RU-24,969 explained

RU-24,969 is a chemical compound widely used in scientific studies. It is a selective agonist at the 5-HT1A and 5-HT1B receptors, with preference for the latter.[1] As with other 5-HT1B agonists such as CP-94,253, RU-24,969 has been found to increase the reinforcing properties of cocaine, suggesting a role for 5-HT1B receptors in cocaine addiction.[2]

See also

Notes and References

  1. Doods HN, Kalkman HO, De Jonge A, Thoolen MJ, Wilffert B, Timmermans PB, Van Zwieten PA . Differential selectivities of RU 24969 and 8-OH-DPAT for the purported 5-HT1A and 5-HT1B binding sites. Correlation between 5-HT1A affinity and hypotensive activity. . Eur J Pharmacol . 112 . 3 . 363–370 . 1985 . 3160596 . 10.1016/0014-2999(85)90782-4 .
  2. Parsons LH, Weiss F, Koob GF . Serotonin1B receptor stimulation enhances cocaine reinforcement . Journal of Neuroscience . 18 . 23 . 10078–89 . December 1998 . 9822762 . 10.1523/JNEUROSCI.18-23-10078.1998. 6793270.

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