Relaxin/insulin-like family peptide receptor 2 explained

Relaxin/insulin-like family peptide receptor 2, also known as RXFP2, is a human G-protein coupled receptor.^[1]

The receptors for glycoprotein hormones such as follicle-stimulating hormone (FSH; see MIM 136530) and thyroid-stimulating hormone (TSH; see MIM 188540) are G protein-coupled, 7-transmembrane receptors (GPCRs) with large N-terminal extracellular domains. Leucine-rich repeat (LRR)-containing GPCRs (LGRs) form a subgroup of the GPCR superfamily. [supplied by OMIM].

See also

• Relaxin receptor

Further reading

• Bathgate RA, Ivell R, Sanborn BM, etal . Receptors for relaxin family peptides . Ann. N. Y. Acad. Sci. . 1041 . 61–76 . 2005 . 1 . 15956688 . 10.1196/annals.1282.010 . 2005NYASA1041...61B . 1185573 .
• Bathgate RA, Ivell R, Sanborn BM, etal . International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides . Pharmacol. Rev. . 58 . 1 . 7–31 . 2006 . 16507880 . 10.1124/pr.58.1.9 . 7466039 .
• Hsu SY, Nakabayashi K, Nishi S, etal . Activation of orphan receptors by the hormone relaxin . Science . 295 . 5555 . 671–4 . 2002 . 11809971 . 10.1126/science.1065654 . 2002Sci...295..671H . 32693420 .
• Kumagai J, Hsu SY, Matsumi H, etal . INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent . J. Biol. Chem. . 277 . 35 . 31283–6 . 2002 . 12114498 . 10.1074/jbc.C200398200 . free .
• Gorlov IP, Kamat A, Bogatcheva NV, etal . Mutations of the GREAT gene cause cryptorchidism . Hum. Mol. Genet. . 11 . 19 . 2309–18 . 2003 . 12217959 . 10.1093/hmg/11.19.2309 . free .
• Sudo S, Kumagai J, Nishi S, etal . H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2 . J. Biol. Chem. . 278 . 10 . 7855–62 . 2003 . 12506116 . 10.1074/jbc.M212457200 . free .
• Ferlin A, Simonato M, Bartoloni L, etal . The INSL3-LGR8/GREAT ligand-receptor pair in human cryptorchidism . J. Clin. Endocrinol. Metab. . 88 . 9 . 4273–9 . 2003 . 12970298 . 10.1210/jc.2003-030359 . free .
• Roh J, Virtanen H, Kumagai J, etal . Lack of LGR8 gene mutation in Finnish patients with a family history of cryptorchidism . Reprod. Biomed. Online . 7 . 4 . 400–6 . 2004 . 14656401 . 10.1016/S1472-6483(10)61883-4 . free .
• Vinci G, Anjot MN, Trivin C, etal . An analysis of the genetic factors involved in testicular descent in a cohort of 14 male patients with anorchia . J. Clin. Endocrinol. Metab. . 89 . 12 . 6282–5 . 2005 . 15579790 . 10.1210/jc.2004-0891 . free .
• Büllesbach EE, Schwabe C . LGR8 signal activation by the relaxin-like factor . J. Biol. Chem. . 280 . 15 . 14586–90 . 2005 . 15708846 . 10.1074/jbc.M414443200 . free .
• Muda M, He C, Martini PG, etal . Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity . Mol. Hum. Reprod. . 11 . 8 . 591–600 . 2005 . 16051677 . 10.1093/molehr/gah205 . free .
• Rosengren KJ, Zhang S, Lin F, etal . Solution structure and characterization of the LGR8 receptor binding surface of insulin-like peptide 3 . J. Biol. Chem. . 281 . 38 . 28287–95 . 2006 . 16867980 . 10.1074/jbc.M603829200 . free .
• Bogatcheva NV, Ferlin A, Feng S, etal . T222P mutation of the insulin-like 3 hormone receptor LGR8 is associated with testicular maldescent and hinders receptor expression on the cell surface membrane . Am. J. Physiol. Endocrinol. Metab. . 292 . 1 . E138–44 . 2007 . 16926383 . 10.1152/ajpendo.00228.2006 . 17442101 .
• Scott DJ, Layfield S, Yan Y, etal . Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules . J. Biol. Chem. . 281 . 46 . 34942–54 . 2007 . 16963451 . 10.1074/jbc.M602728200 . free .
• El Houate B, Rouba H, Sibai H, etal . Novel mutations involving the INSL3 gene associated with cryptorchidism . J. Urol. . 177 . 5 . 1947–51 . 2007 . 17437853 . 10.1016/j.juro.2007.01.002 .
• Scott DJ, Wilkinson TN, Zhang S, etal . Defining the LGR8 residues involved in binding insulin-like peptide 3 . Mol. Endocrinol. . 21 . 7 . 1699–712 . 2007 . 17473281 . 10.1210/me.2007-0097 . free .

External links

• Web site: Relaxin Family Peptide Receptors: RXFP2 . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2008-12-09 . 2016-03-03 . https://web.archive.org/web/20160303193520/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3023 . dead .

Notes and References

1. Web site: Entrez Gene: RXFP2 relaxin/insulin-like family peptide receptor 2.