Reversine Explained

Reversine, or 2-(4-morpholinoanilino)-6-cyclohexylaminopurine, is a small molecule developed by the group of Peter G. Schultz, used for stem cell dedifferentiation.^{[1] [2]}

It also has the potential to selectively induce cell death in cancer cells.^[3]

Reversine is known to act as an antagonist of the adenosine A₃ receptor. Reversine is a potent inhibitor of the mitotic kinase Mps1^[4] and it is widely used to study the process of chromosome segregation.

External links

• Henry . Celia . January 5, 2004 . Cellular U-Turn . Chemical and Engineering News . 82 . 1 . 9 . 10.1021/cen-v082n001.p009.

Notes and References

1. Chen . Shuibing . Zhang . Qisheng . Wu . Xu . Schultz . Peter G. . Ding . Sheng . Dedifferentiation of Lineage-Committed Cells by a Small Molecule . Journal of the American Chemical Society . 126 . 2 . 410–1 . 2004 . 14719906 . 10.1021/ja037390k .
2. Chen . S. . Takanashi . S. . Zhang . Q. . Xiong . W. . Zhu . S. . Peters . E. C. . Ding . S. . Schultz . P. G. . Reversine increases the plasticity of lineage-committed mammalian cells . Proceedings of the National Academy of Sciences . 104 . 25 . 10482–7 . 2007 . 17566101 . 1965539 . 10.1073/pnas.0704360104 . 2007PNAS..10410482C . free .
3. Piccoli . Marco . Palazzolo . Giacomo . Conforti . Erika . Lamorte . Giuseppe . Papini . Nadia . Creo . Pasquale . Fania . Chiara . Scaringi . Raffaella . Bergante . Sonia . Tringali . Cristina . Roncoroni . Leda . Mazzoleni . Stefania . Doneda . Luisa . Galli . Rossella . Venerando . Bruno . Tettamanti . Guido . Gelfi . Cecilia . Anastasia . Luigi . The synthetic purine reversine selectively induces cell death of cancer cells . Journal of Cellular Biochemistry . 113 . 10 . 3207–17 . 2012 . 22615034 . 10.1002/jcb.24197 . 2741461 . free .
4. Santaguida. Stefano. Tighe. Anthony. D'Alise. Anna Morena. Taylor. Stephen S.. Musacchio. Andrea. 2010-07-12. Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine. The Journal of Cell Biology. 190. 1. 73–87. 10.1083/jcb.201001036. 1540-8140. 2911657. 20624901.