Reticuline oxidase explained
| reticuline oxidase |
| Ec Number: | 1.21.3.3 |
| Cas Number: | 152232-28-5 |
| Go Code: | 0050468 |
In enzymology, a reticuline oxidase is an enzyme that catalyzes the chemical reaction
(S)-reticuline + O2
(S)-scoulerine + H
2O
2Thus, the two substrates of this enzyme are (S)-reticuline and O2, whereas its two products are (S)-scoulerine and H2O2.
This enzyme belongs to the family of oxidoreductases, specifically those acting on X-H and Y-H to form an X-Y bond with oxygen as acceptor. The systematic name of this enzyme class is (S)-reticuline:oxygen oxidoreductase (methylene-bridge-forming). Other names in common use include BBE, berberine bridge enzyme, berberine-bridge-forming enzyme, and tetrahydroprotoberberine synthase. This enzyme participates in alkaloid biosynthesis i.
References
- Steffens P, Nagakura N, Zenk MH . 1984 . The berberine bridge forming enzyme in tetrahydroprotoberberine biosynthesis . Tetrahedron Lett. . 25 . 9 . 951 - 952 . 10.1016/S0040-4039(01)80070-8 .
- Dittrich H, Kutchan TM . 1991 . Molecular cloning, expression, and induction of berberine bridge enzyme, an enzyme essential to the formation of benzophenanthridine alkaloids in the response of plants to pathogenic attack . Proc. Natl. Acad. Sci. U.S.A. . 88 . 9969 - 73 . 1946465 . 10.1073/pnas.88.22.9969 . 22 . 52848 . free .
- Kutchan TM, Dittrich H . 1995 . Characterization and mechanism of the berberine bridge enzyme, a covalently flavinylated oxidase of benzophenanthridine alkaloid biosynthesis in plants . J. Biol. Chem. . 270 . 24475 - 81 . 7592663 . 10.1074/jbc.270.41.24475 . 41 . free .
