Renanolone Explained

Renanolone (INN), or 11-ketopregnanolone, also known as 5β-pregnan-3α-ol-11,20-dione, is a synthetic neuroactive steroid which is described as a general anesthetic but was never introduced for clinical use.^[1] Its isomers, alfaxolone and alfadolone, are also general anesthetics, and are known to act as positive allosteric modulators of the GABA_A receptor, a property which is likely the case for renanolone as well.

Chemistry

See also: List of neurosteroids.

See also

• Alfadolone
• Alfaxolone
• Ganaxolone
• Hydroxydione
• Minaxolone
• Pregnanolone

Notes and References

1. Book: Hill RA, Makin HL, Kirk DN, Murphy GM . Dictionary of Steroids . 23 May 1991 . CRC Press . 978-0-412-27060-4 . 592.