RTI-120 explained

(–)-2β-Carbophenoxy-3β-(p-tolyl)tropane (RTI-4229-120) is a phenyltropane derivative which acts as a reasonably selective dopamine reuptake inhibitor, along with weaker inhibition of noradrenaline and serotonin reuptake.[1] It has a reasonably fast rate of occupancy of dopamine transporters in the brain, though slower than that of cocaine itself.[2] RTI-120 has a short duration of action, along with other p-methyl substituted phenyltropanes such as RTI-150, RTI-171 and RTI-199, giving it a more similar pharmacological profile to cocaine compared to longer acting analogues like RTI-121 and RTI-177.[3]

See also

Notes and References

  1. Silverthorn ML, Dersch CM, Baumann MH, Cadet JL, Partilla JS, Rice KC, Carroll FI, Becketts KM, Brockington A, Rothman RB . Studies of the biogenic amine transporters. V. Demonstration of two binding sites for the cocaine analog [125I]RTI-55 associated with the 5-HT transporter in rat brain membranes . The Journal of Pharmacology and Experimental Therapeutics . 273 . 1 . 213–22 . April 1995 . 7714769 .
  2. Stathis M, Scheffel U, Lever SZ, Boja JW, Carroll FI, Kuhar MJ . Rate of binding of various inhibitors at the dopamine transporter in vivo . Psychopharmacology . 119 . 4 . 376–84 . June 1995 . 7480516 . 10.1007/BF02245852.
  3. Kimmel HL, Carroll FI, Kuhar MJ . Locomotor stimulant effects of novel phenyltropanes in the mouse . Drug and Alcohol Dependence . 65 . 1 . 25–36 . December 2001 . 11714587 . 10.1016/S0376-8716(01)00144-2.

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