| Sado Estuary Nature Reserve | |
| Iucn Category: | IV |
| Iucn Ref: | [1] |
| Map: | Portugal |
| Location: | Setúbal District |
| Nearest City: | Setúbal |
| Coordinates: | 38.4556°N -8.7583°W |
| Area Km2: | 239.71 |
| Created: | 1980 |
| Visitation Num: | 78,566 |
| Visitation Year: | 2017-2020 (average) |
| Visitation Ref: | [2] |
| Governing Body: | ICNF |
Sado Estuary Natural Reserve (Portuguese: Reserva Natural do Estuário do Sado) is a nature reserve in Portugal. It is one of the 30 areas which are officially under protection in the country. It is located between the municipalities of Alcácer do Sal, Comporta and Setúbal.