RuvB-like 1 explained

RuvB-like 1 (E. coli), also known as RUVBL1 and TIP49, is a human gene.^[1] RUVBL1 can form a hexamer. The hexamer can form a dodecamer with RUVBL2 protein.^[2] Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity.

Interactions

RuvB-like 1 has been shown to interact with:

• ACTL6A,^[3]
• Beta-catenin,^[4]
• EP400,
• Myc,^{[3] [5]} and
• RUVBL2.^[6]

Further reading

• Doyon Y, Côté J . The highly conserved and multifunctional NuA4 HAT complex. . Curr. Opin. Genet. Dev. . 14 . 2 . 147–54 . 2004 . 15196461 . 10.1016/j.gde.2004.02.009 .
• Dawson SJ, White LA . Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. . J. Infect. . 24 . 3 . 317–20 . 1992 . 1602151 . 10.1016/S0163-4453(05)80037-4 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Kanemaki M, Makino Y, Yoshida T, Kishimoto T, Koga A, Yamamoto K, Yamamoto M, Moncollin V, Egly JM, Muramatsu M, Tamura T . Molecular cloning of a rat 49-kDa TBP-interacting protein (TIP49) that is highly homologous to the bacterial RuvB . Biochem. Biophys. Res. Commun. . 235 . 1 . 64–8 . 1997 . 9196036 . 10.1006/bbrc.1997.6729 . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Makino Y, Mimori T, Koike C, Kanemaki M, Kurokawa Y, Inoue S, Kishimoto T, Tamura T . TIP49, homologous to the bacterial DNA helicase RuvB, acts as an autoantigen in human . Biochem. Biophys. Res. Commun. . 245 . 3 . 819–23 . 1998 . 9588198 . 10.1006/bbrc.1998.8504 .
• Qiu XB, Lin YL, Thome KC, Pian P, Schlegel BP, Weremowicz S, Parvin JD, Dutta A . An eukaryotic RuvB-like protein (RUVBL1) essential for growth . J. Biol. Chem. . 273 . 43 . 27786–93 . 1998 . 9774387 . 10.1074/jbc.273.43.27786 . free .
• Holzmann K, Gerner C, Korosec T, Pöltl A, Grimm R, Sauermann G . Identification and characterization of the ubiquitously occurring nuclear matrix protein NMP 238 . Biochem. Biophys. Res. Commun. . 252 . 1 . 39–45 . 1998 . 9813143 . 10.1006/bbrc.1998.9604 .
• Bauer A, Huber O, Kemler R . Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding protein . Proc. Natl. Acad. Sci. U.S.A. . 95 . 25 . 14787–92 . 1999 . 9843967 . 24527 . 10.1073/pnas.95.25.14787 . 1998PNAS...9514787B . free .
• Kanemaki M, Kurokawa Y, Matsu-ura T, Makino Y, Masani A, Okazaki K, Morishita T, Tamura TA . TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a . J. Biol. Chem. . 274 . 32 . 22437–44 . 1999 . 10428817 . 10.1074/jbc.274.32.22437 . free .
• Salzer U, Kubicek M, Prohaska R . Isolation, molecular characterization, and tissue-specific expression of ECP-51 and ECP-54 (TIP49), two homologous, interacting erythroid cytosolic proteins . Biochim. Biophys. Acta . 1446 . 3 . 365–70 . 1999 . 10524211 . 10.1016/S0167-4781(99)00104-9 .
• Wood MA, McMahon SB, Cole MD . An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc . Mol. Cell . 5 . 2 . 321–30 . 2000 . 10882073 . 10.1016/S1097-2765(00)80427-X . free .
• Makino Y, Kanemaki M, Koga A, Osano K, Matsu-Ura T, Kurokawa Y, Kishimoto T, Tamura T . Chromosome mapping and expression of human tip49 family genes . DNA Seq. . 11 . 1–2 . 145–8 . 2000 . 10902922 . 10.3109/10425170009033982 . 24646215 .
• Ikura T, Ogryzko VV, Grigoriev M, Groisman R, Wang J, Horikoshi M, Scully R, Qin J, Nakatani Y . Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis . Cell . 102 . 4 . 463–73 . 2000 . 10966108 . 10.1016/S0092-8674(00)00051-9 . 18047169 . free .
• Hawley SB, Tamura T, Miles LA . Purification, cloning, and characterization of a profibrinolytic plasminogen-binding protein, TIP49a . J. Biol. Chem. . 276 . 1 . 179–86 . 2001 . 11027681 . 10.1074/jbc.M004919200 . free .
• Bauer A, Chauvet S, Huber O, Usseglio F, Rothbächer U, Aragnol D, Kemler R, Pradel J . Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity . EMBO J. . 19 . 22 . 6121–30 . 2001 . 11080158 . 305835 . 10.1093/emboj/19.22.6121 .
• Park J, Wood MA, Cole MD . BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation . Mol. Cell. Biol. . 22 . 5 . 1307–16 . 2002 . 11839798 . 134713 . 10.1128/MCB.22.5.1307-1316.2002 .
• Watkins NJ, Dickmanns A, Lührmann R . Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP . Mol. Cell. Biol. . 22 . 23 . 8342–52 . 2003 . 12417735 . 134055 . 10.1128/MCB.22.23.8342-8352.2002 .
• Cai Y, Jin J, Tomomori-Sato C, Sato S, Sorokina I, Parmely TJ, Conaway RC, Conaway JW . Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex . J. Biol. Chem. . 278 . 44 . 42733–6 . 2003 . 12963728 . 10.1074/jbc.C300389200 . free .

Notes and References

1. Web site: Entrez Gene: RUVBL1 RuvB-like 1 (E. coli).
2. Puri T, Wendler P, Sigala B, Saibil H, Tsaneva IR . Dodecameric structure and ATPase activity of the human TIP48/TIP49 complex . J. Mol. Biol. . 366 . 1 . 179–92 . February 2007 . 17157868 . 10.1016/j.jmb.2006.11.030 .
3. Park J, Wood MA, Cole MD . BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation . Mol. Cell. Biol. . 22 . 5 . 1307–16 . March 2002 . 11839798 . 134713 . 10.1128/mcb.22.5.1307-1316.2002.
4. Bauer A, Huber O, Kemler R . Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding protein . Proc. Natl. Acad. Sci. U.S.A. . 95 . 25 . 14787–92 . Dec 1998 . 9843967 . 24527 . 10.1073/pnas.95.25.14787. 1998PNAS...9514787B . free .
5. Fuchs M, Gerber J, Drapkin R, Sif S, Ikura T, Ogryzko V, Lane WS, Nakatani Y, Livingston DM . The p400 complex is an essential E1A transformation target . Cell . 106 . 3 . 297–307 . August 2001 . 11509179 . 10.1016/s0092-8674(01)00450-0. 15634637 . free .
6. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 2007 . 3 . 89 . 17353931 . 1847948 . 10.1038/msb4100134 .