area of immuno-inflammatory disorders of the cornea and ocular surface. He has published over 370 peer-reviewed publications and over 150 reviews, edited several books and serves as the senior editor for Elsevier's Encyclopedia of the Eye.[8] [9] His work has been cited more than 25000 times and carries an h-index of 82.[10] His is widely recognized for (i) identifying, phenotyping and functionally characterizing resident bone marrow-derived antigen-presenting cells (APC) of the cornea,[11] (ii) identifying novel mechanisms of corneal APC trafficking,[12] (iii) defining novel functional interactions between lymphatic endothelia and APC,[13] (iv) identifying selective topical cytokine and chemokine targeting to promote transplant survival by suppressing effector T cells,[14] [15] [16] [17] (v) defining novel mechanisms employed by the corneal epithelium to maintain angiogenic privilege including the VEGFR-3 sink[18] and PD-L1 mechanisms,[19] (vi) developing strategies to promote corneal endothelial cell survival in transplantation, including gene therapy.[20] [21]

Awards and honors

Teaching and Mentoring

Dana is the vice chair of academic programs at the Department of Ophthalmology, Massachusetts Eye and Ear and a faculty for the Graduate Program in Immunology, Harvard Medical School.[2] He is the recipient of the Harvard Medical School Clifford Barger Excellence in Mentoring Award, the top mentoring award bestowed at Harvard Medical School.[30] He has mentored over 120 postdoctoral research fellows from 33 countries, 80 clinical fellows and residents, medical students, and graduate students enrolled in Harvard Medical School. He is the director of the NIH-funded Harvard-Vision Clinical Scientist Development Program since 2004.[43]

Notes and References

  1. Web site: Research Profile: Reza Dana, M.D., M.Sc., MPH Mass. Eye and Ear. www.masseyeandear.org. 2020-10-20.
  2. https://researchers.masseyeandear.org/details/12 Research Profile: Reza Dana, MD, MSc, MPH
  3. Dana. Reza. Letter From the New Editor-in-Chief. Cornea. 39. 1. 1. 10.1097/ICO.0000000000002231. 1536-4798. 31764283. 2020. 208275145.
  4. Web site: Reza Dana, MD, MSc, MPH, FARVO. eye.hms.harvard.edu. 2020-10-20.
  5. News: Reza Dana: Success Begins Outside Your Comfort Zone. Memarian, Jahandad. September 14, 2017. HuffPost. 2020-10-20.
  6. Streilein. J. Wayne. 2004-03-01. Introducing Reza Dana, the 2003 Recipient of the Cogan Award. Investigative Ophthalmology & Visual Science. 45. 3. 721. 10.1167/iovs.03-0509. 1552-5783.
  7. Web site: Dana CV. 2019-11-10. https://web.archive.org/web/20191108204009/http://www.schepens.harvard.edu/images/stories/faculty/dana/documents/dana_cv.pdf. 2019-11-08. dead.
  8. Web site: Pubmed Bibliography. Dana. Reza. National Library of Medicine.
  9. Book: Dana, Reza. Encyclopedia of the Eye. Elsevier. 2010. 978-0-12-374198-1.
  10. Web site: Google Scholar.
  11. Hamrah. Pedram. Huq. Syed O.. Liu. Ying. Zhang. Qiang. Dana. M. Reza. 2003. Corneal immunity is mediated by heterogeneous population of antigen-presenting cells. Journal of Leukocyte Biology. 74. 2. 172–178. 10.1189/jlb.1102544. 0741-5400. 12885933. 15964172.
  12. Liu. Ying. Hamrah. Pedram. Zhang. Qiang. Taylor. Andrew W.. Dana. M. Reza. 2002-01-21. Draining Lymph Nodes of Corneal Transplant Hosts Exhibit Evidence for Donor Major Histocompatibility Complex (MHC) Class II–positive Dendritic Cells Derived from MHC Class II–negative Grafts. The Journal of Experimental Medicine. 195. 2. 259–268. 10.1084/jem.20010838. 0022-1007. 2193609. 11805152.
  13. Chen. Lu. Hamrah. Pedram. Cursiefen. Claus. Zhang. Qiang. Pytowski. Bronislaw. Streilein. J. Wayne. Dana. M. Reza. 2004. Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity. Nature Medicine. 10. 8. 813–815. 10.1038/nm1078. 1078-8956. 15235599. 1449221.
  14. Huq. Syed. Liu. Ying. Benichou. Gilles. Dana. M. Reza. 2004-10-01. Relevance of the Direct Pathway of Sensitization in Corneal Transplantation Is Dictated by the Graft Bed Microenvironment. The Journal of Immunology. 173. 7. 4464–4469. 10.4049/jimmunol.173.7.4464. 0022-1767. 15383577.
  15. Hattori. Takaaki. Saban. Daniel R.. Emami-naeini. Parisa. Chauhan. Sunil K.. Funaki. Toshinari. Ueno. Hiroki. Dana. Reza. 2012. Donor-derived, tolerogenic dendritic cells suppress immune rejection in the indirect allosensitization-dominant setting of corneal transplantation. Journal of Leukocyte Biology. 91. 4. 621–627. 10.1189/jlb.1011500. 1938-3673. 3317274. 22291211.
  16. Dohlman. Thomas. Omoto. Masahiro. Hua. Jing. Stevenson. William. Lee. Sang-Mok. Chauhan. Sunil. Dana. Reza. 2015. VEGF-trap Aflibercept Significantly Improves Long-term Graft Survival in High-risk Corneal Transplantation. Transplantation. ENGLISH. 99. 4. 678–686. 10.1097/TP.0000000000000512. 0041-1337. 25606789. 26944722. free.
  17. Amouzegar. Afsaneh. Chauhan. Sunil K.. Dana. Reza. 2016-05-15. Alloimmunity and Tolerance in Corneal Transplantation. The Journal of Immunology. en. 196. 10. 3983–3991. 10.4049/jimmunol.1600251. 0022-1767. 27183635. 4874505.
  18. Cursiefen. Claus. Chen. Lu. Saint-Geniez. Magali. Hamrah. Pedram. Jin. Yiping. Rashid. Saadia. Pytowski. Bronislaw. Persaud. Kris. Wu. Yan. Streilein. J. Wayne. Dana. Reza. 2006-07-25. Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision. Proceedings of the National Academy of Sciences of the United States of America. 103. 30. 11405–11410. 10.1073/pnas.0506112103. 0027-8424. 1544098. 16849433. 2006PNAS..10311405C. free.
  19. Shen. Linling. Jin. Yiping. Freeman. Gordon J.. Sharpe. Arlene H.. Dana. M. Reza. 2007-09-15. The function of donor versus recipient programmed death-ligand 1 in corneal allograft survival. Journal of Immunology . 179. 6. 3672–3679. 10.4049/jimmunol.179.6.3672. 0022-1767. 17785803. free.
  20. Fuchsluger. T. A.. Jurkunas. U.. Kazlauskas. A.. Dana. R.. 2011. Anti-apoptotic gene therapy prolongs survival of corneal endothelial cells during storage. Gene Therapy. 2011. 18. 8. 778–787. 10.1038/gt.2011.20. 1476-5462. 3587653. 21412281.
  21. Fuchsluger. Thomas A.. Jurkunas. Ula. Kazlauskas. Andrius. Dana. Reza. 2011. Corneal endothelial cells are protected from apoptosis by gene therapy. Human Gene Therapy. 22. 5. 549–558. 10.1089/hum.2010.079. 1557-7422. 3081440. 21158568.
  22. Web site: Heed Fellows The Heed Foundation. www.heed.org. 2020-10-20.
  23. Web site: Honors and Distinctions - Schepens Eye Research Institute of Mass. Eye and Ear. www.schepens.harvard.edu. 2019-11-10. https://web.archive.org/web/20191110100005/https://masseyeandear.org/research/ophthalmology/serihonors-and-distinctions/faculty/honors-and-distinctions.html. 2019-11-10. dead.
  24. Web site: Reza Dana Harvard Catalyst Profiles Harvard Catalyst. connects.catalyst.harvard.edu. 2020-10-20.
  25. Web site: Alcon Research Institute Past Grant Recipients MyAlcon.com. www.myalcon.com. 2019-11-10. 2019-11-10. https://web.archive.org/web/20191110162603/https://www.myalcon.com/professional/alcon-research-development/institute-partnerships/past-grant-recipients. dead.
  26. Web site: Ever Association. www.everassociation.org. 2020-10-20.
  27. Web site: LSUHSC School of Medicine. www.medschool.lsuhsc.edu. 2020-10-20.
  28. Web site: The Association for Research in Vision and Ophthalmology- 2013 ARVO Fellows. www.arvo.org. 2020-10-20.
  29. Web site: Ocular Microbiology and Immunology Group, Inc.. Ocular Microbiology and Immunology Group, Inc.. 2020-10-20.
  30. Web site: A. Clifford Barger Excellence in Mentoring Award Recipients. The Office for Diversity Inclusion and Community Partnership at Harvard Medical School. 2020-10-20.
  31. News: Reza Dana, MD, MSc, MPH, Receives Kersley Medal. eye.hms.harvard.edu. 2020-10-20.
  32. Web site: Roger F. Meyer Lectureship in Cornea Ophthalmology Michigan Medicine. 2017-08-28. Ophthalmology. 2020-10-20.
  33. News: Reza Dana Elected to Academia Ophthalmologica Internationalis. eye.hms.harvard.edu. 2020-10-20.
  34. Web site: Honorary Lectures + ICO Medal Winners Eye Doctors ©2019. entertainment.ie. 2019-11-10.
  35. Web site: Dr. Reza Dana to Receive 2016 Endre A. Balazs Prize. eye.hms.harvard.edu. 2016-04-28. 2020-10-20.
  36. Web site: The 121st Annual Meeting of the Japanese Ophthalmological Society. convention.jtbcom.co.jp. 2020-10-20.
  37. Web site: Reza Dana receives Senior Achievement Award from AAO. eye.hms.harvard.edu. 2020-10-20.
  38. Jurkunas. Ula. 30th Biennial Cornea Conference. Grantome.
  39. News: Dr. Reza Dana to receive Friedenwald Award from the Association for Research in Vision and Ophthalmology. eye.hms.harvard.edu. 2017-06-02. 2019-11-10.
  40. News: Reza Dana, MD, MSc, MPH, Awarded Research to Prevent Blindness Stein Innovation Award. eye.hms.harvard.edu. 2018-06-25. 2020-10-20.
  41. Web site: 2019 Ellis Island Medal of Honor Recipients. eihonors.org. 2020-10-20. 2019-07-15. https://web.archive.org/web/20190715102613/http://eihonors.org/medal-of-honor/2019-medalists. dead.
  42. Web site: Reza Dana. The Ophthalmologist. 2020-10-20.
  43. Web site: Reza Dana, MD, MSc, MPH. Harvard Medical School. 2020-10-20.

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