Reticulocalbin 1 Explained

Reticulocalbin-1 is a protein that in humans is encoded by the RCN1 gene.^{[1] [2] [3]}

Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding.

Further reading

• Lim J, Hao T, Shaw C, etal . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .
• Taylor TD, Noguchi H, Totoki Y, etal . Human chromosome 11 DNA sequence and analysis including novel gene identification . Nature . 440 . 7083 . 497–500 . 2006 . 16554811 . 10.1038/nature04632 . 2006Natur.440..497T . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ozawa M, Muramatsu T . Reticulocalbin, a novel endoplasmic reticulum resident Ca(2+)-binding protein with multiple EF-hand motifs and a carboxyl-terminal HDEL sequence . J. Biol. Chem. . 268 . 1 . 699–705 . 1993 . 10.1016/S0021-9258(18)54208-3 . 8416973 . free .

Notes and References

1. Kent J, Lee M, Schedl A, Boyle S, Fantes J, Powell M, Rushmere N, Abbott C, van Heyningen V, Bickmore WA . The reticulocalbin gene maps to the WAGR region in human and to the Small eye Harwell deletion in mouse . Genomics . 42 . 2 . 260–7 . Sep 1997 . 9192846 . 10.1006/geno.1997.4706 .
2. Ozawa M . Cloning of a human homologue of mouse reticulocalbin reveals conservation of structural domains in the novel endoplasmic reticulum resident Ca(2+)-binding protein with multiple EF-hand motifs . J Biochem . 117 . 5 . 1113–9 . Mar 1996 . 8586628 . 10.1093/oxfordjournals.jbchem.a124815.
3. Web site: Entrez Gene: RCN1 reticulocalbin 1, EF-hand calcium binding domain.