Ras-interacting protein 1 explained

Ras-interacting protein 1 (Rain), is a protein that in humans is encoded by the RASIP1 gene.^[1]

Function

• It is required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis.^[2]
• Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis.^{[3] [4] [5]}
• Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells.^{[6] [7]}

Clinical significance

A recent genome-wide association study (GWAS) has found that genetic variations in RASIP1 are associated with late-onset sporadic Alzheimer’s disease (LOAD). However, it's unknown how RASIP1 mutation contributes to disease.^[8]

Notes and References

1. Web site: RASIP1 - Ras-interacting protein 1 - Homo sapiens (Human) - RASIP1 gene & protein. 2021-12-11. www.uniprot.org. en. Text was copied from this source, which is available under a Creative Commons Attribution 4.0 International License.
2. Wilson CW, Ye W . Regulation of vascular endothelial junction stability and remodeling through Rap1-Rasip1 signaling . Cell Adhesion & Migration . 8 . 2 . 76–83 . 2014 . 24622510 . 4049864 . 10.4161/cam.28115 .
3. Koo Y, Barry DM, Xu K, Tanigaki K, Davis GE, Mineo C, Cleaver O . Rasip1 is essential to blood vessel stability and angiogenic blood vessel growth . Angiogenesis . 19 . 2 . 173–190 . April 2016 . 26897025 . 4808411 . 10.1007/s10456-016-9498-5 .
4. Liu X, Gu X, Ma W, Oxendine M, Gil HJ, Davis GE, Cleaver O, Oliver G . Rasip1 controls lymphatic vessel lumen maintenance by regulating endothelial cell junctions . Development . 145 . 17 . dev165092 . August 2018 . 30042182 . 6141773 . 10.1242/dev.165092 .
5. Xu K, Chong DC, Rankin SA, Zorn AM, Cleaver O . Rasip1 is required for endothelial cell motility, angiogenesis and vessel formation . Developmental Biology . 329 . 2 . 269–279 . May 2009 . 19272373 . 2683470 . 10.1016/j.ydbio.2009.02.033 .
6. Barry DM, Koo Y, Norden PR, Wylie LA, Xu K, Wichaidit C, Azizoglu DB, Zheng Y, Cobb MH, Davis GE, Cleaver O . Rasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel Tubulogenesis via Nonmuscle Myosin II . Circulation Research . 119 . 7 . 810–826 . September 2016 . 27486147 . 5026621 . 10.1161/CIRCRESAHA.116.309094 .
7. Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ . Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization . English . The Journal of Biological Chemistry . 279 . 21 . 22353–22361 . May 2004 . 15031288 . 10.1074/jbc.M312867200 . free .
8. Wightman DP, Jansen IE, Savage JE, Shadrin AA, Bahrami S, Holland D, Rongve A, Børte S, Winsvold BS, Drange OK, Martinsen AE, Skogholt AH, Willer C, Bråthen G, Bosnes I, Nielsen JB, Fritsche LG, Thomas LF, Pedersen LM, Gabrielsen ME, Johnsen MB, Meisingset TW, Zhou W, Proitsi P, Hodges A, Dobson R, Velayudhan L, Heilbron K, Auton A, Sealock JM, Davis LK, Pedersen NL, Reynolds CA, Karlsson IK, Magnusson S, Stefansson H, Thordardottir S, Jonsson PV, Snaedal J, Zettergren A, Skoog I, Kern S, Waern M, Zetterberg H, Blennow K, Stordal E, Hveem K, Zwart JA, Athanasiu L, Selnes P, Saltvedt I, Sando SB, Ulstein I, Djurovic S, Fladby T, Aarsland D, Selbæk G, Ripke S, Stefansson K, Andreassen OA, Posthuma D . A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease . Nature Genetics . 53 . 9 . 1276–1282 . September 2021 . 34493870 . 10.1038/s41588-021-00921-z . 10243600 . 237442349 . 1871.1/61f01aa9-6dc7-4213-be2a-d3fe622db488 . free .