Radixin Explained

Radixin is a protein that in humans is encoded by the RDX gene.^{[1] [2] [3]}

Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses.

Interactions

Radixin has been shown to interact with GNA13.^[4]

See also

• ERM protein family

Further reading

• Hoeflich KP, Ikura M . Radixin: cytoskeletal adopter and signaling protein . Int. J. Biochem. Cell Biol. . 36 . 11 . 2131–6 . 2005 . 15313460 . 10.1016/j.biocel.2003.11.018 .
• Matarrese P, Malorni W . Human immunodeficiency virus (HIV)-1 proteins and cytoskeleton: partners in viral life and host cell death . Cell Death Differ. . 12 . 932–41 . 2006 . Suppl 1 . 15818415 . 10.1038/sj.cdd.4401582 . free .
• Sato N, Funayama N, Nagafuchi A, Yonemura S, Tsukita S, Tsukita S . A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites . J. Cell Sci. . 103 . 1 . 131–43 . 1992 . 10.1242/jcs.103.1.131 . 1429901 .
• Hirao M, Sato N, Kondo T, Yonemura S, Monden M, Sasaki T, Takai Y, Tsukita S, Tsukita S . Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway . J. Cell Biol. . 135 . 1 . 37–51 . 1996 . 8858161 . 2121020 . 10.1083/jcb.135.1.37 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Stemmer-Rachamimov AO, Gonzalez-Agosti C, Xu L, Burwick JA, Beauchamp R, Pinney D, Louis DN, Ramesh V . Expression of NF2-encoded merlin and related ERM family proteins in the human central nervous system . J. Neuropathol. Exp. Neurol. . 56 . 6 . 735–42 . 1997 . 9184664 . 10.1097/00005072-199756060-00011 . free .
• Takahashi K, Sasaki T, Mammoto A, Takaishi K, Kameyama T, Tsukita S, Takai Y . Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein . J. Biol. Chem. . 272 . 37 . 23371–5 . 1997 . 9287351 . 10.1074/jbc.272.37.23371 . free .
• Kondo T, Takeuchi K, Doi Y, Yonemura S, Nagata S, Tsukita S . ERM (Ezrin/Radixin/Moesin)-based Molecular Mechanism of Microvillar Breakdown at an Early Stage of Apoptosis . J. Cell Biol. . 139 . 3 . 749–58 . 1997 . 9348291 . 2141718 . 10.1083/jcb.139.3.749 .
• Murthy A, Gonzalez-Agosti C, Cordero E, Pinney D, Candia C, Solomon F, Gusella J, Ramesh V . NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins . J. Biol. Chem. . 273 . 3 . 1273–6 . 1998 . 9430655 . 10.1074/jbc.273.3.1273 . free .
• Matsui T, Maeda M, Doi Y, Yonemura S, Amano M, Kaibuchi K, Tsukita S, Tsukita S . Rho-Kinase Phosphorylates COOH-terminal Threonines of Ezrin/Radixin/Moesin (ERM) Proteins and Regulates Their Head-to-Tail Association . J. Cell Biol. . 140 . 3 . 647–57 . 1998 . 9456324 . 2140160 . 10.1083/jcb.140.3.647 .
• Yonemura S, Hirao M, Doi Y, Takahashi N, Kondo T, Tsukita S, Tsukita S . Ezrin/Radixin/Moesin (ERM) Proteins Bind to a Positively Charged Amino Acid Cluster in the Juxta-Membrane Cytoplasmic Domain of CD44, CD43, and ICAM-2 . J. Cell Biol. . 140 . 4 . 885–95 . 1998 . 9472040 . 2141743 . 10.1083/jcb.140.4.885 .
• Bhartur SG, Goldenring JR . Mapping of ezrin dimerization using yeast two-hybrid screening . Biochem. Biophys. Res. Commun. . 243 . 3 . 874–7 . 1998 . 9501018 . 10.1006/bbrc.1998.8196 .
• Takahashi K, Sasaki T, Mammoto A, Hotta I, Takaishi K, Imamura H, Nakano K, Kodama A, Takai Y . Interaction of radixin with Rho small G protein GDP/GTP exchange protein Dbl . Oncogene . 16 . 25 . 3279–84 . 1998 . 9681826 . 10.1038/sj.onc.1201874 . 21445282 .
• Lamb RF, Roy C, Diefenbach TJ, Vinters HV, Johnson MW, Jay DG, Hall A . The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho . Nat. Cell Biol. . 2 . 5 . 281–7 . 2000 . 10806479 . 10.1038/35010550 . 25353057 .
• Vaiskunaite R, Adarichev V, Furthmayr H, Kozasa T, Gudkov A, Voyno-Yasenetskaya TA . Conformational activation of radixin by G13 protein alpha subunit . J. Biol. Chem. . 275 . 34 . 26206–12 . 2000 . 10816569 . 10.1074/jbc.M001863200 . free .
• Hamada K, Shimizu T, Matsui T, Tsukita S, Tsukita S, Hakoshima T . Crystallographic characterization of the radixin FERM domain bound to the cytoplasmic tail of the adhesion protein ICAM-2 . Acta Crystallogr. D . 57 . Pt 6 . 891–2 . 2001 . 11375520 . 10.1107/S0907444901005716 . 2001AcCrD..57..891H .
• Kikuchi S, Hata M, Fukumoto K, Yamane Y, Matsui T, Tamura A, Yonemura S, Yamagishi H, Keppler D, Tsukita S, Tsukita S . Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes . Nat. Genet. . 31 . 3 . 320–5 . 2002 . 12068294 . 10.1038/ng905 . 24961102 .
• Dickson TC, Mintz CD, Benson DL, Salton SR . Functional binding interaction identified between the axonal CAM L1 and members of the ERM family . J. Cell Biol. . 157 . 7 . 1105–12 . 2002 . 12070130 . 2173555 . 10.1083/jcb.200111076 .
• Haddad LA, Smith N, Bowser M, Niida Y, Murthy V, Gonzalez-Agosti C, Ramesh V . The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton . J. Biol. Chem. . 277 . 46 . 44180–6 . 2003 . 12226091 . 10.1074/jbc.M207211200 . free .

Notes and References

1. Wilgenbus KK, Milatovich A, Francke U, Furthmayr H . Molecular cloning, cDNA sequence, and chromosomal assignment of the human radixin gene and two dispersed pseudogenes . Genomics . 16 . 1 . 199–206 . June 1993 . 8486357 . 10.1006/geno.1993.1159 . free .
2. Khan SY, Ahmed ZM, Shabbir MI, Kitajiri S, Kalsoom S, Tasneem S, Shayiq S, Ramesh A, Srisailpathy S, Khan SN, Smith RJ, Riazuddin S, Friedman TB, Riazuddin S . Mutations of the RDX gene cause nonsyndromic hearing loss at the DFNB24 locus . Hum Mutat . 28 . 5 . 417–23 . April 2007 . 17226784 . 10.1002/humu.20469 . 7671031 . free .
3. Web site: Entrez Gene: RDX radixin.
4. Vaiskunaite R, Adarichev V, Furthmayr H, Kozasa T, Gudkov A, Voyno-Yasenetskaya TA . Conformational activation of radixin by G13 protein alpha subunit . J. Biol. Chem. . 275 . 34 . 26206–12 . August 2000 . 10816569 . 10.1074/jbc.M001863200 . free .