RTI-353 explained

RTI(-4229)-353 is a phenyltropane derived drug which acts as an SSRI.[1] Tamagnan et al. also made some phenyltropanes with high activity and selectivity for the SERT (pM affinity).[2]

See also

Notes and References

  1. Navarro HA, Xu H, Zhong D, Blough BE, Ross WP, Kuhar MJ, Carroll FI . [(125)I]3beta-(4-ethyl-3-iodophenyl)nortropane-2beta-carboxylic acid methyl ester ([(125)I]EINT): a potent and selective radioligand for the brain serotonin transporter . Synapse . New York, N.Y. . 41 . 3 . 241–7 . September 2001 . 11418937 . 10.1002/syn.1081 . 2323766 .
  2. Tamagnan G, Alagille D, Fu X, Kula NS, Baldessarini RJ, Innis RB, Baldwin RM . Synthesis and monoamine transporter affinity of new 2beta-carbomethoxy-3beta-[aryl or heteroaryl]phenyltropanes . Bioorganic & Medicinal Chemistry Letters . 16 . 1 . 217–20 . January 2006 . 16236497 . 10.1016/j.bmcl.2005.09.016 .

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