CD151 explained

CD151 molecule (Raph blood group), also known as CD151 (Cluster of Differentiation 151), is a human gene.^[1]

Function

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. Abnormalities in CD151 have been implicated in a form of epidermolysis bullosa.^{[2] [3]}

Interactions

CD151 has been shown to interact with CD46.^[4]

See also

• Cluster of differentiation
• Tetraspanin

Further reading

• Berditchevski F . Complexes of tetraspanins with integrins: more than meets the eye . Journal of Cell Science . 114 . Pt 23 . 4143–4151 . December 2001 . 11739647 . 10.1242/jcs.114.23.4143 .
• Ashman LK . CD151 . Journal of Biological Regulators and Homeostatic Agents . 16 . 3 . 223–226 . 2003 . 12456024 .
• Ashman LK, Aylett GW, Mehrabani PA, Bendall LJ, Niutta S, Cambareri AC, Cole SR, Berndt MC . The murine monoclonal antibody, 14A2.H1, identifies a novel platelet surface antigen . British Journal of Haematology . 79 . 2 . 263–270 . October 1991 . 1958484 . 10.1111/j.1365-2141.1991.tb04531.x . 6682391 .
• Fitter S, Tetaz TJ, Berndt MC, Ashman LK . Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3 . Blood . 86 . 4 . 1348–1355 . August 1995 . 7632941 . 10.1182/blood.V86.4.1348.bloodjournal8641348 . free . free . 2440/103301 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–174 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Hasegawa H, Utsunomiya Y, Kishimoto K, Yanagisawa K, Fujita S . SFA-1, a novel cellular gene induced by human T-cell leukemia virus type 1, is a member of the transmembrane 4 superfamily . Journal of Virology . 70 . 5 . 3258–3263 . May 1996 . 8627808 . 190191 . 10.1128/JVI.70.5.3258-3263.1996 .
• Hasegawa H, Kishimoto K, Yanagisawa K, Terasaki H, Shimadzu M, Fujita S . Assignment of SFA-1 (PETA-3), a member of the transmembrane 4 superfamily, to human chromosome 11p15.5 by fluorescence in situ hybridization . Genomics . 40 . 1 . 193–196 . February 1997 . 9070943 . 10.1006/geno.1996.4563 .
• Sincock PM, Mayrhofer G, Ashman LK . Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: comparison with CD9, CD63, and alpha5beta1 integrin . The Journal of Histochemistry and Cytochemistry . 45 . 4 . 515–525 . April 1997 . 9111230 . 10.1177/002215549704500404 . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–156 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Fitter S, Seldin MF, Ashman LK . Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1398 . 1 . 75–85 . May 1998 . 9602068 . 10.1016/S0167-4781(98)00034-7 .
• Sincock PM, Fitter S, Parton RG, Berndt MC, Gamble JR, Ashman LK . PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function . Journal of Cell Science . 112 (Pt 6) . 6 . 833–844 . March 1999 . 10036233 . 10.1242/jcs.112.6.833 . free . 2440/8940 .
• Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, Rubinstein E . Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions . The Biochemical Journal . 340 (Pt 1) . Pt 1 . 103–111 . May 1999 . 10229664 . 1220227 . 10.1042/0264-6021:3400103 .
• Testa JE, Brooks PC, Lin JM, Quigley JP . Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin (PETA-3/CD151) as an effector of human tumor cell migration and metastasis . Cancer Research . 59 . 15 . 3812–3820 . August 1999 . 10447000 .
• Sterk LM, Geuijen CA, Oomen LC, Calafat J, Janssen H, Sonnenberg A . The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes . The Journal of Cell Biology . 149 . 4 . 969–982 . May 2000 . 10811835 . 2174566 . 10.1083/jcb.149.4.969 .
• Whittock NV, McLean WH . Genomic organization, amplification, fine mapping, and intragenic polymorphisms of the human hemidesmosomal tetraspanin CD151 gene . Biochemical and Biophysical Research Communications . 281 . 2 . 425–430 . February 2001 . 11181065 . 10.1006/bbrc.2001.4384 .
• Charrin S, Le Naour F, Oualid M, Billard M, Faure G, Hanash SM, Boucheix C, Rubinstein E . The major CD9 and CD81 molecular partner. Identification and characterization of the complexes . The Journal of Biological Chemistry . 276 . 17 . 14329–14337 . April 2001 . 11278880 . 10.1074/jbc.M011297200 . free .
• Suzuki Y, Tsunoda T, Sese J, Taira H, Mizushima-Sugano J, Hata H, Ota T, Isogai T, Tanaka T, Nakamura Y, Suyama A, Sakaki Y, Morishita S, Okubo K, Sugano S . Identification and characterization of the potential promoter regions of 1031 kinds of human genes . Genome Research . 11 . 5 . 677–684 . May 2001 . 11337467 . 311086 . 10.1101/gr.gr-1640r .
• Kohno M, Hasegawa H, Miyake M, Yamamoto T, Fujita S . CD151 enhances cell motility and metastasis of cancer cells in the presence of focal adhesion kinase . International Journal of Cancer . 97 . 3 . 336–343 . January 2002 . 11774285 . 10.1002/ijc.1605 . 46569418 .
• Zhang XA, Kazarov AR, Yang X, Bontrager AL, Stipp CS, Hemler ME . Function of the tetraspanin CD151-alpha6beta1 integrin complex during cellular morphogenesis . Molecular Biology of the Cell . 13 . 1 . 1–11 . January 2002 . 11809818 . 65068 . 10.1091/mbc.01-10-0481 .

External links

• Raph blood group system in the BGMUT blood group antigen gene mutation database

Notes and References

1. Web site: Entrez Gene: CD151 CD151 molecule (Raph blood group).
2. Bardhan A, Bruckner-Tuderman L, Chapple IL, Fine JD, Harper N, Has C, Magin TM, Marinkovich MP, Marshall JF, McGrath JA, Mellerio JE, Polson R, Heagerty AH . Epidermolysis bullosa . Nature Reviews. Disease Primers . 6 . 1 . 78 . September 2020 . 32973163 . 10.1038/s41572-020-0210-0 . 221861310 .
3. Vahidnezhad H, Youssefian L, Saeidian AH, Mahmoudi H, Touati A, Abiri M, Kajbafzadeh AM, Aristodemou S, Liu L, McGrath JA, Ertel A, Londin E, Kariminejad A, Zeinali S, Fortina P, Uitto J . Recessive mutation in tetraspanin CD151 causes Kindler syndrome-like epidermolysis bullosa with multi-systemic manifestations including nephropathy . Matrix Biology . 66 . 22–33 . March 2018 . 29138120 . 10.1016/j.matbio.2017.11.003 . free . 3812225 . 11573/1182681 .
4. Lozahic S, Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, Rubinstein E . CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans . European Journal of Immunology . 30 . 3 . 900–907 . March 2000 . 10741407 . 10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X . free .