Replication error phenotype explained

The positive replication error phenotype (RER+) defines a subgroup of tumors that have been documented well in Hereditary nonpolyposis colorectal cancer (HNPCC). More recently, this phenotype also has been described in breast carcinoma and is a predictor of metastases.[1]

Notes and References

  1. Chagpar . Anees . Magliocco . Anthony . Kerviche . Annette . Tan . Leonard . Walley . Barbara . DeCoteau . John F. . The replication error phenotype is associated with the development of distant metastases in hormonally treated patients with breast carcinoma . Cancer . 1 March 2004 . 100 . 5 . 913–919 . . 10.1002/cncr.20084 . 14983485 . 25814306 .

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