Reticular pigmented anomaly of the flexures explained

Reticular pigmented anomaly of the flexures
Synonyms:	Kitamura reticulate acropigmentation^[1]
Field:	dermatology

Reticular pigmented anomaly of the flexures (also known as dark dot disease and Dowling–Degos disease) is a fibrous anomaly of the flexures or bending parts of the axillae, neck and inframammary/sternal areas.^[2] It is an autosomal-dominant pigmentary disorder that may appear in adolescence or adulthood. This condition is due to mutations in structural/desmosomal proteins found within stratified squamous epithelium.^[3]

Dark dot disease is associated with KRT5.^[4]

See also

• List of cutaneous conditions
• List of cutaneous conditions caused by mutations in keratins
• Skin lesion

Notes and References

1. Web site: Dowling-Degos disease Genetic and Rare Diseases Information Center (GARD) – an NCATS Program . rarediseases.info.nih.gov . 23 April 2019.
2. James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. .
3. Book: Rapini, Ronald P. . Bolognia, Jean L. . Jorizzo, Joseph L. . Dermatology: 2-Volume Set . Mosby . St. Louis . 2007 . 978-1-4160-2999-1 .
4. Betz RC, Planko L, Eigelshoven S, etal . Loss-of-function mutations in the keratin 5 gene lead to Dowling-Degos disease . Am. J. Hum. Genet. . 78 . 3 . 510–9 . March 2006 . 16465624 . 1380294 . 10.1086/500850 .