Raoultella terrigena explained

Raoultella terrigena is a Gram-negative bacterial species of the genus Raoultella, previously classified in the genus Klebsiella.[1] It has primarily been isolated from soil and water samples,[2] but rarely from humans. Studies have estimated fewer than 1% of healthy people harbor this species.[3] This species has rarely been shown to cause disease[4] in humans despite expressing many of the virulence factors expressed by other Klebsiella species such as Klebsiella pneumoniae.[5]

Phylogenic comparisons between the 16s rRNA and rpoB genes of this and other Klebsiella species have suggested classification into a newer genus, Raoultella, a reclassification that has been adopted.[6]

R. terrigena is considered a factor in melamine toxicity. In culture, R. terrigena was shown to convert melamine to cyanuric acid directly. Rats colonized by R. terrigena showed greater melamine-induced kidney damage compared to those not colonized.[7]

Notes and References

  1. Drancourt M, Bollet C, Carta A, Rousselier P . Phylogenetic analyses of Klebsiella species delineate Klebsiella and Raoultella gen. nov., with description of Raoultella ornithinolytica comb. nov., Raoultella terrigena comb. nov. and Raoultella planticola comb. nov . International Journal of Systematic and Evolutionary Microbiology . 51 . Pt 3 . 925–932 . May 2001 . 11411716 . 10.1099/00207713-51-3-925 .
  2. Izard D, Ferragut C, Gavini F, Kersters K, De Ley J, Leclerc H . Klebsiella terrigena, a new species from soil and water . International Journal of Systematic Bacteriology . 1 April 1981 . 31 . 2 . 116–127 . 10.1099/00207713-31-2-116. free .
  3. Web site: Neergaard L . Study Examines Why Most Survived China's Melamine Scare . Food Manufacturing News . Food Manufacturing . 22 February 2013 . 5 July 2015 . https://web.archive.org/web/20150705185736/http://www.foodmanufacturing.com/news/2013/02/study-examines-why-most-survived-chinas-melamine-scare . dead .
  4. Lekhniuk N, Fesenko U, Pidhirnyi Y, Sękowska A, Korniychuk O, Konechnyi Y . Raoultella terrigena: Current state of knowledge, after two recently identified clinical cases in Eastern Europe . Clinical Case Reports . 9 . 5 . e04089 . May 2021 . 34026135 . 8123537 . 10.1002/ccr3.4089 .
  5. Podschun R, Fischer A, Ullmann U . Characterization of Klebsiella terrigena strains from humans: haemagglutinins, serum resistance, siderophore synthesis, and serotypes . Epidemiology and Infection . 125 . 1 . 71–78 . August 2000 . 11057961 . 2869571 . 10.1017/S0950268899004124 .
  6. Web site: Results for "raoultella" . Euzéby JP . List of Prokaryotic names with Standing in Nomenclature – integrated into the DSMZ’s Prokaryotic Nomenclature Up-to-date (PNU) database .
  7. Zheng X, Zhao A, Xie G, Chi Y, Zhao L, Li H, Wang C, Bao Y, Jia W, Luther M, Su M, Nicholson JK, Jia W . 6 . Melamine-induced renal toxicity is mediated by the gut microbiota . Science Translational Medicine . 5 . 172 . 172ra22 . February 2013 . 23408055 . 10.1126/scitranslmed.3005114 . 23408614 .

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