Ralph DeBerardinis explained
Ralph J. DeBerardinis |
Fields: | Cancer;Metabolism |
Thesis Title: | Retrotransposition and evolution of L1 sequences in mammalian genomes |
Thesis Year: | 1998 |
Doctoral Advisor: | Haig H. Kazazian Jr |
Academic Advisors: | Craig Thompson |
Awards: | Paul Marks Prize for Cancer Research;Edith and Peter O'Donnell Award in Medicine |
Website: | https://cri.utsw.edu/scientists/ralph-deberardinis-laboratory/ |
Ralph J. DeBerardinis is an American physician-scientist, the chief of the Division of Pediatric Genetics and Metabolism at the Children’s Medical Center Research Institute at UT Southwestern and a professor at the University of Texas Southwestern Medical Center. DeBerardinis became a Howard Hughes Medical Institute Investigator in 2018.[1] DeBerardinis was elected to the National Academy of Medicine in 2020.[2] DeBerardinis is known for his contributions to research on cancer and pediatric inborn errors of metabolism.
Biography
DeBerardinis was born and raised in the Philadelphia area.[3] DeBerardinis received a Bachelor of Science (BS) degree from St. Joseph’s University and M.D. and Ph.D. degrees from the University of Pennsylvania.[4] [5] DeBerardinis completed his Ph.D. in the laboratory of Haig H. Kazazian Jr.[6] DeBerardinis was an inaugural trainee of the combined Pediatrics/Genetics Residency program at The Children’s Hospital of Philadelphia (CHOP). DeBerardinis has achieved board certifications in clinical biochemical genetics, medical genetics, and pediatrics. DeBerardinis performed his postdoctoral research in the laboratory of Craig Thompson while he was at the Penn Cancer Center.[7] After completing his postdoctoral work, DeBerardinis opened his own research laboratory in 2008 at University of Texas Southwestern Medical Center.
DeBerardinis has been on the Scientific Advisory Boards of several companies, including Agios Pharmaceuticals, Peloton Therapeutics, and Vida Ventures.[8] As of April 2022, DeBerardinis has authored over 350 publications and has an h-index of 94.[9]
Scientific contributions
DeBerardinis is well known for his use of isotope-tracing metabolomics to identify how tumors utilize different nutrients. Using genomics and metabolomics approaches, DeBerardinis also has worked to identify novel mutations that affect the activity of metabolic enzymes.[10]
Selected awards and honors
Selected publications
- Mullen . Andrew R. . Wheaton . William W. . Jin . Eunsook S. . Chen . Pei-Hsuan . Sullivan . Lucas B. . Cheng . Tzuling . Yang . Youfeng . Linehan . W. Marston . Chandel . Navdeep S. . DeBerardinis . Ralph J. . Reductive carboxylation supports growth in tumour cells with defective mitochondria . Nature . January 2012 . 481 . 7381 . 385–388 . 10.1038/nature10642 . 22101431 . 3262117 . 2012Natur.481..385M .
- Marin-Valencia . Isaac . Yang . Chendong . Mashimo . Tomoyuki . Cho . Steve . Baek . Hyeonman . Yang . Xiao-Li . Rajagopalan . Kartik N. . Maddie . Melissa . Vemireddy . Vamsidhara . Zhao . Zhenze . Cai . Ling . Good . Levi . Tu . Benjamin P. . Hatanpaa . Kimmo J. . Mickey . Bruce E. . Matés . José M. . Pascual . Juan M. . Maher . Elizabeth A. . Malloy . Craig R. . DeBerardinis . Ralph J. . Bachoo . Robert M. . Analysis of Tumor Metabolism Reveals Mitochondrial Glucose Oxidation in Genetically Diverse Human Glioblastomas in the Mouse Brain In Vivo . Cell Metabolism . June 2012 . 15 . 6 . 827–837 . 10.1016/j.cmet.2012.05.001 . 22682223 . 3372870 .
- Tasdogan . Alpaslan . Faubert . Brandon . Ramesh . Vijayashree . Ubellacker . Jessalyn M. . Shen . Bo . Solmonson . Ashley . Murphy . Malea M. . Gu . Zhimin . Gu . Wen . Martin . Misty . Kasitinon . Stacy Y. . Vandergriff . Travis . Mathews . Thomas P. . Zhao . Zhiyu . Schadendorf . Dirk . DeBerardinis . Ralph J. . Morrison . Sean J. . Metabolic heterogeneity confers differences in melanoma metastatic potential . Nature . 2 January 2020 . 577 . 7788 . 115–120 . 10.1038/s41586-019-1847-2 . 31853067 . 6930341 .
- Hensley . Christopher T. . Faubert . Brandon . Yuan . Qing . Lev-Cohain . Naama . Jin . Eunsook . Kim . Jiyeon . Jiang . Lei . Ko . Bookyung . Skelton . Rachael . Loudat . Laurin . Wodzak . Michelle . Klimko . Claire . McMillan . Elizabeth . Butt . Yasmeen . Ni . Min . Oliver . Dwight . Torrealba . Jose . Malloy . Craig R. . Kernstine . Kemp . Lenkinski . Robert E. . DeBerardinis . Ralph J. . Metabolic Heterogeneity in Human Lung Tumors . Cell . February 2016 . 164 . 4 . 681–694 . 10.1016/j.cell.2015.12.034 . 26853473 . 4752889 .
- Faubert . Brandon . Li . Kevin Y. . Cai . Ling . Hensley . Christopher T. . Kim . Jiyeon . Zacharias . Lauren G. . Yang . Chendong . Do . Quyen N. . Doucette . Sarah . Burguete . Daniel . Li . Hong . Huet . Giselle . Yuan . Qing . Wigal . Trevor . Butt . Yasmeen . Ni . Min . Torrealba . Jose . Oliver . Dwight . Lenkinski . Robert E. . Malloy . Craig R. . Wachsmann . Jason W. . Young . Jamey D. . Kernstine . Kemp . DeBerardinis . Ralph J. . Lactate Metabolism in Human Lung Tumors . Cell . October 2017 . 171 . 2 . 358–371.e9 . 10.1016/j.cell.2017.09.019 . 28985563 . 5684706 .
References
- Web site: Ralph J. DeBerardinis . 2022-04-24 . HHMI . en.
- Web site: 2020-10-19 . National Academy of Medicine Elects 100 New Members . 2022-04-24 . National Academy of Medicine . en-US.
- Web site: Ralph DeBerardinis - Scientific Advisory Board Member at Vida Ventures . 2022-04-24 . THE ORG . en.
- Web site: Ralph DeBerardinis Laboratory Children's Research Institute Dallas TX . 2022-04-24 . Children's Research Institute Dallas Texas . en-US.
- Web site: children's health . Biography: Ralph John DeBerardinis, MD . 2022-04-23.
- DeBerardinis . Ralph John . 1998 . Retrotransposition and evolution of L1 sequences in mammalian genomes . . 187477554 .
- Web site: Meet Ralph DeBerardinis, a Recipient of the Paul Marks Prize for Cancer Research Memorial Sloan Kettering Cancer Center . 2022-04-24 . www.mskcc.org . 28 February 2022 . en.
- Web site: Leadership . 2022-04-24 . Agios . en-US.
- Web site: Ralph DeBerardinis . 2022-04-24 . scholar.google.com.
- Web site: Ralph DeBerardinis, MD, PhD . 2022-04-24 . HHMI . en.
- Web site: 2018-10-15 . 2017 Outstanding Investigator Award (OIA) Recipients - National Cancer Institute . 2022-04-24 . www.cancer.gov . en.
- Web site: 2019 O'Donnell Awards Recipients - TAMEST . 2022-04-24 . TAMEST The Academy of Medicine, Engineering and Science of Texas . en-US.