| relaxin/insulin-like family peptide receptor 1 | |
| Hgncid: | 19718 |
| Symbol: | RXFP1 |
| Altsymbols: | LGR7 |
| Entrezgene: | 59350 |
| Omim: | 606654 |
| Refseq: | NM_021634 |
| Uniprot: | Q9HBX9 |
| Chromosome: | 4 |
| Arm: | q |
| Band: | 31.3 |
| relaxin/insulin-like family peptide receptor 2 | |
| Hgncid: | 17318 |
| Symbol: | RXFP2 |
| Altsymbols: | LGR8, GREAT, GPR106, INSL3R |
| Entrezgene: | 122042 |
| Omim: | 606655 |
| Refseq: | NM_130806 |
| Uniprot: | Q8WXD0 |
| Chromosome: | 13 |
| Arm: | q |
| Band: | 12.3 |
| relaxin/insulin-like family peptide receptor 3 | |
| Hgncid: | 24883 |
| Symbol: | RXFP3 |
| Altsymbols: | RLN3R1, SALPR, GPCR135 |
| Entrezgene: | 51289 |
| Omim: | 609445 |
| Refseq: | NM_016568 |
| Uniprot: | Q9NSD7 |
| Chromosome: | 5 |
| Arm: | p |
| Band: | 15.1 |
| Locussupplementarydata: | -p14 |
| relaxin/insulin-like family peptide receptor 4 | |
| Hgncid: | 14666 |
| Symbol: | RXFP4 |
| Altsymbols: | GPR100, GPCR142, RLN3R2 |
| Entrezgene: | 339403 |
| Omim: | 609043 |
| Refseq: | NM_181885 |
| Uniprot: | Q8TDU9 |
| Chromosome: | 1 |
| Arm: | q |
| Band: | 22 |
The relaxin receptors are a subclass of four closely related G protein-coupled receptors (GPCR) that bind relaxin peptide hormones.[1] [2]
Below is list of human relaxin receptors, their endogenous peptide hormones, and what downstream enzymes are activated or inhibited by the receptor.
| receptor/gene | ligands | activates | inhibits | |
|---|---|---|---|---|
| relaxin 1, relaxin 2, relaxin 3 | adenylate cyclase, protein kinase A, protein kinase C, phosphatidylinositol 3-kinase, extracellular signal-regulated kinases (Erk1/2) | |||
| relaxin 1, relaxin 2, insulin-like 3 | adenylate cyclase | |||
| relaxin 3 | Erk1/2 signaling | adenylate cyclase | ||
| relaxin 3, insulin-like 3 | adenylate cyclase |