Randy Read Explained

Randy Read
Birth Name:Randy John Read
Birth Date:1957 6, df=yes
Workplaces:University of Cambridge
Alma Mater:University of Alberta (BSc, PhD)
Thesis Title:X-ray crystallographic studies on serine proteinases and their protein inhibitors
Thesis Url:http://hdl.handle.net/10402/era.3098
Thesis Year:1986
Known For:[1]
Doctoral Advisor:Michael N. G. James[2]
Awards:Wellcome Trust Principal Research Fellow

Randy John Read [3] (born 9 June 1957) is a Wellcome Trust Principal Research Fellow and professor of protein crystallography at the University of Cambridge.[4]

Education

Read was educated at the University of Alberta in Edmonton, Canada where he was awarded a Bachelor of Science degree in 1979 followed by a PhD in 1986 for X-ray crystallography of serine proteases and their protein inhibitors supervised by Michael N. G. James.[2] [5]

Career and research

Following his PhD, Read was appointed assistant professor from 1988 to 1993 and associate professor from 1993 to 1998 at the University of Alberta., Read's research interests are in protein crystallography and maximum likelihood estimation. His research has been published in leading peer reviewed scientific journals including Nature,[6] [7] [8] Science,[9] the Journal of Applied Crystallography[10] Acta Crystallographica,[11] [12] [13] Structure,[14] [15] PNAS,[16] the Journal of Molecular Biology[17] [18] and the Journal of Clinical Endocrinology and Metabolism.[19]

Awards and honours

Read was elected Fellow of the Royal Society (FRS) in 2014. His nomination reads:

Notes and References

  1. Liebschner . Dorothee . Afonine . Pavel V. . Baker . Matthew L. . Bunkóczi . Gábor . Chen . Vincent B. . Croll . Tristan I. . Hintze . Bradley . Hung . Li-Wei . Jain . Swati . McCoy . Airlie J. . Moriarty . Nigel W. . Oeffner . Robert D. . Poon . Billy K. . Prisant . Michael G. . Read . Randy J. . 2019-10-01 . Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix . Acta Crystallographica Section D: Structural Biology . 75 . 10 . 861–877 . 10.1107/S2059798319011471 . 2059-7983 . 6778852 . 31588918. 2019AcCrD..75..861L .
  2. Fujinaga. Masao. Sielecki. Anita R.. Read. Randy J.. Ardelt. Wojciech. Laskowski. Michael. James. Michael N.G.. Crystal and molecular structures of the complex of α-chymotrypsin with its inhibitor Turkey ovomucoid third domain at 1.8 Å resolution. Journal of Molecular Biology. 195. 2. 1987. 397–418. 0022-2836. 10.1016/0022-2836(87)90659-0. 3477645.
  3. Web site: Professor Randy Read FRS . royalsociety.org . Anon. 2014. 2014-08-05. https://web.archive.org/web/20140805043415/https://royalsociety.org/people/fellowship/2014/randy-read/ . London.
  4. Web site: https://web.archive.org/web/20130515145812/http://www-structmed.cimr.cam.ac.uk/Personal/randy/. 2013-05-15. Randy Read's Homepage. University of Cambridge. Randy. Read. 2017.
  5. PhD . Randy John. Read . X-ray crystallographic studies on serine proteinases and their protein inhibitors. 1986 . Randy Read. 10.7939/R33776175. 10402/era.3098. .
  6. 10.1038/nature09505. 20927107. 3024006. A redox switch in angiotensinogen modulates angiotensin release. Nature. 468. 7320. 108–11. 2010. Zhou . A. . Carrell . R. W. . Murphy . M. P. . Wei . Z. . Yan . Y. . Stanley . P. L. D. . Stein . P. E. . Pipkin . F. B. . Read . R. J. . 2010Natur.468..108Z.
  7. 10.1038/nature09964. 21532589. Improved molecular replacement by density- and energy-guided protein structure optimization. Nature. 473. 7348. 540–3. 2011. Dimaio . F. . Terwilliger . T. C. . Read . R. J. . Randy Read. Wlodawer . A. . Oberdorfer . G. . Wagner . U. . Valkov . E. . Alon . A. . Fass . D. . Axelrod . H. L. . Das . D. . Vorobiev . S. M. . Iwaï . H. . Pokkuluri . P. R. . Baker . D. . David Baker (biochemist) . 3365536. 2011Natur.473..540D.
  8. 10.1038/nature06249. 17934447. High-resolution structure prediction and the crystallographic phase problem. Nature. 450. 7167. 259–64. 2007. Qian . B. . Raman . S. . Das . R. . Bradley . P. . McCoy . A. J. . Read . R. J. . Randy Read. Baker . D. . David Baker (biochemist) . 2504711. 2007Natur.450..259Q.
  9. 25103409. 4188430. 2014. Jackson. R. N.. Structural biology. Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli. Science. 345. 6203. 1473–9. Golden. S. M.. Van Erp. P. B.. Carter. J. Westra. E. R.. Brouns. S. J.. Van Der Oost. J. Terwilliger. T. C.. Read. R. J.. Wiedenheft. B. 10.1126/science.1256328.
  10. 10.1107/S0021889807021206. 19461840. Phaser crystallographic software. Journal of Applied Crystallography. 40. 4. 658–674. 2007. McCoy . A. J. . Grosse-Kunstleve . R. W. . Adams . P. D. . Winn . M. D. . Storoni . L. C. . Read . R. J. . 2483472. 2007JApCr..40..658M. Randy Read. 10.1.1.322.8550.
  11. 10.1107/S0907444909052925. PHENIX: A comprehensive Python-based system for macromolecular structure solution. Acta Crystallographica Section D. 66. 2. 213–21. 2010. Adams . P. D. . Afonine . P. V. . Bunkóczi . G. B. . Chen . V. B. . Davis . I. W. . Echols . N. . Headd . J. J. . Hung . L. W. . Kapral . G. J. . Grosse-Kunstleve . R. W. . McCoy . A. J. . Moriarty . N. W. . Oeffner . R. . Read . R. J. . Richardson . D. C. . Richardson . J. S. . Terwilliger . T. C. . Zwart . P. H. . 20124702 . 2815670. 2010AcCrD..66..213A.
  12. 10.1107/S0907444998003254. Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination. Acta Crystallographica Section D. 54. 5. 905–21. 1998. Brünger . A. T.. Adams . P. D.. Clore . G. M.. Delano . W. L.. Gros . P.. Grosse-Kunstleve . R. W.. Jiang . J. S.. Kuszewski . J.. Nilges . M.. Pannu . N. S.. Read . R. J.. Rice . L. M.. Simonson . T.. Warren . G. L. . 9757107. 1998AcCrD..54..905B. 33910776.
  13. 19171969. 2631636. 2009. Read. R. J. . Randy Read. Case-controlled structure validation. Acta Crystallographica Section D. 65. Pt 2. 140–7. Kleywegt. G. J. . Gerard Kleywegt. 10.1107/S0907444908041085. 2009AcCrD..65..140R.
  14. 22000512. 3195755. 2011. Read. R. J.. A new generation of crystallographic validation tools for the protein data bank. Structure. 19. 10. 1395–412. Adams. P. D.. Arendall Wb. 3rd. Brunger. A. T.. Emsley. P. Joosten. R. P.. Kleywegt. G. J.. Krissinel. E. B.. Lütteke. T. Otwinowski. Z. Perrakis. A. Richardson. J. S.. Sheffler. W. H.. Smith. J. L.. Tickle. I. J.. Vriend. G. Zwart. P. H.. 10.1016/j.str.2011.08.006.
  15. 9438862. 1997. Kleywegt. G. J. . Gerard Kleywegt. Not your average density. Structure. 5. 12. 1557–69. Read. R. J.. Randy Read . 10.1016/s0969-2126(97)00305-5. free.
  16. 21876145. 3174575. 2011. Deane. J. E.. Insights into Krabbe disease from structures of galactocerebrosidase. Proceedings of the National Academy of Sciences. 108. 37. 15169–73. Graham. S. C.. Kim. N. N.. Stein. P. E.. McNair. R. Cachón-González. M. B.. Cox. T. M.. Read. R. J.. 10.1073/pnas.1105639108. free.
  17. 18513745. 2008. Zhou. A. The S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone release. Journal of Molecular Biology. 380. 1. 244–51. Wei. Z. Stanley. P. L.. Read. R. J.. Stein. P. E.. Carrell. R. W.. 10.1016/j.jmb.2008.05.012. free.
  18. Stoop . A. A. . Eldering . E . Dafforn . T. R. . Read . R. J. . Pannekoek . H . 2001 . Different structural requirements for plasminogen activator inhibitor 1 (PAI-1) during latency transition and proteinase inhibition as evidenced by phage-displayed hypermutated PAI-1 libraries . Journal of Molecular Biology . 305 . 4 . 773–83 . 10.1006/jmbi.2000.4356 . 11162091 . 6 May 2022 . 6 May 2022 . https://web.archive.org/web/20220506091632/https://pubmed.ncbi.nlm.nih.gov/11162091/ . live .
  19. 23783094. 3813945. 2013. Chan. W. L.. How changes in affinity of corticosteroid-binding globulin modulate free cortisol concentration. The Journal of Clinical Endocrinology & Metabolism. 98. 8. 3315–22. Carrell. R. W.. Zhou. A. Read. R. J.. 10.1210/jc.2012-4280.

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