Raf kinase inhibitor protein explained

The Raf kinase inhibitor protein (RKIP) is a kinase inhibitor protein, that regulates many signaling pathways within the cell.^[1] RKIP is a member of the phosphatidylethanolamine-binding protein family and has displayed disruptive regulation on the Raf-1-MEK1/2, ERK1/2 and NF-kappaB signalling pathways, by interaction with the Raf-1 kinase.

RKIP has also been shown to inhibit G protein coupled receptor kinases (GRK) when phosphorylated by protein kinase C.^[2] Via this mechanism it has been shown to exert beneficial effects on cardiac structure and function.^[3]

Notes and References

1. Book: Odabaei, Golaun . Advances in Cancer Research . Chatterjee . Devasis . Jazirehi . Ali R. . Goodglick . Lee . Yeung . Kam . Bonavida . Benjamin . 2004 . Elsevier . 978-0-12-006691-9 . Vande Woude . George F. . 91 . 169-200 . Raf-1 Kinase Inhibitor Protein: Structure, Function, Regulation of Cell Signaling, and Pivotal Role in Apoptosis . 10.1016/S0065-230X(04)91005-6 . 0065-230X . 15327891 . Klein . George . https://archive.org/details/advancesincancer0000unse_n0p5/page/168/mode/2up . 21758249.
2. Lorenz . Kristina . Lohse . Martin J. . Quitterer . Ursula . 4 December 2003 . Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2 . Nature . 426 . 6966 . 574–579 . 10.1038/nature02158 . 1476-4687 . 14654844 . 4431750 . .
3. Schmid . Evelyn . Neef . Stefan . Berlin . Christopher . Tomasovic . Angela . Kahlert . Katrin . Nordbeck . Peter . Deiss . Katharina . Denzinger . Sabrina . Herrmann . Sebastian . Wettwer . Erich . Weidendorfer . Markus . Becker . Daniel . Schäfer . Florian . Wagner . Nicole . Ergün . Süleyman . 19 October 2015 . Cardiac RKIP induces a beneficial β-adrenoceptor-dependent positive inotropy . Nature Medicine . 21 . 11 . 1298–1306 . 10.1038/nm.3972 . 1546-170X . 26479924 . 11418537 . .