Revospirone Explained

Revospirone (Bay Vq 7813) is an azapirone drug which was patented as a veterinary tranquilizer but was never marketed.[1] It acts as a selective 5-HT1A receptor partial agonist.[2] Similarly to other azapirones such as buspirone, revospirone produces 1-(2-pyrimidinyl)piperazine (1-PP) as an active metabolite.[2] As a result, it also acts as an α2-adrenergic receptor antagonist to an extent.

Notes and References

  1. Book: Macdonald F . Dictionary of Pharmacological Agents . 13 May 2012 . 1997 . CRC Press . 978-0-412-46630-4 . 1744.
  2. Löscher W, Witte U, Fredow G, Traber J, Glaser T . The behavioural responses to 8-OH-DPAT, ipsapirone and the novel 5-HT1A receptor agonist Bay Vq 7813 in the pig . Naunyn-Schmiedeberg's Archives of Pharmacology . 342 . 3 . 271–7 . September 1990 . 2149168 . 10.1007/bf00169437. 24769939 .

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