David Gorski Explained

David Gorski
Birth Name:David Henry Gorski
Nationality:American
Doctoral Advisor:Kenneth Walsh
Field:Surgical oncology

David Henry Gorski is an American surgical oncologist and professor of surgery at Wayne State University School of Medicine.[1] He specializes in breast cancer surgery at the Karmanos Cancer Institute.[2] Gorski is an outspoken skeptic and critic of alternative medicine and the anti-vaccination movement. He writes as Orac at Respectful Insolence and as himself at Science-Based Medicine, where he is the managing editor.[3] [4] [5]

Early life and education

Gorski attended a Roman Catholic high school.[6] He went on to study medicine at the University of Michigan, earning an MD in 1988.[7] He entered a residency in general surgery in 1989 at the University Hospitals of Cleveland. Gorski completed a PhD in cellular physiology at Case Western Reserve University in 1994. His dissertation was entitled "Homeobox Gene Expression and Regulation in Vascular Myocytes."[8] Gorski continued his residency (1993–96) and completed a surgical oncology research fellowship (1996–99) at The University of Chicago.[9]

Prior to 2005, he was active on the early internet message boards of Usenet participating in flame wars.

Career

In the mid 2000s, Gorski taught surgery as an associate professor at the Rutgers Cancer Institute of New Jersey[10] and the Robert Wood Johnson Medical School, at Rutgers University.[11]

In 2007 he received the Advanced Clinical Research Award in Breast Cancer from the American Society of Clinical Oncology.[12] He was awarded research grants by The Breast Cancer Research Foundation in 2008, 2009, and 2010.

In 2008, Gorski joined the Wayne State University School of Medicine[13] and became affiliated with the Karmanos Cancer Institute. He is a professor of surgery and oncology at the Wayne State University School of Medicine,[14] whose laboratory conducts research on transcriptional regulation of vascular endothelial cell phenotype, as well as the role of metabotropic glutamate receptors in breast cancer. In 2009, he was appointed the cancer liaison physician for the American College of Surgeons Committee on Cancer.[15]

He became the co-director of the Michigan Breast Oncology Quality Initiative in 2013.[16] [17]

Gorski is listed as a founder of the Institute for Science in Medicine[18] and as a member of the American Society of Clinical Oncology.[19]

Research

Gorski's 1999 article "Blockade of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation", characterizing the effects of angiogenesis inhibitors on the effectiveness of anti-tumor therapies, has been cited over 900 times according to PubMed.[20] This research has been used in anti-tumor therapeutic research, including an observation that angiogenesis inhibitors enhanced the therapeutic effects of ionizing radiation "by preventing repair of radiation damage to endothelial cells,"[21] and in determining the potential of combinational therapies to allow reduction of the dosages in toxic conventional treatments[22] while sustaining tumor regression when combined with specific antibodies and radiation therapy.[23]

Gorski's work with Helena Mauceri and others, published in Nature in 1998 as "Combined effects of angiostatin and ionizing radiation in antitumour therapy" studied the "combined effects of angiostatin" (a protein occurring in several animal species) "and ionizing radiation in anti-tumor therapy"[24] led to investigation into the selective destruction of tumor cells, which according to a 1999 study by Gregg L. Semenza (citing Mauceri and others), "are more hypoxic than normal cells," allowing for "tumor cells to be killed without major systemic side effects."[25]

In 2008, Gorski and Yun Chen published an article titled "Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5" that investigated the use of microRNA to regulate angiogenesis.[26]

Skepticism of alternative medicine

Gorski is a vocal skeptic of alternative medicine, known to confront pseudoscience.[27]

He has criticized the prevalence of pseudoscience in the medical field including the use of alternative therapies,[28] acupuncture, detoxification,[29] and the use of dietary treatment to manage autism.

Blogs

Gorski is a prolific blogger. In 2004, he began writing a blog entitled Respectful Insolence at Blogspot under the pen name Orac. Respectful Insolence was then moved to the ScienceBlogs website.[30] [31] Alissa Quart, writing for Columbia Journalism Review in 2010, described Orac as a "self-appointed autism expert" known for attacking the "vaccines-cause-autism set" and who had recently celebrated when an opponent lost their medical license.[32] In 2015, writing for Slate, Jacob Brogan said Orac was a "doctor who blogs about skepticism and medicine".[33]

In 2008 Gorski started blogging at Science-Based Medicine under his real name while continuing to blog as Orac at Respectful Insolence.[34] [35] He was later doxed as Orac. As the managing editor at Science-Based Medicine, Gorski has posted on issues of medicine and pseudoscience, including the anti-vaccination movement, alternative therapies, and cancer research and treatment. In 2010, Gorski recounted how members of the anti-vaccine blog Age of Autism wrote to the board of directors at Wayne State University and asked that he be prevented from blogging.[36]

Writing for The Atlantic in 2011, David H. Freedman described Gorski as one of the more "prickly anti-alternative-medicine warriors"[37] and said he was "among a small, loud band of alt-med critics."[38]

Gorski contributed to the James Randi Education Foundation's series of EBooks: Science Based Medicine Guides.[39] He is a fellow of the Committee for Skeptical Inquiry.[40] He was a speaker at The Amaz!ng Meeting in 2009, 2010, 2012 and 2013[41] [42] and has been a participant on several panels on alternative medicine.[43] [44] [45] He called attention to a 2005 paper by John Ioannidis on problems with published research.[46]

Gorski has advocated for open research data of clinical trial results and for only using evidence-based medicine to treat disease. He has been critical of Senator Tom Harkin's support of the National Center for Complementary and Alternative Medicine (NCCAM), which became the National Center for Complementary and Integrative Health.[47] He has criticized the National Institutes of Health (NIH) and NCCAM for funding and publishing research on unproven therapies not supported by science-based evidence,[48] [49] and has commented on medical ethics and methods of alternative medicine.[50]

Gorski has criticized popularization of pseudoscience by the media and celebrities such as Oprah Winfrey,[51] Bill Maher, Ann Coulter, and The Huffington Post. In June 2013, he expressed support for healthcare professionals speaking out against poor medical practices and the sale of unproven treatments. Gorski was interviewed by WPRR in 2012.[52] He criticized the American Medical Student Association for their co-sponsorship of an Integrative Medicine Day.[53]

In September 2014, Gorski and fellow skeptic Steven Novella published an article in Trends in Molecular Medicine denouncing the study of integrative medicine as harmful to science.[54] [55] The following month Gorski also published an article critical of integrative oncology.[56] Six of his colleagues responded to express concerns with his view on integrative oncology.[57]

Personal life

Gorski is married. His views have gradually shifted from conservative to center-left Democrat.

Publications

External links

Notes and References

  1. Web site: David Gorski . 25 October 2019 . Wayne State University – School of Medicine – Cancer Biology Program . 9 August 2021 . en.
  2. Web site: . David Gorski M.D., Ph.D. . Physician Details . 9 August 2021 . 2013.
  3. News: Szabo. Lisa. How to guard against a quack. 22 June 2013. USA Today. . 18 June 2013.
  4. Web site: David H. Gorski, MD, PhD – Managing Editor. Science-Based Medicine. 5 October 2008 . 10 June 2013.
  5. Web site: Respectful Insolence. 2021-07-09. RESPECTFUL INSOLENCE. en-US.
  6. Hongoltz-Hetling . Matthew . 2023-02-28 . A Doctor's War Against the Right-Wing Medical-Freedom Movement . The New Republic . 2023-04-09 . 0028-6583.
  7. Web site: 2019-10-25 . David Gorski . 2023-04-09 . Cancer Biology Program . en.
  8. Book: Gorski, D.. Homeobox gene expression and regulation in vascular myocytes. 1994. Case Western Reserve University. 31923610.
  9. Web site: David Gorski, M.D.. 2005. Faculty. Department of Surgery / Detroit Medical Center, Wayne State University. https://web.archive.org/web/20130125033701/http://www.med.wayne.edu/surgery/faculty/DGorski.html. 25 January 2013. dead. 20 March 2013.
  10. Web site: 2005 . Graduate School-New Brunswick 2005-2007 Programs, Faculty, and Courses Cell and Developmental Biology 148 . 2023-04-09 . catalogs.rutgers.edu.
  11. Bepler . Gerold . Gerold Bepler . Barbara Ann Karmanos Cancer Center names Dr. David Gorski leader of breast multidisciplinary team . 1 February 2011 . . 18 June 2013 .
  12. 11 June 2007 . 14 June 2013 . Michele . Fisher . New Jersey surgical oncologist receives prestigious award at international conference . . CINJ scientist receives a near half-million dollars for future breast cancer research. . https://web.archive.org/web/20130205153112/http://www.umdnj.edu/about/news_events/releases/07/r061107_NJ_SurgicalOncologist_ReceivesPrestigiousAward_atInternationalConference.htm . 5 February 2013. Cancer Institute of New Jersey .
  13. Web site: September 29, 2021 . Meet the provider: David Gorski, M.D. . 2023-04-10 . www.waynehealthcares.org.
  14. Web site: Cancer Biology Graduate Program . David H. Gorski . . 2013 . 14 June 2013 . https://web.archive.org/web/20120722100844/http://cancerbiologyprogram.med.wayne.edu/faculty/gorski.php . 22 July 2012 . dead .
  15. Web site: Dr. David Gorski appointed Cancer Liaison Physician for Karmanos. 7 January 2009. Prognosis E-News. Wayne State University School of Medicine. https://web.archive.org/web/20170801083903/https://www.med.wayne.edu/news/2009/01/07/dr-david-gorski-appointed-cancer-liaison-physician-for-karmanos/. August 1, 2017. live. May 17, 2013.
  16. Web site: Breast Cancer Program. 2013. Barbara Ann Kamanos Cancer Institute, Wayne State University. 17 May 2013 . dead . https://web.archive.org/web/20190108030724/https://www.karmanos.org/cancer-care/teams/Breast-Team . 8 January 2019.
  17. Web site: Karmanos Cancer Center's Dr. David Gorski appointed program co-director of Michigan Breast Oncology Quality Initiative. July 30, 2013. Karmanos Cancer Institute. https://web.archive.org/web/20170801084315/https://www.med.wayne.edu/news/2013/07/30/dr-gorski-named-co-director-of-michigan-breast-oncology-quality-initiative/. August 1, 2017. live. August 2, 2013.
  18. Web site: ISM Fellows . David H. Gorski, MD, PhD . 2011 . Institute for Science in Medicine . 13 June 2013.
  19. News: Pink Press . . 8 . 2007–2008 Grantees . https://web.archive.org/web/20120807020004/http://www.bcrfcure.org/pdf/newsletter_winter08.pdf . 2012-08-07 . Winter 2008 . 2013-06-26 . dead . Alt URLNews: Pink Press . The Breast Cancer Research Foundation . 9 . 2008–2009 Grantees . https://web.archive.org/web/20120807020418/http://www.bcrfcure.org/pdf/newsletter_winter09.pdf . 2012-08-07 . Winter 2009 . 2013-06-26 . dead . Alt URLNews: Pink Press . The Breast Cancer Research Foundation . 8 . 2009–2010 Grantees . https://web.archive.org/web/20120807015558/http://www.bcrfcure.org/pdf/newsletter_winter10.pdf . 2012-08-07 . Winter 2010 . 2013-06-26 . dead . Alt URL
  20. . 59 . 14 . 3374–3378 . Gorski . David H. . Beckett . Michael A. . Nora T. . Jaskowiak . Douglas P. . Calvin . Helena J. . Mauceri . Rabih M. . Salloum . Saraswathy . Seetharam . Ann . Koons . Danielle M. . Hari . Donald W. . Kufe . Ralph R. . Weichselbaum . 4. Blockade of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation. Cancer Research . 21 June 2013. 15 July 1999 . 10416597 . .
  21. 10.1038/nrc905 . . 2 . 10 . 727–739 . Kerbel . Robert . Judah . Folkman . Judah Folkman . Clinical translation of angiogenesis inhibitors . . October 2002 . 12360276 . . 14513505 .
  22. 10.1200/JCO.2002.10.088 . . 20 . 21 . 4368–4380 . Dvorak . Harold F. . Vascular Permeability Factor/Vascular Endothelial Growth Factor: A Critical Cytokine in Tumor Angiogenesis and a Potential Target for Diagnosis and Therapy . . 1 November 2002 . . 12409337.
  23. . 105 . 8 . R15–R24 . Klement . Giannoula . Sylvain . Baruchel . Janusz . Rak . Shan . Man . Katherine . Clark . Daniel J. . Hicklin . Peter . Bohlen . Robert S. . Kerbel . 4. Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity . . . 15 April 2000 . 10772661. 10.1172/JCI8829. 517491.
  24. Mauceri . Helena J. . Hanna . Nader N. . Beckett . Michael A. . Gorski . David H. . Staba . Mary-Jane . Stellato . Kerri Anne . Bigelow . Kevin . Heiman . Ruth . Gately . Stephen . Dhanabal . Mohanraj . Soff . Gerald A. . Sukhatme . Vikas P. . Kufe . Donald W. . Weichselbaum . Ralph R. . 4. Combined effects of angiostatin and ionizing radiation in antitumour therapy . . 394 . 16 July 1998 . 287–291 . 10.1038/28412 . 9685160 . . . 6690. 1998Natur.394..287M . 4391890 .
  25. Semenza . Gregg L. . 1999 . Regulation of Mammalian O2 Homeostasis by Hypoxia-Inducible Factor 1 . . . 15 . 1 . 551–578 . 10.1146/annurev.cellbio.15.1.551 . . 10611972.
  26. 10.1182/blood-2007-07-104133 . . 111 . 3 . 1217–1226 . Chen . Yun . David H. . Gorski . Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5 . . . 1 February 2008 . . 2214763.
  27. Web site: Hiltzik . Michael . 2015-04-20 . A physicians' attack on Dr. Oz explodes into a new controversy . 2023-04-09 . Los Angeles Times . en-US.
  28. News: . Munger . Dave . Controls for acupuncture studies are improving. Their results are not. How are peer reviewers reacting? . 2 September 2009 . . . 27 June 2013 . https://web.archive.org/web/20180914203543/http://seedmagazine.com/content/article/acupuncture_real_or_sham/ . 14 September 2018 . unfit .
  29. News: Bridal Hunger Games: Losing Weight in Time for the Wedding . Lee . Linda . . 13 April 2012 . 25 June 2013.
  30. Web site: Bremner . Doug. Doug Bremner. Blogging doctors rock on! . The Huffington Post . 19 September 2008 . 24 June 2013 .
  31. Web site: Respectful Insolence . Gorski . David . ScienceBlogs . 20 June 2013 . https://web.archive.org/web/20130624051121/http://scienceblogs.com/insolence/author/oracknows/ . 24 June 2013 . dead .
  32. Web site: Quart . Alissa . July 2010 . The Trouble with Experts . 2023-04-09 . Columbia Journalism Review . en.
  33. News: Brogan . Jacob . 2015-12-07 . Depression Is Real. "Hypersensitivity to Wi-Fi" Isn't. . en-US . Slate . 2023-04-09 . 1091-2339.
  34. Web site: Who is Orac? . Respectful Insolence . 31 July 2018.
  35. Book: Beall . Jeffrey . Kaufman . Allison B. . Kaufman . James C . Pseudoscience: The Conspiracy Against Science . 2018 . MIT Press . 978-0262344821 . https://books.google.com/books?id=iQFKDwAAQBAJ&pg=PA296 . en . Chapter 12: Scientific Soundness and the Problem of Predatory Journals.
  36. Web site: The price of opposing medical pseudoscience . Science-Based Medicine . 18 June 2010 . 14 June 2013 . Gorski . David H..
  37. News: Freedman . David H. . Doctors who care: Does alternative medicine work? . . May–June 2012 . 24 June 2013 . . .
  38. Web site: Freedman . David H. . 2011-06-23 . What's Eating the Small, Loud Band of Alt-Med Critics? . 2023-04-09 . The Atlantic . en.
  39. Web site: JREF publishes three volumes on science-based medicine . . 28 June 2013.
    Web site: . JREF publishes three more science-based medicine volumes . James Randi Education Foundation . 28 June 2013 .
    Web site: . Science-based medicine Ebooks, volumes 7-12 now available . James Randi Education Foundation . 28 June 2013.
  40. Web site: CSI Fellows and Staff . 2009 . Committee for Skeptical Inquiry . 2 August 2013 .
  41. Web site: The Amaz!ing Meeting 2013: Schedule . The Amza!ing Meeting website . 2013 . 24 June 2013 . James Randi Education Foundation . 27 June 2013 . https://web.archive.org/web/20130627051415/http://www.amazingmeeting.com/tam2013/schedule/ . dead .
  42. Web site: Novella . Steven . Steven Novella . Science-Based Medicine Conference . Neurologica blog . . 6 March 2009 . 24 June 2013.
    Wagg . Jeffrey . The Amaz!ng Meeting 8, 2010 Schedule . . 2010 . 24 June 2013 .
    Expert panel trashes "alternative medicine" concept . Consumer Health Digest . 12–29 . 23 August 2012 . . 25 June 2013 .
    Web site: The Amaz!ing Meeting 2012: Program . The Amaz!ng Meeting website . 2012 . James Randi Education Foundation . 24 June 2013.
  43. Web site: Drs. Ben Goldacre, David Gorski and Michael Shermer on the threat of pseudoscience . 18 October 2010 . . 20 June 2013.
  44. Web site: David Gorski — NECSS . Northeast Conference on Science and Skepticism website (NECSS) . New England Skeptical Society and NYC Skeptics . 24 June 2013 . 6 June 2013 . https://web.archive.org/web/20130606065249/http://necss.org/speakers/david-gorski/ . dead .
  45. Web site: Speakers . CSICon 2012 website . . 2012 . 24 June 2013 . https://web.archive.org/web/20130902062840/http://csiconference.org/speakers.php . 2 September 2013 . dead .
  46. Book: Roach . Mary . The Best American Science and Nature Writing 2011 . Folger . Tim . Houghton Mifflin Harcourt . 2011 . 978-0-547-67846-7 . 123–124 . Mary Roach . Tim Folger . 21 June 2013.
  47. Book: Specter, Michael . Denialism: How Irrational Thinking Harms the Planet and Threatens Our Lives . 21 June 2013 . 2009 . Penguin Group US . 978-1-101-15102-0.
  48. Systematic reviews of animal models: Methodology versus epistemology . Greek . Ray . Menache . Andre . . . 2013 . 10 . 3 . 206–221 . 10.7150/ijms.5529 . 23372426 . . 3558708.

  49. Book: Berezow . Alex B. . Campbell . Hank . Science Left Behind: Feel-Good Fallacies and the Rise of the Anti-Scientific Left. registration . 2013-06-21 . 2012 . PublicAffairs . 978-1-61039-165-8.
    Book: Kay, Alison J. . What If There's Nothing Wrong? . 21 June 2013 . 2012 . Balboa Press . 978-1-4525-6147-9 . 283.



  51. News: Gorski . David . Is Oprah Winfrey giving us bad medicine? . . 7 June 2009 . 21 June 2013 . .
    News: Amarasingam . Amarnath . Oprah: High priestess of the New Age . . 25 May 2011 . . 21 June 2013 . 11 January 2012 . https://web.archive.org/web/20120111102010/http://www.washingtonpost.com/blogs/on-faith/post/oprah-high-priestess-of-the-new-age/2011/05/25/AGJOBHBH_blog.html . dead .
  52. Dr. David Gorski and Mike Farrell . 14 August 2012 . 16 June 2013 . Brayton . Ed (host) . Culture Wars Radio . WPRR, Public Reality Radio . podcast . https://web.archive.org/web/20121113211638/http://www.publicrealityradio.org/programs/culturewarsradio/episodes/8-14-2012-dr-david-gorski-and- . 13 November 2012.
  53. Web site: Gorski . David . 2012-10-22 . The American Medical Student Association: On "integrating" quackery with science-based medicine . 2022-12-29 . sciencebasedmedicine.org . en-US.
  54. Gorski. David H.. Novella. Steven P.. Clinical trials of integrative medicine: testing whether magic works?. Trends in Molecular Medicine. 10.1016/j.molmed.2014.06.007. 25150944. 20. 9. Sep 2014. 473–6.
  55. Web site: US doctors spark homeopathy row . https://web.archive.org/web/20140823170355/http://www.telegraphindia.com/1140821/jsp/nation/story_18743298.jsp#.U_d9XrxdXN4 . dead . August 23, 2014 . . 20 August 2014 . 22 August 2014 . Mudur, GS.
  56. Gorski . David H. . October 2014 . Integrative oncology: really the best of both worlds? . Nature Reviews Cancer . en . 14 . 10 . 692–700 . 10.1038/nrc3822 . 25230880 . 33539406 . 1474-1768.
  57. Greenlee . Heather . Zick . Suzanna M. . Rosenthal . David . Cohen . Lorenzo . Cassileth . Barrie . Tripathy . Debu . March 2015 . Integrative oncology — strong science is needed for better patient care . Nature Reviews Cancer . en . 15 . 3 . 165 . 10.1038/nrc3822-c1 . 25693833 . 8053861 . 1474-1768. free .
  58. Bigliardi . Stefano . The Advocates of Pseudoscience Are Not Monsters – but Pseudoscience Is . Skeptical Inquirer . 2019 . 43 . 6 . 58–59 . Center for Inquiry.

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