RCE1 explained

CAAX prenyl protease 2 is an enzyme that in humans is encoded by the RCE1 gene.^{[1] [2] [3]}

This gene encodes an integral membrane protein which is classified as a member of the metalloproteinase family. This enzyme is thought to function in the maintenance and processing of CAAX-type prenylated proteins.

Further reading

• Plummer LJ . Mutational Analysis of the Ras Converting Enzyme Reveals a Requirement for Glutamate and Histidine Residues . J. Biol. Chem. . 281 . 8 . 4596–605 . 2006 . 16361710 . 2937830 . 10.1074/jbc.M506284200 . vanc. Hildebrandt ER . Porter SB . 3 . Rogers . VA . McCracken . J . Schmidt . WK . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Bergo MO . On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy . J. Biol. Chem. . 279 . 6 . 4729–36 . 2004 . 14625273 . 10.1074/jbc.M310081200 . vanc. Lieu HD . Gavino BJ . 3 . Ambroziak . P . Otto . JC . Casey . PJ . Walker . QM . Young . SG . free .
• Maske CP . A carboxyl-terminal interaction of lamin B1 is dependent on the CAAX endoprotease Rce1 and carboxymethylation . J. Cell Biol. . 162 . 7 . 1223–32 . 2003 . 14504265 . 10.1083/jcb.200303113 . 2173957 . vanc. Hollinshead MS . Higbee NC . 3 . Bergo . MO . Young . SG . Vaux . DJ .
• Hollander IJ, Frommer E, Aulabaugh A, Mallon R . Human Ras converting enzyme endoproteolytic specificity at the P2' and P3' positions of K-Ras-derived peptides . Biochim. Biophys. Acta . 1649 . 1 . 24–9 . 2003 . 12818187 . 10.1016/s1570-9639(03)00150-x.
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Hollander I, Frommer E, Mallon R . Human ras-converting enzyme (hRCE1) endoproteolytic activity on K-ras-derived peptides . Anal. Biochem. . 286 . 1 . 129–37 . 2000 . 11038283 . 10.1006/abio.2000.4795 .

Notes and References

1. Otto JC, Kim E, Young SG, Casey PJ . Cloning and characterization of a mammalian prenyl protein-specific protease . J Biol Chem . 274 . 13 . 8379–82 . Apr 1999 . 10085068 . 10.1074/jbc.274.13.8379 . free .
2. Freije JM, Blay P, Pendas AM, Cadinanos J, Crespo P, Lopez-Otin C . Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins . Genomics . 58 . 3 . 270–80 . Jul 1999 . 10373325 . 10.1006/geno.1999.5834 .
3. Web site: Entrez Gene: RCE1 RCE1 homolog, prenyl protein peptidase (S. cerevisiae).