Respiratory syncytial virus G protein explained

Major surface glycoprotein G
Symbol:	G
Organism:	Human respiratory syncytial virus A (strain A2)
Uniprot:	P03423
Pdb:	5WN9

Respiratory syncytial virus G protein is a glycoprotein produced by respiratory syncytial virus.^{[1] [2] [3]} Some features of the G protein suggest it could be important to respiratory syncytial virus vaccine or antiviral drug target design. ^{[4] [5]}

Further reading

• Book: McLellan JS, Ray WC, Peeples ME . Structure and Function of Respiratory Syncytial Virus Surface Glycoproteins . Current Topics in Microbiology and Immunology . Challenges and Opportunities for Respiratory Syncytial Virus Vaccines . 372 . 83–104 . 2013 . 24362685 . 4211642 . 10.1007/978-3-642-38919-1_4 . 978-3-642-38918-4 .

Notes and References

1. Harcourt J, Alvarez R, Jones LP, Henderson C, Anderson LJ, Tripp RA . Respiratory syncytial virus G protein and G protein CX3C motif adversely affect CX3CR1+ T cell responses . Journal of Immunology . 176 . 3 . 1600–8 . February 2006 . 16424189 . 10.4049/jimmunol.176.3.1600 . free .
2. Li XQ, Fu ZF, Alvarez R, Henderson C, Tripp RA . Respiratory syncytial virus (RSV) infects neuronal cells and processes that innervate the lung by a process involving RSV G protein . Journal of Virology . 80 . 1 . 537–40 . January 2006 . 16352577 . 1317531 . 10.1128/JVI.80.1.537-540.2006 .
3. Zlateva KT, Lemey P, Moës E, Vandamme AM, Van Ranst M . Genetic variability and molecular evolution of the human respiratory syncytial virus subgroup B attachment G protein . Journal of Virology . 79 . 14 . 9157–67 . July 2005 . 15994810 . 1168771 . 10.1128/JVI.79.14.9157-9167.2005 .
4. Li X, Sambhara S, Li CX, Ettorre L, Switzer I, Cates G, James O, Parrington M, Oomen R, Du RP, Klein M . Plasmid DNA encoding the respiratory syncytial virus G protein is a promising vaccine candidate . Virology . 269 . 1 . 54–65 . March 2000 . 10725198 . 10.1006/viro.2000.0186 . free .
5. Anderson LJ, Jadhao SJ, Paden CR, Tong S . Functional Features of the Respiratory Syncytial Virus G Protein . Viruses . 13 . 7 . July 2021 . 1214 . 34372490 . 8310105 . 10.3390/v13071214 . free .