RYBP explained

RING1 and YY1-binding protein is a protein that in humans is encoded by the RYBP gene.^{[1] [2]}

Interactions

RYBP has been shown to interact with:

• Abl gene,^[3]
• CBX2,^[1]
• Caspase 10,^[4]
• E2F2,
• E2F3,^[5]
• Mdm2,^[6]
• RING1,^{[1] [7]} and
• YY1.^[1]

Further reading

• Zhu J, Shore SK . c-ABL tyrosine kinase activity is regulated by association with a novel SH3-domain-binding protein . Molecular and Cellular Biology . 16 . 12 . 7054–62 . Dec 1996 . 8943360 . 231708 . 10.1128/mcb.16.12.7054.
• Trimarchi JM, Fairchild B, Wen J, Lees JA . The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex . Proceedings of the National Academy of Sciences of the United States of America . 98 . 4 . 1519–24 . Feb 2001 . 11171983 . 29289 . 10.1073/pnas.041597698 . free .
• Zheng L, Schickling O, Peter ME, Lenardo MJ . The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm . The Journal of Biological Chemistry . 276 . 34 . 31945–52 . Aug 2001 . 11395500 . 10.1074/jbc.M102799200 . free .
• Sawa C, Yoshikawa T, Matsuda-Suzuki F, Deléhouzée S, Goto M, Watanabe H, Sawada J, Kataoka K, Handa H . YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors . The Journal of Biological Chemistry . 277 . 25 . 22484–90 . Jun 2002 . 11953439 . 10.1074/jbc.M203060200 . free .
• Schlisio S, Halperin T, Vidal M, Nevins JR . Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function . The EMBO Journal . 21 . 21 . 5775–86 . Nov 2002 . 12411495 . 131074 . 10.1093/emboj/cdf577 .
• Guelen L, Paterson H, Gäken J, Meyers M, Farzaneh F, Tavassoli M . TAT-apoptin is efficiently delivered and induces apoptosis in cancer cells . Oncogene . 23 . 5 . 1153–65 . Feb 2004 . 14691460 . 10.1038/sj.onc.1207224 . free .
• Danen-van Oorschot AA, Voskamp P, Seelen MC, van Miltenburg MH, Bolk MW, Tait SW, Boesen-de Cock JG, Rohn JL, Borst J, Noteborn MH . Human death effector domain-associated factor interacts with the viral apoptosis agonist Apoptin and exerts tumor-preferential cell killing . Cell Death and Differentiation . 11 . 5 . 564–73 . May 2004 . 14765135 . 10.1038/sj.cdd.4401391 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M . RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1 . The EMBO Journal . 18 . 12 . 3404–18 . Jun 1999 . 10369680 . 1171420 . 10.1093/emboj/18.12.3404 .
2. Web site: Entrez Gene: RYBP RING1 and YY1 binding protein.
3. Zhu J, Shore SK . c-ABL tyrosine kinase activity is regulated by association with a novel SH3-domain-binding protein . Molecular and Cellular Biology . 16 . 12 . 7054–62 . Dec 1996 . 8943360 . 231708 . 10.1128/mcb.16.12.7054.
4. Zheng L, Schickling O, Peter ME, Lenardo MJ . The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm . The Journal of Biological Chemistry . 276 . 34 . 31945–52 . Aug 2001 . 11395500 . 10.1074/jbc.M102799200 . free .
5. Schlisio S, Halperin T, Vidal M, Nevins JR . Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function . The EMBO Journal . 21 . 21 . 5775–86 . Nov 2002 . 12411495 . 131074 . 10.1093/emboj/cdf577.
6. Chen D, Zhang J, Li M, Rayburn ER, Wang H, Zhang R . RYBP stabilizes p53 by modulating MDM2 . EMBO Reports . 10 . 2 . 166–72 . Feb 2009 . 19098711 . 2637313 . 10.1038/embor.2008.231 .
7. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M. Huda Zoghbi . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .