Radula marginata explained

Radula marginata, or Wairuakohu, is a species of plant in the genus Radula,[1] a genus of liverworts. It is endemic to New Zealand.[2] [3] It has been found to contain cannabinoids.[4] [5]

Cannabinoids

Users smoking the plant have experienced different effects.[6] The cannabinoid is not THC, the main psychoactive chemical in cannabis, but it is of similar molecular structure.[4] The liverwort contains perrottetinene and perrottetinenic acid.[4] The quantity of cannabinoid present is much less than in cannabis. Perrottetinene has been shown to be a moderately potent CB1 agonist leading to mild psychoactive effects in mice.[7]

Legal status

The liverwort grows as a common weed. Owning, growing and distributing the liverwort is legal.

Radula marginata may have been used in rongoā (Māori herbal medicine), but there is no firm evidence of this.

Notes and References

  1. 10.1007/s11101-019-09638-8. Demystifying the liverwort Radula marginata, a critical review on its taxonomy, genetics, cannabinoid phytochemistry and pharmacology. Phytochemistry Reviews. 18. 3. 953–965. 2019. Hussain. Tajammul. Espley. Richard V.. Gertsch. Jürg. Whare. Tracey. Stehle. Felix. Kayser. Oliver. 199517648.
  2. Web site: GBIF2550163 . Discover Life . 2013-05-21 . 2022-08-25.
  3. Web site: GBIF2550057 . Discover Life . 2013-05-21 . 2022-08-25.
  4. Toyota . M. . etal . 2002 . New bibenzyl cannabinoid from the New Zealand liverwort Radula marginata . Chem Pharm Bull . 50 . 10. 1390–1392 . 10.1248/cpb.50.1390. 12372871 . free .
  5. 10.3389/fpls.2018.00537. 29868043. 5954354. Identification of Putative Precursor Genes for the Biosynthesis of Cannabinoid-Like Compound in Radula marginata. Frontiers in Plant Science. 9. 537. 2018. Hussain. Tajammul. Plunkett. Blue. Ejaz. Mahwish. Espley. Richard V.. Kayser. Oliver. free.
  6. Web site: Radula Marginata (Perrottetinene) - TripMe Forums - Life Drugs Music Knowledge . www.tripme.co.nz . dead . https://web.archive.org/web/20100515015135/http://tripme.co.nz/forums/showthread.php?t=1943 . 2010-05-15.
  7. Chicca. A.. Schafroth. M. A.. Reynoso-Moreno. I.. Erni. R.. Petrucci. V.. Carreira. E. M.. Gertsch. J.. 2018-10-01. Uncovering the psychoactivity of a cannabinoid from liverworts associated with a legal high. Science Advances. en. 4. 10. eaat2166. 10.1126/sciadv.aat2166. 2375-2548. 30397641. 6200358. 2018SciA....4.2166C.

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