Reuben Sanford (December 3, 1780 Woodbury, Connecticut - May 19, 1855 Columbus, Ohio) was an American politician from New York.
He was the son of Oliver Sanford (1744–1817) and Phebe (Newton) Sanford (1748–1793). About 1800, he removed to that part of Jay, New York which was separated in 1821 as the Town of Dansville, and renamed Wilmington in 1822. On February 16, 1804, he married Polly Lewis (1784–1869), and they had seven children. He was a major of an independent battalion drawn from Essex County, New York, Sanford's Battalion, which was set off from the New York State 9th Regiment of Infantry during the War of 1812. He and his men fought in the Battle of Plattsburgh in September, 1814.
He was a member of the New York State Assembly (Essex Co.) in 1814-15, 1816 and 1816-17. He was a delegate to the New York State Constitutional Convention of 1821. He was Postmaster of Wilmington from before 1830 until 1842. He was a member of the New York State Senate (4th D.) from 1828 to 1831, sitting in the 51st, 52nd, 53rd and 54th New York State Legislatures.
He was buried at the Green Lawn Cemetery, Columbus, Ohio.