RTN2 explained

Reticulon-2 is a protein that in humans is encoded by the RTN2 gene.^{[1] [2] [3]}

This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

Further reading

• Ballif BA . Phosphoproteomic analysis of the developing mouse brain . Mol. Cell. Proteomics . 3 . 11 . 1093–101 . 2005 . 15345747 . 10.1074/mcp.M400085-MCP200 . vanc. Villén J . Beausoleil SA . 3 . Schwartz . D . Gygi . SP . free .
• He W . Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation . Nat. Med. . 10 . 9 . 959–65 . 2004 . 15286784 . 10.1038/nm1088 . vanc. Lu Y . Qahwash I . 3 . Hu . Xiang-You . Chang . Ansi . Yan . Riqiang . 23570406 .
• Reuter TY . Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport . Exp. Cell Res. . 289 . 2 . 211–21 . 2003 . 14499622 . 10.1016/S0014-4827(03)00261-1 . vanc. Medhurst AL . Waisfisz Q . 3 . Zhi . Yu . Herterich . Sabine . Hoehn . Holger . Gross . Hans J . Joenje . Hans . Hoatlin . Maureen E .
• Oertle T, Klinger M, Stuermer CA, Schwab ME . A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family . FASEB J. . 17 . 10 . 1238–47 . 2003 . 12832288 . 10.1096/fj.02-1166hyp . free . 27903 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Geisler JG, Palmer RJ, Stubbs LJ, Mucenski ML . Nspl1, a new Z-band-associated protein . J. Muscle Res. Cell. Motil. . 20 . 7 . 661–8 . 2000 . 10672514 . 10.1023/A:1005533013926 . 26327921 .
• Roebroek AJ, Contreras B, Pauli IG, Van de Ven WJ . cDNA cloning, genomic organization, and expression of the human RTN2 gene, a member of a gene family encoding reticulons . Genomics . 51 . 1 . 98–106 . 1998 . 9693037 . 10.1006/geno.1997.5175 .

Notes and References

1. Stubbs L, Carver EA, Shannon ME, Kim J, Geisler J, Generoso EE, Stanford BG, Dunn WC, Mohrenweiser H, Zimmermann W, Watt SM, Ashworth LK . Detailed comparative map of human chromosome 19q and related regions of the mouse genome . Genomics . 35 . 3 . 499–508 . Dec 1996 . 8812484 . 10.1006/geno.1996.0390 .
2. Geisler JG, Stubbs LJ, Wasserman WW, Mucenski ML . Molecular cloning of a novel mouse gene with predominant muscle and neural expression . Mamm Genome . 9 . 4 . 274–82 . May 1998 . 9530622 . 10.1007/s003359900748 . 7091637 .
3. Web site: Entrez Gene: RTN2 reticulon 2.