| Position: | Center |
| Birth Date: | 15 December 1898 |
| Birth Place: | Blue Grass, Iowa, U.S. |
| Death Place: | Webster Groves, Missouri, U.S. |
| College: | Purdue |
| Pastteams: |
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| Statlabel1: | Games played |
| Statvalue1: | 30 |
| Statlabel2: | Games started |
| Statvalue2: | 28 |
| Highlights: |
Ralph LeClair Claypool (December 15, 1898 – November 17, 1969) was an American football center who played professionally for four seasons, from 1925 to 1928, with the Chicago Cardinals of the National Football League (NFL). Claypool played college football at Purdue University.