Retinoic acid-inducible orphan G protein-coupled receptor explained

G protein-coupled receptor, family C, group 5, member A
Hgncid:	9836
Symbol:	GPRC5A
Altsymbols:	RAIG1, RAI3
Entrezgene:	9052
Omim:	604138
Refseq:	NM_003979
Uniprot:	Q8NFJ5
Chromosome:	12
Arm:	p
Band:	13
Locussupplementarydata:	-p12.3

G protein coupled receptor, family C, group 5, member B
Hgncid:	13308
Symbol:	GPRC5B
Altsymbols:	RAIG2
Entrezgene:	51704
Omim:	605948
Refseq:	NM_016235
Uniprot:	Q9NZH0
Chromosome:	16
Arm:	p
Band:	12

G protein-coupled receptor, family C, group 5, member C
Hgncid:	13309
Symbol:	GPRC5C
Altsymbols:	RAIG3
Entrezgene:	55890
Omim:	605949
Refseq:	NM_022036
Uniprot:	Q9NQ84
Chromosome:	17
Arm:	q
Band:	25

G protein-coupled receptor, family C, group 5, member D
Hgncid:	13310
Symbol:	GPRC5D
Entrezgene:	55507
Omim:	607437
Refseq:	NM_018654
Uniprot:	Q9NZD1
Chromosome:	12
Arm:	p
Band:	13.3

The Retinoic Acid-Inducible orphan G-protein-coupled receptors (RAIG) are a group of four closely related G protein-coupled receptors whose expression is induced by retinoic acid.^{[1] [2] [3] [4]}

The exact function of these proteins has not been determined but they may provide a mechanism by which retinoic acid can influence G protein signal transduction cascades. In addition, RAIG receptors interact with members of the frizzled class of G protein-coupled receptors and appear to activate the Wnt signaling pathway.^[5]

External links

• Web site: GPRC5 (RAIG) Receptors . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2007-10-25 . 2016-03-03 . https://web.archive.org/web/20160303183243/http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1323 . dead .

Notes and References

1. Cheng Y, Lotan R . Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor . J. Biol. Chem. . 273 . 52 . 35008–15 . 1998 . 9857033 . 10.1074/jbc.273.52.35008 . free .
2. Bräuner-Osborne H, Krogsgaard-Larsen P . Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain . Genomics . 65 . 2 . 121–8 . 2000 . 10783259 . 10.1006/geno.2000.6164 .
3. Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN . Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C) . Genomics . 67 . 1 . 8–18 . 2000 . 10945465 . 10.1006/geno.2000.6226 .
4. Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P . Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D . Biochim. Biophys. Acta . 1518 . 3 . 237–48 . 2001 . 11311935 . 10.1016/s0167-4781(01)00197-x.
5. Harada Y, Yokota C, Habas R, Slusarski DC, He X . Retinoic Acid-Inducible G Protein-Coupled Receptors Bind to Frizzled Receptors and May Activate Non-canonical Wnt Signaling . Biochem. Biophys. Res. Commun. . 358 . 4 . 968–75 . 2007 . 17521608 . 10.1016/j.bbrc.2007.04.208. 2854581 .