Reldesemtiv Explained

Legal Status:

Investigational

Cas Number:

1345410-31-2

Pubchem:

67454400

Iuphar Ligand:

11801

Drugbank:

DB15256

Chemspiderid:

75531291

Unii:

4S0HBYW6QE

Kegg:

D11363

Chembl:

4297600

Synonyms:

CK-2127107

Iupac Name:

1-[2-[[3-fluoro-1-(3-fluoropyridin-2-yl)cyclobutyl]methylamino]pyrimidin-5-yl]pyrrole-3-carboxamide| C=19 | H=18 | F=2 | N=6 | O=1| SMILES = C1C(CC1(CNC2=NC=C(C=N2)N3C=CC(=C3)C(=O)N)C4=C(C=CC=N4)F)F| StdInChI = 1S/C19H18F2N6O/c20-13-6-19(7-13,16-15(21)2-1-4-23-16)11-26-18-24-8-14(9-25-18)27-5-3-12(10-27)17(22)28/h1-5,8-10,13H,6-7,11H2,(H2,22,28)(H,24,25,26)| StdInChIKey = MQXWPWOCXGARRK-UHFFFAOYSA-N}}Reldesemtiv is an investigational new drug that is being evaluated to treat amyotrophic lateral sclerosis.^[1] It is a troponin activator.^[2]

References

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Notes and References

1. Web site: Reldesemtiv - Astellas Pharma/Cytokinetics . AdisInsight . Springer Nature Switzerland AG .
2. Collibee SE, Bergnes G, Chuang C, Ashcraft L, Gardina J, Garard M, Jamison CR, Lu K, Lu PP, Muci A, Romero A, Valkevich E, Wang W, Warrington J, Yao B, Durham N, Hartman J, Marquez A, Hinken A, Schaletzky J, Xu D, Hwee DT, Morgans D, Malik FI, Morgan BP . Discovery of Reldesemtiv, a Fast Skeletal Muscle Troponin Activator for the Treatment of Impaired Muscle Function . Journal of Medicinal Chemistry . 64 . 20 . 14930–14941 . October 2021 . 34636234 . 10.1021/acs.jmedchem.1c01067 . free .