| Rafaela Bezanilla | |
| Office: | First Lady of Chile |
| Term Label: | In role |
| President: | José Tomás Ovalle |
| Birth Name: | Rafaela Bezanilla Bezanilla |
| Birth Place: | Santiago, Viceroyalty of Peru |
| Nationality: | Chilean |
| Spouse: | José Tomás Ovalle |
| Children: | 8 |
| Parents: | Francisco de Bezanilla y de la Bárcena Juana Bezanilla y Abós Padilla |
Rafaela Bezanilla Bezanilla (1797 – 7 May 1855) was First Lady of Chile and the wife of President José Tomás Ovalle y Bezanilla. She was born in Santiago, the daughter of Francisco de Bezanilla y de la Bárcena and of Juana Bezanilla y Abós Padilla. She and her husband had eight children together.