RSU1 explained

Ras suppressor protein 1 is a protein that in humans is encoded by the RSU1 gene.^{[1] [2]}

This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors.RSU-1 has also been seen to act as a structural protein in integrin-mediated focal-adhesion complexes. It bind strongly to the protein PINCH.

Further reading

• Cutler ML, Bassin RH, Zanoni L, Talbot N . Isolation of rsp-1, a novel cDNA capable of suppressing v-Ras transformation . Mol. Cell. Biol. . 12 . 9 . 3750–6 . 1992 . 1508180 . 10.1128/MCB.12.9.3750. 360236 .
• Tsuda T, Marinetti MR, Masuelli L, Cutler ML . The Ras suppressor RSU-1 localizes to 10p13 and its expression in the U251 glioblastoma cell line correlates with a decrease in growth rate and tumorigenic potential . Oncogene . 11 . 2 . 397–403 . 1995 . 7624154 .
• Matoba R, Okubo K, Hori N, etal . The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression . Gene . 146 . 2 . 199–207 . 1994 . 8076819 . 10.1016/0378-1119(94)90293-3 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Masuelli L, Cutler ML . Increased expression of the Ras suppressor Rsu-1 enhances Erk-2 activation and inhibits Jun kinase activation . Mol. Cell. Biol. . 16 . 10 . 5466–76 . 1996 . 8816460 . 10.1128/MCB.16.10.5466. 231547 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Chunduru S, Kawami H, Gullick R, etal . Identification of an alternatively spliced RNA for the Ras suppressor RSU-1 in human gliomas . J. Neurooncol. . 60 . 3 . 201–11 . 2003 . 12510772 . 10.1023/A:1021130620178 . 34539 .
• Gevaert K, Goethals M, Martens L, etal . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides . Nat. Biotechnol. . 21 . 5 . 566–9 . 2004 . 12665801 . 10.1038/nbt810 . 23783563 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Aboulaich N, Vainonen JP, Strålfors P, Vener AV . Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes . Biochem. J. . 383 . Pt 2 . 237–48 . 2005 . 15242332 . 10.1042/BJ20040647 . 1134064 .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Dougherty GW, Chopp T, Qi SM, Cutler ML . The Ras suppressor Rsu-1 binds to the LIM 5 domain of the adaptor protein PINCH1 and participates in adhesion-related functions . Exp. Cell Res. . 306 . 1 . 168–79 . 2005 . 15878342 . 10.1016/j.yexcr.2005.01.025 .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein–protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .

Notes and References

1. Tsuda T, Cutler ML . Human RSU1 is highly homologous to mouse Rsu-1 and localizes to human chromosome 10 . Genomics . 18 . 2 . 461–2 . Feb 1994 . 8288261 . 10.1006/geno.1993.1503 .
2. Web site: Entrez Gene: RSU1 Ras suppressor protein 1.