Reticulocalbin 2 Explained
Reticulocalbin-2 is a protein that in humans is encoded by the RCN2 gene.[1] [2] [3]
Reticulocalbin 2 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. The RCN2 gene maps to the same region as type 4 Bardet-Biedl syndrome (MIM:600374), suggesting a possible causative role for reticulocalbin 2 in the disorder.[3]
Further reading
- Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
- Bouwmeester T, Bauch A, Ruffner H, etal . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . 11683986 .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Kirkpatrick LL, Matzuk MM, Dodds DC, Perin MS . Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2 . J. Biol. Chem. . 275 . 23 . 17786–92 . 2000 . 10748068 . 10.1074/jbc.M002254200 . free .
- Dodds DC, Omeis IA, Cushman SJ, etal . Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49 . J. Biol. Chem. . 272 . 34 . 21488–94 . 1997 . 9261167 . 10.1074/jbc.272.34.21488 . free .
- Weis K, Griffiths G, Lamond AI . The endoplasmic reticulum calcium-binding protein of 55 kDa is a novel EF-hand protein retained in the endoplasmic reticulum by a carboxyl-terminal His-Asp-Glu-Leu motif . J. Biol. Chem. . 269 . 29 . 19142–50 . 1994 . 10.1016/S0021-9258(17)32286-X . 8034671 . free .
Notes and References
- Wang JY, Zhen DK, Bianchi DW, Androphy EJ, Chen JJ . Assignment of the gene for ERC-55 (RCN2) to human chromosome band 15q22.33→q24.1 by in situ hybridization . Cytogenet Cell Genet . 79 . 1–2 . 60–1 . Apr 1998 . 9533013 . 10.1159/000134683 .
- Chen JJ, Reid CE, Band V, Androphy EJ . Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein . Science . 269 . 5223 . 529–31 . Aug 1995 . 7624774 . 10.1126/science.7624774 . 1995Sci...269..529C .
- Web site: Entrez Gene: RCN2 reticulocalbin 2, EF-hand calcium binding domain.
