RTI-32 explained

(–)-2β-Carbomethoxy-3β-(4-tolyl)tropane (RTI-4229-32, tolpane) is a phenyltropane-based cocaine analogue that has similar properties in vitro to related drugs such as RTI-31.[1] [2]

Compound DAT DA NET NA SERT 5HT ED50 - 23 49.8 550 37.2 178 173 0.34 - RTI-32 1.7 7.02 36 8.42 23 19.4 0.31 - 1.1 3.68 22 5.86 4.0 5.0 0.13 - 0.43 unknown 44 unknown 2.42 unknown

See also

Notes and References

  1. Remy P, Doder M, Lees A, Turjanski N, Brooks D . Depression in Parkinson's disease: loss of dopamine and noradrenaline innervation in the limbic system . Brain . 128 . Pt 6 . 1314–22 . June 2005 . 15716302 . 10.1093/brain/awh445 . free .
  2. Xu L, Izenwasser S, Katz JL, Kopajtic T, Klein-Stevens C, Zhu N, Lomenzo SA, Winfield L, Trudell ML . 6 . Synthesis and biological evaluation of 2-substituted 3beta-tolyltropane derivatives at dopamine, serotonin, and norepinephrine transporters . Journal of Medicinal Chemistry . 45 . 6 . 1203–10 . March 2002 . 11881989 . 10.1021/jm010453u .

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