| Reese Calhoun De Graffenreid | |
| Birth Date: | 7 May 1859 |
| Profession: | lawyer |
| Term Start: | March 4, 1897 |
| Term End: | August 29, 1902 |
| Party: | Democratic |
Reese Calhoun De Graffenreid (May 7, 1859 – August 29, 1902) was a U.S. Representative from Texas.
Born in Franklin, Tennessee, De Graffenreid attended the common schools of Franklin and the University of Tennessee at Knoxville. He graduated from the law department of Cumberland University, Lebanon, Tennessee. He was admitted to the bar in 1879 and commenced practice in Franklin. He moved to Chattanooga, Tennessee, where he practiced his profession for one year, and then moved to Texas. He helped in the construction of the Texas & Pacific Railroad. He resumed the practice of law at Longview, Texas in 1883.
De Graffenreid was elected county attorney and resigned two months afterward. He was an unsuccessful candidate for election in 1890 to the Fifty-second Congress.
De Graffenreid was elected as a Democrat to the Fifty-fifth, Fifty-sixth, and Fifty-seventh Congresses and served from March 4, 1897, until his death in Washington, D.C., August 29, 1902. He was interred in Greenwood Cemetery, Longview, Texas.