Razpipadon Explained

Routes Of Administration:	Oral administration
Class:	Dopamine receptor agonist
Cas Number:	1643489-35-3
Pubchem:	86764103
Chemspiderid:	58945356
Unii:	6X6XF88J2M
Chembl:	3697578
Synonyms:	CVL-871; PF-06669571; PW-0464
Iupac Name:	6-[4-[3-(difluoromethoxy)pyridin-2-yl]oxy-2-methylphenyl]-1,5-dimethylpyrimidine-2,4-dione
C:	19
H:	17
F:	2
N:	3
O:	4
Smiles:	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)OC(F)F)C3=C(C(=O)NC(=O)N3C)C
Stdinchi:	1S/C19H17F2N3O4/c1-10-9-12(27-17-14(28-18(20)21)5-4-8-22-17)6-7-13(10)15-11(2)16(25)23-19(26)24(15)3/h4-9,18H,1-3H3,(H,23,25,26)
Stdinchikey:	ZXIPVZWZRQCIRW-UHFFFAOYSA-N

Razpipadon (developmental code names CVL-871, PF-06669571, PW-0464) is a dopamine receptor agonist which is under development for the treatment of dementia-related apathy.^{[1] [2] [3] [4]} It was originated by Pfizer and is under development by Cerevel Therapeutics. Razpipadon acts as a selective partial agonist of the dopamine D₁ and D₅ receptors.^[5] It is taken via oral administration. As of April 2022, razpipadon is in phase 2 clinical trials for dementia-related apathy.

See also

• Mevidalen (LY-3154207)
• Tavapadon (CVL-751)

External links

• CVL-871 - AdisInsight
• CVL-871 - Cerevel Therapeutics

Notes and References

1. Web site: CVL 871 - AdisInsight .
2. Hatzipantelis CJ, Langiu M, Vandekolk TH, Pierce TL, Nithianantharajah J, Stewart GD, Langmead CJ . Translation-Focused Approaches to GPCR Drug Discovery for Cognitive Impairments Associated with Schizophrenia . ACS Pharmacol Transl Sci . 3 . 6 . 1042–1062 . December 2020 . 33344888 . 7737210 . 10.1021/acsptsci.0c00117 .
3. Wang HJ, Chinna-Meyyappan A, Feldman OJ, Lanctôt KL . Emerging therapies for treatment of agitation, psychosis, or apathy in Alzheimer's disease . Expert Opin Emerg Drugs . 1–15 . June 2024 . 38822731 . 10.1080/14728214.2024.2363215 .
4. Dolphin H, Dyer AH, McHale C, O'Dowd S, Kennelly SP . An Update on Apathy in Alzheimer's Disease . Geriatrics (Basel) . 8 . 4 . July 2023 . 75 . 37489323 . 10366907 . 10.3390/geriatrics8040075 . free .
5. Web site: CVL-871 - Cerevel Therapeutics . 2 January 2020 .