| Reg Spencer | |
| Birth Date: | 1 December 1908 |
| Birth Place: | Queensferry, Flintshire, Wales |
| Death Place: | Chester, England |
| Position: | Left half |
| Height: | 5 ft 5 in[1] |
| Years1: | 1931–1939 |
| Clubs1: | Tranmere Rovers |
| Caps1: | 235 |
| Goals1: | 3 |
Reg Spencer (1 December 1908 – 16 March 1981) was an English footballer who played as a left half for Tranmere Rovers. He made 261 appearances for Tranmere, scoring 3 goals.